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    Slfn10 schlafen 10 [ Mus musculus (house mouse) ]

    Gene ID: 237887, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Slfn10provided by MGI
    Official Full Name
    schlafen 10provided by MGI
    Primary source
    MGI:MGI:3512288
    See related
    Ensembl:ENSMUSG00000111713 AllianceGenome:MGI:3512288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slfn10-ps; mFLJ00257
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Slfn10 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82918949..82931359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83028123..83040533, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 8 Neighboring gene STARR-seq mESC enhancer starr_30184 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10699 Neighboring gene STARR-positive B cell enhancer ABC_E8434 Neighboring gene STARR-positive B cell enhancer ABC_E7028 Neighboring gene STARR-positive B cell enhancer ABC_E5255 Neighboring gene STARR-positive B cell enhancer mm9_chr11:82877709-82878010 Neighboring gene predicted gene, 20234 Neighboring gene STARR-seq mESC enhancer starr_30185 Neighboring gene schlafen 2 Neighboring gene STARR-seq mESC enhancer starr_30186 Neighboring gene predicted gene, 53233 Neighboring gene schlafen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Geserick P, et al. Int Immunol, 2004 Oct. PMID 15351786
    2. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Clone Names

    • FLJ00257

    General protein information

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    Preferred Names
    schlafen 10
    Names
    Schlafen family member 10 homologue
    schlafen 10, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355513.1 → NP_001342442.1  schlafen 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the protein-coding allele present in the CAST/EiJ strain genome.
      Source sequence(s)
      LT629148
      UniProtKB/TrEMBL
      A0A1G5SJ64, A0A1G5SJ80
      Conserved Domains (3) summary
      cl22977
      Location:870 → 913
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl26594
      Location:613 → 779
      DUF2075; Uncharacterized conserved protein (DUF2075)
      cl27772
      Location:64 → 363
      B3R; Poxviridae B3 protein

    RNA

    1. NR_073523.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK220241, BP765349
      Related
      ENSMUST00000100716.12

    2. NR_073524.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, noncoding) represents the non-functional allele found in the reference genome and uses an alternate 5' terminal exon compared to variant 1.
      Source sequence(s)
      AK041394, AY261802, BP765349

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82918949..82931359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181542.4: Suppressed sequence

      Description
      NM_181542.4: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version

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