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    Hnrnpl heterogeneous nuclear ribonucleoprotein L [ Mus musculus (house mouse) ]

    Gene ID: 15388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnplprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Lprovided by MGI
    Primary source
    MGI:MGI:104816
    See related
    Ensembl:ENSMUSG00000015165 AllianceGenome:MGI:104816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpl; D830027H13Rik
    Summary
    Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is active in synapse. Is expressed in several structures, including brain; early conceptus; female reproductive system; sensory organ; and tail unsegmented mesenchyme. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 136.9), limb E14.5 (RPKM 90.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnpl in Genome Data Viewer
    Location:
    7 B1; 7 16.93 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28507971..28521693)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28808546..28822268)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene Ras and Rab interactor-like Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene enoyl coenzyme A hydratase 1, peroxisomal Neighboring gene lectin, galactose binding, soluble 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Peddigari S, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23161687, Free PMC Article
    2. Identification of a regulatory cis-element within the 3'-untranslated region of the murine inducible nitric oxide synthase (iNOS) mRNA; interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression. Söderberg M, et al. Mol Immunol, 2007 Jan. PMID 16584775
    3. A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting. Ruan X, et al. Cell Rep, 2016 Mar 1. PMID 26904944, Free PMC Article
    4. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells. Li M, et al. Cell Stem Cell, 2015 Jun 4. PMID 25936916, Free PMC Article
    5. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Li Y, et al. Adv Sci (Weinh), 2021 Jul. PMID 34258149, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation.
      Title: Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation.
    2. hnRNPL expression dynamics in the embryo and placenta.
      Title: hnRNPL expression dynamics in the embryo and placenta.
    3. Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
      Title: Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
    4. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
      Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
    5. Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
      Title: Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
    6. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
      Title: HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.
    7. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
      Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    8. data suggest that hnRNP L is critical for the survival and functional integrity of HSCs by restricting the activation of caspase-dependent death receptor pathways
      Title: Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.
    9. lncLGR facilitates the recruitment of hnRNPL to the GCK promoter and suppresses GCK transcription.
      Title: A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting.
    10. Hnrnpl binds to p53 and inhibits its activation in mouse embryonic stem cells.
      Title: An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA intronic binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein L
    Names
    hnRNP L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402935.1 → NP_001389864.1  heterogeneous nuclear ribonucleoprotein L isoform a

      Status: VALIDATED

      Source sequence(s)
      AC171210
      UniProtKB/TrEMBL
      Q3UMT7
      Related
      ENSMUSP00000134734.2, ENSMUST00000174477.8

    2. NM_001402936.1 → NP_001389865.1  heterogeneous nuclear ribonucleoprotein L isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171210
      UniProtKB/TrEMBL
      Q3UMT7
      Conserved Domains (1) summary
      TIGR01649
      Location:1 → 491
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    3. NM_001402937.1 → NP_001389866.1  heterogeneous nuclear ribonucleoprotein L isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171210
      UniProtKB/TrEMBL
      Q3UMT7
      Conserved Domains (1) summary
      TIGR01649
      Location:1 → 491
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    4. NM_001402938.1 → NP_001389867.1  heterogeneous nuclear ribonucleoprotein L isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171210
      UniProtKB/TrEMBL
      G3UY38
      Related
      ENSMUSP00000133932.2, ENSMUST00000172529.8

    5. NM_001402939.1 → NP_001389868.1  heterogeneous nuclear ribonucleoprotein L isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171210
      UniProtKB/TrEMBL
      G3UY38

    6. NM_177301.6 → NP_796275.3  heterogeneous nuclear ribonucleoprotein L isoform b

      See identical proteins and their annotated locations for NP_796275.3

      Status: VALIDATED

      Source sequence(s)
      AC171210
      Consensus CDS
      CCDS39864.2
      UniProtKB/Swiss-Prot
      O54789, Q499X2, Q8K0S7, Q8R081
      UniProtKB/TrEMBL
      Q3UMT7
      Related
      ENSMUSP00000133728.2, ENSMUST00000174548.8
      Conserved Domains (1) summary
      TIGR01649
      Location:97 → 584
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. NR_175319.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171210

    2. NR_175320.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171210
      Related
      ENSMUST00000174882.8

    3. NR_175321.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171210

    4. NR_175322.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171210

    5. NR_175323.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171210

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28507971..28521693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539560.2 → XP_006539623.1  heterogeneous nuclear ribonucleoprotein L isoform X5

      Conserved Domains (1) summary
      TIGR01649
      Location:97 → 291
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    2. XM_036152696.1 → XP_036008589.1  heterogeneous nuclear ribonucleoprotein L isoform X6

      Conserved Domains (1) summary
      TIGR01649
      Location:97 → 292
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. XR_003946390.1 RNA Sequence

    2. XR_004934017.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R081.2 GenPept UniProtKB/Swiss-Prot:Q8R081

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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