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    Fggy FGGY carbohydrate kinase domain containing [ Mus musculus (house mouse) ]

    Gene ID: 75578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fggyprovided by MGI
    Official Full Name
    FGGY carbohydrate kinase domain containingprovided by MGI
    Primary source
    MGI:MGI:1922828
    See related
    Ensembl:ENSMUSG00000028573 AllianceGenome:MGI:1922828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310009E04Rik
    Summary
    Predicted to enable D-ribulokinase activity. Predicted to be involved in carbohydrate phosphorylation; neuron cellular homeostasis; and pentose metabolic process. Predicted to be active in cytoplasm. Is expressed in liver lobe; metanephros; and olfactory epithelium. Orthologous to human FGGY (FGGY carbohydrate kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 11.8), liver adult (RPKM 8.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fggy in Genome Data Viewer
    Location:
    4 C5; 4 43.83 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95445717..95815176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (95557480..95926939)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene predicted gene, 25004 Neighboring gene predicted gene, 40206 Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene hook microtubule tethering protein 1 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling. Smith AL, et al. Gene, 2021 Oct 20. PMID 34280510
    2. Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice. Taylor JA, et al. Endocrinology, 2018 Feb 1. PMID 29220483, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
      Title: FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
    2. The strength of Fggy mRNA expression significantly correlated with increased whole body weight and gonadal fat weight of males but not females.
      Title: Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118640, RP23-472I13.1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-ribulokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FGGY carbohydrate kinase domain-containing protein
    Names
    D-ribulokinase FGGY
    NP_001106883.1
    NP_083623.1
    XP_006503524.1
    XP_006503531.1
    XP_006503535.1
    XP_006503537.1
    XP_006503539.1
    XP_011238935.1
    XP_011238937.1
    XP_011238938.1
    XP_011238939.1
    XP_011238941.1
    XP_011238945.1
    XP_011238946.1
    XP_011238947.1
    XP_017175919.1
    XP_017175920.1
    XP_030109730.1
    XP_030109731.1
    XP_030109732.1
    XP_030109733.1
    XP_030109734.1
    XP_036020408.1
    XP_036020409.1
    XP_036020410.1
    XP_036020411.1
    XP_036020412.1
    XP_036020413.1
    XP_036020414.1
    XP_036020415.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113412.1 → NP_001106883.1  FGGY carbohydrate kinase domain-containing protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK009249, AK138439, BX519665, BY073369
      Consensus CDS
      CCDS51233.1
      UniProtKB/Swiss-Prot
      A2AJL3, Q8BUF2, Q8K0F0, Q9D7H0
      UniProtKB/TrEMBL
      A0A8X8M4B3
      Related
      ENSMUSP00000078216.5, ENSMUST00000079223.11
      Conserved Domains (1) summary
      cd07782
      Location:11 → 545
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    2. NM_029347.2 → NP_083623.1  FGGY carbohydrate kinase domain-containing protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' and 3' exon structure compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK085534, AL772131, AL844609, BX005293, BY755248, CB953569
      Consensus CDS
      CCDS18365.1
      UniProtKB/TrEMBL
      A0A8X8RHI6
      Related
      ENSMUSP00000043460.5, ENSMUST00000043335.11
      Conserved Domains (1) summary
      cd07782
      Location:11 → 364
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      95445717..95815176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320430.3 → XP_017175919.1  FGGY carbohydrate kinase domain-containing protein isoform X8

      Conserved Domains (1) summary
      cd07782
      Location:11 → 433
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    2. XM_030253871.2 → XP_030109731.1  FGGY carbohydrate kinase domain-containing protein isoform X11

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:11 → 509
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    3. XM_017320431.1 → XP_017175920.1  FGGY carbohydrate kinase domain-containing protein isoform X20

      Conserved Domains (1) summary
      cd07782
      Location:19 → 406
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    4. XM_006503472.5 → XP_006503535.1  FGGY carbohydrate kinase domain-containing protein isoform X18

      Related
      ENSMUST00000176162.8
      Conserved Domains (1) summary
      cd07782
      Location:11 → 434
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    5. XM_030253872.2 → XP_030109732.1  FGGY carbohydrate kinase domain-containing protein isoform X24

      UniProtKB/TrEMBL
      A0A8X8RHI6
      Conserved Domains (1) summary
      cd07782
      Location:11 → 364
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    6. XM_036164521.1 → XP_036020414.1  FGGY carbohydrate kinase domain-containing protein isoform X22

      Conserved Domains (1) summary
      cd07782
      Location:19 → 420
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    7. XM_030253874.1 → XP_030109734.1  FGGY carbohydrate kinase domain-containing protein isoform X25

      Conserved Domains (1) summary
      cl17037
      Location:2 → 336
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    8. XM_006503474.2 → XP_006503537.1  FGGY carbohydrate kinase domain-containing protein isoform X21

      UniProtKB/TrEMBL
      A2AJL4
      Conserved Domains (1) summary
      cd07782
      Location:1 → 432
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    9. XM_011240644.1 → XP_011238946.1  FGGY carbohydrate kinase domain-containing protein isoform X17

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    10. XM_011240637.2 → XP_011238939.1  FGGY carbohydrate kinase domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 517
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    11. XM_011240645.1 → XP_011238947.1  FGGY carbohydrate kinase domain-containing protein isoform X19

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 447
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    12. XM_036164515.1 → XP_036020408.1  FGGY carbohydrate kinase domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 516
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    13. XM_036164518.1 → XP_036020411.1  FGGY carbohydrate kinase domain-containing protein isoform X12

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    14. XM_011240636.2 → XP_011238938.1  FGGY carbohydrate kinase domain-containing protein isoform X4

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 515
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    15. XM_036164516.1 → XP_036020409.1  FGGY carbohydrate kinase domain-containing protein isoform X6

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    16. XM_036164517.1 → XP_036020410.1  FGGY carbohydrate kinase domain-containing protein isoform X10

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 513
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    17. XM_036164519.1 → XP_036020412.1  FGGY carbohydrate kinase domain-containing protein isoform X13

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    18. XM_011240635.1 → XP_011238937.1  FGGY carbohydrate kinase domain-containing protein isoform X5

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 513
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    19. XM_006503468.4 → XP_006503531.1  FGGY carbohydrate kinase domain-containing protein isoform X14

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    20. XM_036164520.1 → XP_036020413.1  FGGY carbohydrate kinase domain-containing protein isoform X16

      Conserved Domains (1) summary
      cd07782
      Location:19 → 441
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    21. XM_011240639.4 → XP_011238941.1  FGGY carbohydrate kinase domain-containing protein isoform X9

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 514
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    22. XM_011240643.2 → XP_011238945.1  FGGY carbohydrate kinase domain-containing protein isoform X15

      Conserved Domains (1) summary
      cd07782
      Location:19 → 442
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    23. XM_036164522.1 → XP_036020415.1  FGGY carbohydrate kinase domain-containing protein isoform X23

      UniProtKB/TrEMBL
      A0A8X8RHI6
      Conserved Domains (1) summary
      cd07782
      Location:19 → 372
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    24. XM_011240633.2 → XP_011238935.1  FGGY carbohydrate kinase domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:19 → 553
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    25. XM_006503461.4 → XP_006503524.1  FGGY carbohydrate kinase domain-containing protein isoform X2

      UniProtKB/Swiss-Prot
      A2AJL3, Q8BUF2, Q8K0F0, Q9D7H0
      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:11 → 545
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    26. XM_030253873.2 → XP_030109733.1  FGGY carbohydrate kinase domain-containing protein isoform X25

      Conserved Domains (1) summary
      cl17037
      Location:2 → 336
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    27. XM_030253870.2 → XP_030109730.1  FGGY carbohydrate kinase domain-containing protein isoform X11

      UniProtKB/TrEMBL
      A0A8X8M4B3
      Conserved Domains (1) summary
      cd07782
      Location:11 → 509
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases

    28. XM_006503476.1 → XP_006503539.1  FGGY carbohydrate kinase domain-containing protein isoform X26

      UniProtKB/Swiss-Prot
      A2AJL3
      Conserved Domains (1) summary
      cl17037
      Location:1 → 245
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJL3.1 GenPept UniProtKB/Swiss-Prot:A2AJL3

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