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    Dtwd2 DTW domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 68857, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dtwd2provided by MGI
    Official Full Name
    DTW domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916107
    See related
    Ensembl:ENSMUSG00000024505 AllianceGenome:MGI:1916107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190002H09Rik; 8030470C17Rik
    Summary
    Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in RNA glycosylation and tRNA modification. Predicted to be located in cytoplasm and nucleus. Orthologous to human DTWD2 (DTW domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 1.3), adrenal adult (RPKM 0.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtwd2 in Genome Data Viewer
    Location:
    18 D1; 18 27.09 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (49829212..49890255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (49696145..49755651, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700044K03 gene Neighboring gene STARR-seq mESC enhancer starr_44563 Neighboring gene predicted gene, 32958 Neighboring gene STARR-positive B cell enhancer ABC_E4247 Neighboring gene STARR-seq mESC enhancer starr_44569 Neighboring gene predicted gene 16283 Neighboring gene STARR-positive B cell enhancer mm9_chr18:49936442-49936743 Neighboring gene STARR-positive B cell enhancer ABC_E1956 Neighboring gene RIKEN cDNA 1700065O20 gene Neighboring gene predicted gene, 57648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA-uridine aminocarboxypropyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-uridine aminocarboxypropyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-uridine aminocarboxypropyltransferase 2
    Names
    DTW domain-containing protein 2
    NP_001164431.1
    NP_081130.1
    XP_006526275.1
    XP_006526276.1
    XP_006526277.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170960.1 → NP_001164431.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001164431.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC112984, AK004450, AK033232, AK144689, BB868459
      Consensus CDS
      CCDS50286.1
      UniProtKB/TrEMBL
      B7ZP35
      Related
      ENSMUSP00000025383.10, ENSMUST00000025383.10
      Conserved Domains (1) summary
      cl01221
      Location:66 → 160
      DTW; DTW domain

    2. NM_026854.3 → NP_081130.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_081130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC112984, AK004450, AK033232, AK144689, BB868459
      Consensus CDS
      CCDS37815.1
      UniProtKB/Swiss-Prot
      Q9D0U1
      UniProtKB/TrEMBL
      B2RTH8
      Related
      ENSMUSP00000128219.3, ENSMUST00000163590.9
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 256
      DTW; DTW domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      49829212..49890255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526214.4 → XP_006526277.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X3

      Conserved Domains (1) summary
      cl01221
      Location:362 → 414
      DTW; DTW domain

    2. XM_006526212.4 → XP_006526275.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam03942
      Location:331 → 510
      DTW; DTW domain

    3. XM_006526213.5 → XP_006526276.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X2

      Conserved Domains (1) summary
      pfam03942
      Location:254 → 433
      DTW; DTW domain

    RNA

    1. XR_386011.4 RNA Sequence

    2. XR_003952540.2 RNA Sequence

    3. XR_386012.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0U1.1 GenPept UniProtKB/Swiss-Prot:Q9D0U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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