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    Akr7a5 aldo-keto reductase family 7, member A5 [ Mus musculus (house mouse) ]

    Gene ID: 110198, updated on 27-Dec-2024

    Summary

    Official Symbol
    Akr7a5provided by MGI
    Official Full Name
    aldo-keto reductase family 7, member A5provided by MGI
    Primary source
    MGI:MGI:107796
    See related
    Ensembl:ENSMUSG00000028743 AllianceGenome:MGI:107796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Afar; Afar1; Akr7a2; 0610025K21Rik
    Summary
    Predicted to enable aldose reductase (NADPH) activity; identical protein binding activity; and phenanthrene-9,10-epoxide hydrolase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Orthologous to several human genes including AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 97.0), kidney adult (RPKM 73.4) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Akr7a5 in Genome Data Viewer
    Location:
    4 D3; 4 70.64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139038005..139046097)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139310720..139318786)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16287 Neighboring gene STARR-seq mESC enhancer starr_11823 Neighboring gene STARR-seq mESC enhancer starr_11824 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene STARR-seq mESC enhancer starr_11826 Neighboring gene STARR-positive B cell enhancer ABC_E6244 Neighboring gene solute carrier family 66 member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138886553-138886854 Neighboring gene cyclin D3, pseudogene Neighboring gene mRNA turnover 4, ribosome maturation factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity  
    enables aldose reductase (NADPH) activity  
    enables identical protein binding  
    enables oxidoreductase activity  
    enables phenanthrene-9,10-epoxide hydrolase activity  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in mitochondrion PubMed 
    located_in nuclear envelope  

    General protein information

    Preferred Names
    aflatoxin B1 aldehyde reductase member 2
    Names
    SSA reductase
    aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
    succinic semialdehyde reductase
    NP_079613.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025337.3NP_079613.3  aflatoxin B1 aldehyde reductase member 2

      See identical proteins and their annotated locations for NP_079613.3

      Status: VALIDATED

      Source sequence(s)
      AK143203, BE652423
      Consensus CDS
      CCDS18844.1
      UniProtKB/Swiss-Prot
      A2AMV3, Q3UPU2, Q8CG76, Q8CG77, Q8JZQ8, Q9D157
      Related
      ENSMUSP00000073459.7, ENSMUST00000073787.7
      Conserved Domains (2) summary
      cd06660
      Location:46354
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      COG0667
      Location:46363
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139038005..139046097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_390721.5 RNA Sequence

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