Ssbp1 single-stranded DNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ssbp1provided by MGI
Official Full Name: single-stranded DNA binding protein 1provided by MGI
Primary source: MGI:MGI:1920040
See related: Ensembl:ENSMUSG00000029911 AllianceGenome:MGI:1920040
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MtSSB; mtDBP; 2810480P10Rik; G630031O20Rik
Summary: Predicted to enable chromatin binding activity; protein homodimerization activity; and single-stranded DNA binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in brain ventricular layer; foregut; renal cortex; and submandibular gland primordium. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human SSBP1 (single stranded DNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 17.1), CNS E14 (RPKM 12.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 18.82 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (40448302..40458757)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (40471414..40481823)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SSBP1 was down-regulated by Angiotensin II and implicated in cardiac fibrosis through fibroblast proliferation and collagen expression partly via the p53 protein.
Title: Single-Stranded DNA-Binding Protein 1 Abrogates Cardiac Fibroblast Proliferation and Collagen Expression Induced by Angiotensin II.
SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres.
Title: Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres.
plays a role in the regulation of mitochondrial morphology. (review)
Title: [Study on the novel factors regulating mitochondrial dynamics].
overexpression of Mitogenin I or mitochondrial single-stranded DNA-binding protein increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively.
Title: Regulation of mitochondrial morphology and cell survival by Mitogenin I and mitochondrial single-stranded DNA binding protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ssb (e-PCR), detects polymorphism
- UniSTS:496729

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA unwinding involved in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial genome maintenance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of helicase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: single-stranded DNA-binding protein, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286663.1 → NP_001273592.1 single-stranded DNA-binding protein, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001273592.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 2. Variants 1, 3, and 5 encode the same isoform (1) which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

BC028648, BC060290

Consensus CDS

CCDS39466.1

UniProtKB/TrEMBL

Q8R2K3

Related

ENSMUSP00000113563.2, ENSMUST00000121360.8

Conserved Domains (1) summary

TIGR00621
Location:27 → 141

ssb; single stranded DNA-binding protein (ssb)
NM_001364578.1 → NP_001351507.1 single-stranded DNA-binding protein, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

AC155653, AI509168, AK013425, BC028648

Consensus CDS

CCDS39466.1

UniProtKB/TrEMBL

Q8R2K3

Related

ENSMUSP00000114082.2, ENSMUST00000117411.8

Conserved Domains (1) summary

TIGR00621
Location:27 → 141

ssb; single stranded DNA-binding protein (ssb)
NM_028358.2 → NP_082634.1 single-stranded DNA-binding protein, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_082634.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

AK013425

Consensus CDS

CCDS20030.1

UniProtKB/Swiss-Prot

Q9CYR0

Related

ENSMUSP00000031971.7, ENSMUST00000031971.13

Conserved Domains (1) summary

cl09930
Location:27 → 134

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
NM_212468.3 → NP_997633.1 single-stranded DNA-binding protein, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_997633.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) includes an alternate 3' terminal exon, compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1) which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AK013425, BC028648

Consensus CDS

CCDS39466.1

UniProtKB/TrEMBL

Q8R2K3

Related

ENSMUSP00000110427.3, ENSMUST00000114779.9

Conserved Domains (1) summary

TIGR00621
Location:27 → 141

ssb; single stranded DNA-binding protein (ssb)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

40448302..40458757

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321664.3 → XP_017177153.1 single-stranded DNA-binding protein, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q9CYR0

Conserved Domains (1) summary

cl09930
Location:27 → 134

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
XM_006506329.3 → XP_006506392.1 single-stranded DNA-binding protein, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006506392.1

UniProtKB/Swiss-Prot

Q9CYR0

Conserved Domains (1) summary

cl09930
Location:27 → 134

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.