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    Glra4 glycine receptor, alpha 4 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14657, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glra4provided by MGI
    Official Full Name
    glycine receptor, alpha 4 subunitprovided by MGI
    Primary source
    MGI:MGI:95750
    See related
    Ensembl:ENSMUSG00000018595 AllianceGenome:MGI:95750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables extracellularly glycine-gated chloride channel activity. Involved in chloride transmembrane transport and response to amino acid. Located in plasma membrane. Is active in glycinergic synapse and postsynaptic specialization membrane. Is expressed in brain. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Glra4 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135655107..135680935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136754515..136780141, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene mortality factor 4 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1 Neighboring gene RAB9B, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Clone Names

    • MGC130223, MGC130237

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of chloride channel complex  
    located_in dendrite  
    is_active_in glycinergic synapse PubMed 
    located_in perikaryon  
    located_in plasma membrane PubMed 
    is_active_in postsynaptic specialization membrane PubMed 

    General protein information

    Preferred Names
    glycine receptor subunit alpha-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425633.1NP_001412562.1  glycine receptor subunit alpha-4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887
    2. NM_001425634.1NP_001412563.1  glycine receptor subunit alpha-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887
    3. NM_001425635.1NP_001412564.1  glycine receptor subunit alpha-4 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887
    4. NM_001425636.1NP_001412565.1  glycine receptor subunit alpha-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671887
      UniProtKB/TrEMBL
      Q2TB05
    5. NM_010297.3NP_034427.2  glycine receptor subunit alpha-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034427.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL671887
      Consensus CDS
      CCDS53195.1
      UniProtKB/Swiss-Prot
      A2AEA9, Q45V76, Q61603, Q8VHF3
      UniProtKB/TrEMBL
      Q2TB05
      Related
      ENSMUSP00000018739.5, ENSMUST00000018739.5
      Conserved Domains (1) summary
      TIGR00860
      Location:9444
      LIC; Cation transporter family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135655107..135680935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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