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    Zscan2 zinc finger and SCAN domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 22691, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zscan2provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 2provided by MGI
    Primary source
    MGI:MGI:99176
    See related
    Ensembl:ENSMUSG00000038797 AllianceGenome:MGI:99176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp29; Zfp-29
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ZSCAN2 (zinc finger and SCAN domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 7.0), CNS E14 (RPKM 4.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan2 in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80510485..80539740)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80860737..80878675)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87792406-87792515 Neighboring gene predicted gene 15880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87812125-87812234 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model. Sánchez Carretero L, et al. PLoS One, 2024. PMID 39172905, Free PMC Article
    2. A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions†. Lord T, et al. Biol Reprod, 2022 Jun 13. PMID 35244684, Free PMC Article
    3. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis. Denny P, et al. Gene, 1991 Oct 15. PMID 1937051
    4. Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7. Denny P, et al. Mamm Genome, 1995 Sep. PMID 8535085
    5. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
      Title: Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 2
    Names
    zinc finger protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382511.1 → NP_001369440.1  zinc finger and SCAN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109257
      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    2. NM_001382512.1 → NP_001369441.1  zinc finger and SCAN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109257
      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    3. NM_001382513.1 → NP_001369442.1  zinc finger and SCAN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109257
      Conserved Domains (3) summary
      COG5048
      Location:219 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:363 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    4. NM_001382514.1 → NP_001369443.1  zinc finger and SCAN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109257
      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    5. NM_001382515.1 → NP_001369444.1  zinc finger and SCAN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109257
      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    6. NM_009553.2 → NP_033579.1  zinc finger and SCAN domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_033579.1

      Status: VALIDATED

      Source sequence(s)
      BC046961
      Consensus CDS
      CCDS21399.1
      UniProtKB/Swiss-Prot
      Q07230
      Related
      ENSMUSP00000042321.8, ENSMUST00000044115.9
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80510485..80539740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540811.4 → XP_006540874.1  zinc finger and SCAN domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006540874.1

      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    2. XM_006540808.5 → XP_006540871.1  zinc finger and SCAN domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006540871.1

      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    3. XM_006540812.5 → XP_006540875.1  zinc finger and SCAN domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006540875.1

      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain

    4. XM_006540810.5 → XP_006540873.1  zinc finger and SCAN domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006540873.1

      UniProtKB/Swiss-Prot
      Q07230
      Conserved Domains (3) summary
      COG5048
      Location:220 → 600
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:69 → 131
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07230.1 GenPept UniProtKB/Swiss-Prot:Q07230

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