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    Nkain4 Na+/K+ transporting ATPase interacting 4 [ Mus musculus (house mouse) ]

    Gene ID: 58237, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nkain4provided by MGI
    Official Full Name
    Na+/K+ transporting ATPase interacting 4provided by MGI
    Primary source
    MGI:MGI:1915372
    See related
    Ensembl:ENSMUSG00000027574 AllianceGenome:MGI:1915372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C030019F02Rik
    Summary
    Predicted to be involved in regulation of sodium ion transport. Located in membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; respiratory system; and skeleton. Orthologous to human NKAIN4 (sodium/potassium transporting ATPase interacting 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 20.5), bladder adult (RPKM 14.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkain4 in Genome Data Viewer
    Location:
    2 H4; 2 103.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180576559..180596730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180934766..180954937, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06743 Neighboring gene YTH N6-methyladenosine RNA binding protein 1 Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene STARR-seq mESC enhancer starr_06745 Neighboring gene ARF GTPase activating protein 1 Neighboring gene collagen, type XX, alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. De-Zolt S, et al. Nucleic Acids Res, 2006 Feb 13. PMID 16478711, Free PMC Article
    2. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Yang Y, et al. Hum Mol Genet, 2003 May 1. PMID 12700166
    3. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    4. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
    5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102050

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Names
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141933.1 → NP_001135405.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001135405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC061107, CK625327, EF058056
      Consensus CDS
      CCDS50841.1
      UniProtKB/Swiss-Prot
      Q9JMG4
      Related
      ENSMUSP00000104501.3, ENSMUST00000108873.9
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 177
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_021426.4 → NP_067401.3  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_067401.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      BC061107, CK625327
      Consensus CDS
      CCDS17189.1
      UniProtKB/Swiss-Prot
      A2AWN3, A6MHQ2, A6MHQ3, Q5EBQ3, Q9D1V9, Q9D8W0, Q9JMG4
      Related
      ENSMUSP00000099342.4, ENSMUST00000103053.10
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 206
      NKAIN; Na,K-Atpase Interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180576559..180596730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319153.2 → XP_017174642.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      UniProtKB/TrEMBL
      F7B7M8
      Related
      ENSMUSP00000116965.2, ENSMUST00000139929.8
      Conserved Domains (1) summary
      pfam05640
      Location:19 → 160
      NKAIN; Na,K-Atpase Interacting protein

    2. XM_030251916.2 → XP_030107776.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X6

      Conserved Domains (1) summary
      pfam05640
      Location:8 → 104
      NKAIN; Na,K-Atpase Interacting protein

    3. XM_006500690.5 → XP_006500753.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

      UniProtKB/TrEMBL
      F7B7M8
      Conserved Domains (1) summary
      pfam05640
      Location:8 → 133
      NKAIN; Na,K-Atpase Interacting protein

    4. XM_030251915.2 → XP_030107775.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X5

      UniProtKB/TrEMBL
      F7B7M8
      Conserved Domains (1) summary
      pfam05640
      Location:19 → 131
      NKAIN; Na,K-Atpase Interacting protein

    5. XM_030251914.2 → XP_030107774.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

      Conserved Domains (1) summary
      pfam05640
      Location:2 → 163
      NKAIN; Na,K-Atpase Interacting protein

    6. XM_006500689.5 → XP_006500752.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

      Conserved Domains (1) summary
      pfam05640
      Location:4 → 192
      NKAIN; Na,K-Atpase Interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMG4.1 GenPept UniProtKB/Swiss-Prot:Q9JMG4

    Gene LinkOut

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