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    Zfp804a zinc finger protein 804A [ Mus musculus (house mouse) ]

    Gene ID: 241514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp804aprovided by MGI
    Official Full Name
    zinc finger protein 804Aprovided by MGI
    Primary source
    MGI:MGI:2442949
    See related
    Ensembl:ENSMUSG00000070866 AllianceGenome:MGI:2442949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf804a; C630007C17Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of dendritic spine maintenance; positive regulation of gene expression; and positive regulation of neuron projection development. Predicted to be located in several cellular components, including dendrite; growth cone; and neuronal cell body. Predicted to be active in nucleus. Is expressed in nervous system; tongue; and urogenital sinus. Used to study schizophrenia. Orthologous to human ZNF804A (zinc finger protein 804A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 2.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp804a in Genome Data Viewer
    Location:
    2 D; 2 49.06 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (81880473..82090223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (82050129..82259879)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04956 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene STARR-seq mESC enhancer starr_04957 Neighboring gene STARR-seq mESC enhancer starr_04958 Neighboring gene predicted gene, 23452 Neighboring gene STARR-seq mESC enhancer starr_04959 Neighboring gene STARR-seq mESC enhancer starr_04960 Neighboring gene STARR-seq mESC enhancer starr_04961 Neighboring gene STARR-seq mESC enhancer starr_04962 Neighboring gene STARR-seq mESC enhancer starr_04963 Neighboring gene STARR-seq mESC enhancer starr_04964 Neighboring gene STARR-seq mESC enhancer starr_04965 Neighboring gene STARR-seq mESC enhancer starr_04967 Neighboring gene STARR-seq mESC enhancer starr_04968 Neighboring gene STARR-seq mESC enhancer starr_04969 Neighboring gene predicted gene 13677 Neighboring gene STARR-seq mESC enhancer starr_04970 Neighboring gene STARR-seq mESC enhancer starr_04971 Neighboring gene RIKEN cDNA A130030D18 gene Neighboring gene mitochondrial ribosomal protein L18 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development. Dong F, et al. Mol Brain, 2021 Jan 14. PMID 33446247, Free PMC Article
    2. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. Huang Y, et al. Mol Psychiatry, 2021 Jun. PMID 33303946, Free PMC Article
    3. Histone H3.3 maintains genome integrity during mammalian development. Jang CW, et al. Genes Dev, 2015 Jul 1. PMID 26159997, Free PMC Article
    4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
      Title: ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.
    2. Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.
      Title: Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 804A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175513.3 → NP_780722.2  zinc finger protein 804A

      See identical proteins and their annotated locations for NP_780722.2

      Status: VALIDATED

      Source sequence(s)
      AK035949, AK049881, BC035535
      Consensus CDS
      CCDS38160.1
      UniProtKB/Swiss-Prot
      A2AKY4, Q8BHY7
      Related
      ENSMUSP00000041941.8, ENSMUST00000047527.8
      Conserved Domains (1) summary
      pfam12171
      Location:57 → 84
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      81880473..82090223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239522.3 → XP_011237824.1  zinc finger protein 804A isoform X1

      Conserved Domains (1) summary
      pfam12171
      Location:57 → 84
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AKY4.1 GenPept UniProtKB/Swiss-Prot:A2AKY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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