Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chchd7provided by MGI
Official Full Name: coiled-coil-helix-coiled-coil-helix domain containing 7provided by MGI
Primary source: MGI:MGI:1913683
See related: Ensembl:ENSMUSG00000042198 AllianceGenome:MGI:1913683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810049H20Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex assembly. Located in mitochondrion. Orthologous to human CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 11.3), adrenal adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 2.2 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (3938847..3951382)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (3938840..3951383)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial respiratory chain complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coiled-coil-helix-coiled-coil-helix domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190322.2 → NP_001177251.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7

See identical proteins and their annotated locations for NP_001177251.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 5 all encode the same protein.

Source sequence(s)

AI851035, AK003308, AK168647

Consensus CDS

CCDS38686.1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Related

ENSMUSP00000112967.2, ENSMUST00000121651.8

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001190323.2 → NP_001177252.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7

See identical proteins and their annotated locations for NP_001177252.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 5 all encode the same protein.

Source sequence(s)

AI851035, AK003308

Consensus CDS

CCDS38686.1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Related

ENSMUSP00000104023.2, ENSMUST00000108386.8

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001190324.2 → NP_001177253.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7

See identical proteins and their annotated locations for NP_001177253.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 5 all encode the same protein.

Source sequence(s)

AK003308, BX527959

Consensus CDS

CCDS38686.1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Related

ENSMUSP00000118311.2, ENSMUST00000149544.8

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_001285804.1 → NP_001272733.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7

See identical proteins and their annotated locations for NP_001272733.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 5 all encode the same protein.

Source sequence(s)

AI851035, AK003308, CB057699

Consensus CDS

CCDS38686.1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
NM_181391.4 → NP_852056.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7

See identical proteins and their annotated locations for NP_852056.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the supported protein. Variants 1 through 5 all encode the same protein.

Source sequence(s)

AI851035, AK003308, AK007844

Consensus CDS

CCDS38686.1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Related

ENSMUSP00000041196.5, ENSMUST00000041122.11

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RNA

NR_104354.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AI851035, AK003308, AK169018

Related

ENSMUST00000120732.8
NR_104355.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) includes additional 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK003308, AL807387
NR_104356.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) is shorter at the 5' end and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI851035, AK168647, AL807387, BY578448

Related

ENSMUST00000131746.2
NR_104357.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AI851035, AK003308, AK168647, AV042014

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

3938847..3951382

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320349.3 → XP_017175838.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 7 isoform X1

UniProtKB/Swiss-Prot

Q3TGP4, Q8K2Q5

UniProtKB/TrEMBL

B1AXC8

Conserved Domains (1) summary

cl02794
Location:14 → 64

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...