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    Mycs myc-like oncogene, s-myc protein [ Mus musculus (house mouse) ]

    Gene ID: 17870, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mycsprovided by MGI
    Official Full Name
    myc-like oncogene, s-myc proteinprovided by MGI
    Primary source
    MGI:MGI:1332242
    See related
    Ensembl:ENSMUSG00000044597 AllianceGenome:MGI:1332242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Predicted to be involved in negative regulation of gene expression; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Mycs in Genome Data Viewer
    Location:
    X A1.1; X 2.4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (5378958..5381319, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (5466904..5469265, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 9428 Neighboring gene STARR-seq mESC enhancer starr_46645 Neighboring gene STARR-seq mESC enhancer starr_46646 Neighboring gene predicted gene 5924 Neighboring gene STARR-seq mESC enhancer starr_46647 Neighboring gene STARR-seq mESC enhancer starr_46648 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene actin, beta pseudogene

    Genomic regions, transcripts, and products

    General gene information

    Clone Names

    • MGC151451

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010850.2NP_034980.2  protein S-Myc

      See identical proteins and their annotated locations for NP_034980.2

      Status: VALIDATED

      Source sequence(s)
      AK132789
      Consensus CDS
      CCDS29953.1
      UniProtKB/Swiss-Prot
      Q3V0Z1, Q9Z304
      Related
      ENSMUSP00000054158.4, ENSMUST00000058404.5
      Conserved Domains (2) summary
      cd00083
      Location:348405
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:10328
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      5378958..5381319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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