Lrrc7 leucine rich repeat containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc7provided by MGI
Official Full Name: leucine rich repeat containing 7provided by MGI
Primary source: MGI:MGI:2676665
See related: Ensembl:ENSMUSG00000028176 AllianceGenome:MGI:2676665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: densin; mKIAA1365; B230334C09Rik
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to postsynapse; and receptor clustering. Predicted to be located in actin cytoskeleton; dendritic spine; and filopodium. Predicted to be active in several cellular components, including axon initial segment; basolateral plasma membrane; and postsynaptic density membrane. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; cortical plate; esophagus mesenchyme; spinal cord; and trachea mesenchyme. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 5.5), cortex adult (RPKM 5.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (157772823..158268254, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (158067186..158561983, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

important role of LRRC7 in mGluR5 signaling; mutant mice had inappropriate juvenile aggressive behavior and significant anxiety-like behavior and social dysfunction in adulthood
Title: Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation.
We report that the protein densin-180 is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 L-type Ca(2+) channels in neurons. This interaction promotes coupling of Cav1.2 channels to activity-dependent gene transcription.
Title: Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Ca(v)1.2 Ca(2+) Channels at Excitatory Synapses.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
This study demonstrated that Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
Title: Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
Densin is a novel testicular protein expressed in the cell membranes of Sertoli cells.
Title: Densin is a novel cell membrane protein of Sertoli cells in the testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon initial segment	IBA Inferred from Biological aspect of Ancestor more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 7

Names: densin 180

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081358.4 → NP_001074827.1 leucine-rich repeat-containing protein 7 isoform 1

See identical proteins and their annotated locations for NP_001074827.1

Status: VALIDATED

Source sequence(s)

AC102540, AC118595, AC134449, AC145301

UniProtKB/TrEMBL

A0A0G2JFZ5, E9Q6L9

Related

ENSMUSP00000101659.2, ENSMUST00000106044.6

Conserved Domains (4) summary

cd00116
Location:166 → 406

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1452 → 1537

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:144 → 199

LRR_8; Leucine rich repeat
NM_001291452.3 → NP_001278381.1 leucine-rich repeat-containing protein 7 isoform 2

Status: VALIDATED

Source sequence(s)

AC102540, AC118595, AC134449, AC145301

Consensus CDS

CCDS80073.1

UniProtKB/Swiss-Prot

Q80TE7

UniProtKB/TrEMBL

A0A0G2JDT9

Related

ENSMUSP00000142498.2, ENSMUST00000200137.5

Conserved Domains (4) summary

cd00116
Location:166 → 406

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1405 → 1490

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:144 → 199

LRR_8; Leucine rich repeat
NM_001291453.3 → NP_001278382.1 leucine-rich repeat-containing protein 7 isoform 3

See identical proteins and their annotated locations for NP_001278382.1

Status: VALIDATED

Source sequence(s)

AC102540, AC118595, AC134449, AC145301

Consensus CDS

CCDS80072.1

UniProtKB/Swiss-Prot

Q80TE7

UniProtKB/TrEMBL

B9EHV0

Related

ENSMUSP00000142440.2, ENSMUST00000199890.5

Conserved Domains (3) summary

COG4886
Location:97 → 407

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:51 → 107

LRR_8; Leucine rich repeat
NM_001370781.1 → NP_001357710.1 leucine-rich repeat-containing protein 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC102540, AC118595, AC134449, AC145301

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1485 → 1570

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
NM_001370782.1 → NP_001357711.1 leucine-rich repeat-containing protein 7 isoform 5

Status: VALIDATED

Source sequence(s)

AC102540, AC118595, AC134449, AC145301

UniProtKB/Swiss-Prot

Q80TE7

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1438 → 1523

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

157772823..158268254 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501512.5 → XP_006501575.1 leucine-rich repeat-containing protein 7 isoform X9

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1335 → 1420

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_030252624.2 → XP_030108484.1 leucine-rich repeat-containing protein 7 isoform X15

UniProtKB/Swiss-Prot

Q80TE7

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1355 → 1440

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_006501510.5 → XP_006501573.1 leucine-rich repeat-containing protein 7 isoform X5

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1402 → 1487

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_006501508.5 → XP_006501571.1 leucine-rich repeat-containing protein 7 isoform X4

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1418 → 1503

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_017319582.3 → XP_017175071.1 leucine-rich repeat-containing protein 7 isoform X8

UniProtKB/Swiss-Prot

Q80TE7

Conserved Domains (3) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_006501511.5 → XP_006501574.1 leucine-rich repeat-containing protein 7 isoform X6

UniProtKB/Swiss-Prot

Q80TE7

UniProtKB/TrEMBL

A0A571BEA5

Related

ENSMUSP00000158628.3, ENSMUST00000238317.3

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1398 → 1483

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_036163108.1 → XP_036019001.1 leucine-rich repeat-containing protein 7 isoform X7

UniProtKB/Swiss-Prot

Q80TE7

Conserved Domains (3) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:84 → 140

LRR_8; Leucine rich repeat
XM_006501505.5 → XP_006501568.1 leucine-rich repeat-containing protein 7 isoform X2

UniProtKB/Swiss-Prot

Q80TE7

Conserved Domains (4) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1445 → 1530

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_006501507.5 → XP_006501570.1 leucine-rich repeat-containing protein 7 isoform X3

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (3) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat
XM_030252621.2 → XP_030108481.1 leucine-rich repeat-containing protein 7 isoform X10

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:97 → 407

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1302 → 1387

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:31 → 52

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:52 → 107

LRR_8; Leucine rich repeat
XM_011240122.4 → XP_011238424.1 leucine-rich repeat-containing protein 7 isoform X1

See identical proteins and their annotated locations for XP_011238424.1

UniProtKB/TrEMBL

A0A0G2JFZ5

Related

ENSMUSP00000143365.2, ENSMUST00000200196.5

Conserved Domains (4) summary

COG4886
Location:92 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1447 → 1532

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:26 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:47 → 102

LRR_8; Leucine rich repeat
XM_006501504.5 → XP_006501567.1 leucine-rich repeat-containing protein 7 isoform X1

See identical proteins and their annotated locations for XP_006501567.1

UniProtKB/TrEMBL

A0A0G2JFZ5

Conserved Domains (4) summary

COG4886
Location:92 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1447 → 1532

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:26 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:47 → 102

LRR_8; Leucine rich repeat
XM_011240123.3 → XP_011238425.1 leucine-rich repeat-containing protein 7 isoform X11

Conserved Domains (3) summary

COG4886
Location:5 → 223

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1268 → 1353

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:7 → 29

LRR_RI; leucine-rich repeat [structural motif]
XM_036163109.1 → XP_036019002.1 leucine-rich repeat-containing protein 7 isoform X13

Conserved Domains (1) summary

cd00992
Location:744 → 829

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_011240124.4 → XP_011238426.1 leucine-rich repeat-containing protein 7 isoform X12

Conserved Domains (1) summary

cd00992
Location:811 → 896

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030252622.2 → XP_030108482.1 leucine-rich repeat-containing protein 7 isoform X14

Conserved Domains (3) summary

COG4886
Location:130 → 440

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:64 → 85

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:85 → 140

LRR_8; Leucine rich repeat