Cit citron [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Citprovided by MGI
Official Full Name: citronprovided by MGI
Primary source: MGI:MGI:105313
See related: Ensembl:ENSMUSG00000029516 AllianceGenome:MGI:105313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRIK; Cit-k; CRIK-SK; C030025P15Rik
Summary: Enables protein serine/threonine kinase activity. Involved in generation of neurons and mitotic cell cycle. Acts upstream of or within several processes, including dendrite development; metaphase/anaphase transition of mitotic cell cycle; and negative regulation of dendrite morphogenesis. Located in actin cytoskeleton; ruffle; and vacuole. Is expressed in several structures, including central nervous system; hemolymphoid system gland; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 9.3), frontal lobe adult (RPKM 8.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115983284..116147012)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115845224..116008953)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.
Title: Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.
Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.
Title: Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
p27 has a role in cytokinesis via the regulation of citron-K activity
Title: p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
CITRON has a role in proliferation of hepatocellular carcinoma cells
Title: RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.
Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
Title: Discs large 5 is required for polarization of citron kinase in mitotic neural precursors.
Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.
Title: Deletion of the citron kinase gene selectively affects the number and distribution of interneurons in barrelfield cortex.
These results suggest that the TTC3-RhoA-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
Title: The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase and functions in the control of G(2)/M transition in the hepatocyte cell cycle
Title: Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes.
Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.
Title: Role of citron kinase in dendritic morphogenesis of cortical neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit187 (e-PCR), detects polymorphism
- UniSTS:130318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in generation of neurons	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of dendrite morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: citron Rho-interacting kinase

Names: citron kinase; citron-N; rho-interacting, serine/threonine-protein kinase 21

NP_031734.3

EC 2.7.11.1

XP_006530193.1

EC 2.7.11.1

XP_006530194.1

EC 2.7.11.1

XP_006530195.1

EC 2.7.11.1

XP_006530196.1

EC 2.7.11.1

XP_006530197.1

EC 2.7.11.1

XP_006530198.1

EC 2.7.11.1

XP_006530199.1

EC 2.7.11.1

XP_006530200.1

EC 2.7.11.1

XP_006530201.1

EC 2.7.11.1

XP_006530202.1

EC 2.7.11.1

XP_006530203.1

EC 2.7.11.1

XP_006530204.1

EC 2.7.11.1

XP_006530205.1

EC 2.7.11.1

XP_006530206.1

EC 2.7.11.1

XP_006530208.1

EC 2.7.11.1

XP_006530209.1

EC 2.7.11.1

XP_006530210.1

EC 2.7.11.1

XP_006530212.1

EC 2.7.11.1

XP_006530213.1

EC 2.7.11.1

XP_006530214.1

EC 2.7.11.1

XP_006530215.1

EC 2.7.11.1

XP_006530216.1

EC 2.7.11.1

XP_011246465.1

EC 2.7.11.1

XP_017176130.1

EC 2.7.11.1

XP_017176132.1

EC 2.7.11.1

XP_017176133.1

EC 2.7.11.1

XP_017176134.1

EC 2.7.11.1

XP_017176135.1

EC 2.7.11.1

XP_030109958.1

EC 2.7.11.1

XP_030109959.1

EC 2.7.11.1

XP_030109960.1

EC 2.7.11.1

XP_036020657.1

EC 2.7.11.1

XP_036020658.1

EC 2.7.11.1

XP_036020659.1

EC 2.7.11.1

XP_036020660.1

EC 2.7.11.1

XP_036020661.1

EC 2.7.11.1

XP_036020662.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007708.3 → NP_031734.3 citron Rho-interacting kinase

See identical proteins and their annotated locations for NP_031734.3

Status: VALIDATED

Source sequence(s)

AC115795, AC162461

Consensus CDS

CCDS19597.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

UniProtKB/TrEMBL

E9QL53

Related

ENSMUSP00000062049.9, ENSMUST00000051704.15

Conserved Domains (5) summary

smart00036
Location:1619 → 1915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1470 → 1589

PH; Pleckstrin homology domain

COG1196
Location:473 → 1319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1389 → 1437

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115983284..116147012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530131.3 → XP_006530194.1 citron Rho-interacting kinase isoform X1

See identical proteins and their annotated locations for XP_006530194.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_030254099.2 → XP_030109959.1 citron Rho-interacting kinase isoform X8

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1658 → 1954

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1494 → 1613

PH; Pleckstrin homology domain

COG1196
Location:473 → 1343

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1413 → 1461

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530146.4 → XP_006530209.1 citron Rho-interacting kinase isoform X17

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

cl02434
Location:1687 → 1743

CNH; CNH domain
XM_036164765.1 → XP_036020658.1 citron Rho-interacting kinase isoform X18

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

COG1196
Location:473 → 1357

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1508 → 1627

PH; PH domain

cd20814
Location:1423 → 1478

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

cl02434
Location:1672 → 1728

CNH; CNH domain
XM_006530130.5 → XP_006530193.1 citron Rho-interacting kinase isoform X1

See identical proteins and their annotated locations for XP_006530193.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530134.5 → XP_006530197.1 citron Rho-interacting kinase isoform X2

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530137.5 → XP_006530200.1 citron Rho-interacting kinase isoform X5

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1672 → 1968

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_036164764.1 → XP_036020657.1 citron Rho-interacting kinase isoform X6

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1672 → 1968

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1523 → 1642

PH; PH domain

cd20814
Location:1438 → 1493

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006530136.5 → XP_006530199.1 citron Rho-interacting kinase isoform X4

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1672 → 1968

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1508 → 1627

PH; Pleckstrin homology domain

COG1196
Location:473 → 1357

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1427 → 1475

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_030254100.2 → XP_030109960.1 citron Rho-interacting kinase isoform X9

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1657 → 1953

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1508 → 1627

PH; Pleckstrin homology domain

COG1196
Location:473 → 1357

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1427 → 1475

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530135.5 → XP_006530198.1 citron Rho-interacting kinase isoform X3

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1678 → 1974

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1514 → 1633

PH; Pleckstrin homology domain

COG1196
Location:473 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1433 → 1481

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_030254098.1 → XP_030109958.1 citron Rho-interacting kinase isoform X7

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1663 → 1959

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1499 → 1618

PH; Pleckstrin homology domain

COG1196
Location:473 → 1348

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1418 → 1466

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530139.5 → XP_006530202.1 citron Rho-interacting kinase isoform X10

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1645 → 1941

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1481 → 1600

PH; Pleckstrin homology domain

COG1196
Location:555 → 1330

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1400 → 1448

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530138.5 → XP_006530201.1 citron Rho-interacting kinase isoform X8

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1658 → 1954

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1494 → 1613

PH; Pleckstrin homology domain

COG1196
Location:473 → 1343

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1413 → 1461

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530140.4 → XP_006530203.1 citron Rho-interacting kinase isoform X11

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

UniProtKB/TrEMBL

D3YU89

Related

ENSMUSP00000099620.4, ENSMUST00000102560.7

Conserved Domains (5) summary

smart00036
Location:1634 → 1930

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1485 → 1604

PH; Pleckstrin homology domain

COG1196
Location:473 → 1334

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1404 → 1452

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530141.4 → XP_006530204.1 citron Rho-interacting kinase isoform X12

See identical proteins and their annotated locations for XP_006530204.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

UniProtKB/TrEMBL

E9QL53

Conserved Domains (5) summary

smart00036
Location:1619 → 1915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1470 → 1589

PH; Pleckstrin homology domain

COG1196
Location:473 → 1319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1389 → 1437

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530143.4 → XP_006530206.1 citron Rho-interacting kinase isoform X14

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

UniProtKB/TrEMBL

D3Z1U0

Related

ENSMUSP00000107639.3, ENSMUST00000112008.9

Conserved Domains (5) summary

smart00036
Location:1592 → 1888

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1443 → 1562

PH; Pleckstrin homology domain

COG1196
Location:455 → 1292

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1362 → 1410

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530145.4 → XP_006530208.1 citron Rho-interacting kinase isoform X15

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

UniProtKB/TrEMBL

F6SBR5

Related

ENSMUSP00000115802.3, ENSMUST00000141101.5

Conserved Domains (5) summary

smart00036
Location:1577 → 1873

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1428 → 1547

PH; Pleckstrin homology domain

COG1196
Location:480 → 1282

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1347 → 1395

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_011248163.3 → XP_011246465.1 citron Rho-interacting kinase isoform X16

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1577 → 1873

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1428 → 1547

PH; Pleckstrin homology domain

COG1196
Location:480 → 1282

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1347 → 1395

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530142.4 → XP_006530205.1 citron Rho-interacting kinase isoform X13

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530133.4 → XP_006530196.1 citron Rho-interacting kinase isoform X1

See identical proteins and their annotated locations for XP_006530196.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_036164766.1 → XP_036020659.1 citron Rho-interacting kinase isoform X19

Conserved Domains (5) summary

PTZ00449
Location:1554 → 1645

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1242 → 1538

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:28 → 927

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1078 → 1197

PH; PH domain

cd20814
Location:993 → 1048

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006530132.5 → XP_006530195.1 citron Rho-interacting kinase isoform X1

See identical proteins and their annotated locations for XP_006530195.1

UniProtKB/Swiss-Prot

O88528, O88937, O88938, P49025, Q3UM99, Q8CIJ1

Conserved Domains (5) summary

smart00036
Location:1687 → 1983

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1523 → 1642

PH; Pleckstrin homology domain

COG1196
Location:473 → 1372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:1442 → 1490

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
XM_006530150.5 → XP_006530213.1 citron Rho-interacting kinase isoform X22

Conserved Domains (5) summary

PTZ00449
Location:1533 → 1624

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1221 → 1517

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1057 → 1176

PH; Pleckstrin homology domain

COG1196
Location:7 → 906

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:976 → 1024

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036164768.1 → XP_036020661.1 citron Rho-interacting kinase isoform X24

Conserved Domains (5) summary

PTZ00449
Location:1504 → 1595

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1192 → 1488

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:7 → 877

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1028 → 1147

PH; PH domain

cd20814
Location:943 → 998

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006530149.5 → XP_006530212.1 citron Rho-interacting kinase isoform X21

Conserved Domains (5) summary

PTZ00449
Location:1541 → 1632

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1229 → 1525

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1065 → 1184

PH; Pleckstrin homology domain

COG1196
Location:15 → 914

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:984 → 1032

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017320644.3 → XP_017176133.1 citron Rho-interacting kinase isoform X26

Conserved Domains (5) summary

PTZ00449
Location:1499 → 1590

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1187 → 1483

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1023 → 1142

PH; Pleckstrin homology domain

COG1196
Location:97 → 872

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:942 → 990

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017320645.3 → XP_017176134.1 citron Rho-interacting kinase isoform X27

Conserved Domains (5) summary

PTZ00449
Location:1490 → 1581

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1178 → 1474

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1014 → 1133

PH; Pleckstrin homology domain

COG1196
Location:5 → 863

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:933 → 981

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017320641.3 → XP_017176130.1 citron Rho-interacting kinase isoform X23

Conserved Domains (5) summary

PTZ00449
Location:1512 → 1603

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1200 → 1496

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1036 → 1155

PH; Pleckstrin homology domain

COG1196
Location:15 → 885

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:955 → 1003

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036164769.1 → XP_036020662.1 citron Rho-interacting kinase isoform X29

Conserved Domains (5) summary

PTZ00449
Location:1482 → 1573

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1170 → 1466

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:15 → 870

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1021 → 1140

PH; PH domain

cd20814
Location:936 → 991

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_017320643.3 → XP_017176132.1 citron Rho-interacting kinase isoform X25

Conserved Domains (5) summary

PTZ00449
Location:1503 → 1594

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1191 → 1487

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1027 → 1146

PH; Pleckstrin homology domain

COG1196
Location:15 → 876

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:946 → 994

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_017320646.3 → XP_017176135.1 citron Rho-interacting kinase isoform X28

Conserved Domains (5) summary

PTZ00449
Location:1488 → 1579

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1176 → 1472

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1012 → 1131

PH; Pleckstrin homology domain

COG1196
Location:15 → 861

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:931 → 979

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006530151.5 → XP_006530214.1 citron Rho-interacting kinase isoform X30

See identical proteins and their annotated locations for XP_006530214.1

UniProtKB/Swiss-Prot

P49025

Conserved Domains (5) summary

PTZ00449
Location:1473 → 1564

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1161 → 1457

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:1012 → 1131

PH; Pleckstrin homology domain

COG1196
Location:15 → 861

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:931 → 979

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006530147.2 → XP_006530210.1 citron Rho-interacting kinase isoform X19

See identical proteins and their annotated locations for XP_006530210.1

Conserved Domains (5) summary

PTZ00449
Location:1554 → 1645

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1242 → 1538

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:28 → 927

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1078 → 1197

PH; PH domain

cd20814
Location:993 → 1048

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_036164767.1 → XP_036020660.1 citron Rho-interacting kinase isoform X20

Conserved Domains (5) summary

PTZ00449
Location:1545 → 1636

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1233 → 1529

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:28 → 918

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1069 → 1188

PH; PH domain

cd20814
Location:984 → 1039

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006530152.2 → XP_006530215.1 citron Rho-interacting kinase isoform X31

Conserved Domains (5) summary

PTZ00449
Location:1185 → 1276

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:873 → 1169

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:709 → 828

PH; Pleckstrin homology domain

COG1196
Location:2 → 580

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:628 → 676

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006530153.1 → XP_006530216.1 citron Rho-interacting kinase isoform X32

Related

ENSMUST00000122877.8

Conserved Domains (4) summary

smart00036
Location:849 → 1145

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00233
Location:700 → 819

PH; Pleckstrin homology domain

COG1196
Location:2 → 571

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00029
Location:619 → 667

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...