Fam170a family with sequence similarity 170, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam170aprovided by MGI
Official Full Name: family with sequence similarity 170, member Aprovided by MGI
Primary source: MGI:MGI:2684939
See related: Ensembl:ENSMUSG00000035420 AllianceGenome:MGI:2684939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm93; Znfd
Summary: Predicted to enable DNA binding activity. Involved in positive regulation of DNA-templated transcription and transcription by RNA polymerase II. Located in nucleus. Orthologous to human FAM170A (family with sequence similarity 170 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 18.5) See more
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 27.3 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (50411436..50416087)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (50278369..50283020)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in micedagger.
Title: Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†.
Suggest that ZNFD may probably participate in the development of mouse testis and function as a transcription activator in HSE-mediated gene expression and signaling pathways.
Title: Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein FAM170A

Names: family with sequence similarity 170, member B; zinc finger domain-containing protein; zinc finger protein ZNFD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004061.2 → NP_001004061.1 protein FAM170A isoform 1

Status: VALIDATED

Source sequence(s)

AV259944, AY692449

Consensus CDS

CCDS29243.1

UniProtKB/Swiss-Prot

B2RW56, Q66LM6, Q66LM7

Related

ENSMUSP00000035910.3, ENSMUST00000039121.4
NM_001357517.1 → NP_001344446.1 protein FAM170A isoform 2

Status: VALIDATED

Source sequence(s)

AV259944, AY692449, BC172108

Consensus CDS

CCDS89240.1

UniProtKB/TrEMBL

A0A494BAQ9

Related

ENSMUSP00000158194.2, ENSMUST00000238078.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

50411436..50416087

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525869.1 → XP_006525932.1 protein FAM170A isoform X1

Conserved Domains (1) summary

pfam17734
Location:148 → 265

Spt46; Spermatogenesis-associated protein 46
XM_006525870.1 → XP_006525933.1 protein FAM170A isoform X2

Conserved Domains (1) summary

pfam17734
Location:146 → 263

Spt46; Spermatogenesis-associated protein 46
XM_030250438.1 → XP_030106298.1 protein FAM170A isoform X3

Conserved Domains (1) summary

pfam17734
Location:146 → 263

Spt46; Spermatogenesis-associated protein 46
XM_017317888.1 → XP_017173377.1 protein FAM170A isoform X4

Conserved Domains (1) summary

pfam17734
Location:34 → 151

Spt46; Spermatogenesis-associated protein 46