U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Capns2 calpain, small subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 69543, updated on 9-Dec-2024

    Summary

    Official Symbol
    Capns2provided by MGI
    Official Full Name
    calpain, small subunit 2provided by MGI
    Primary source
    MGI:MGI:1916793
    See related
    Ensembl:ENSMUSG00000078144 AllianceGenome:MGI:1916793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    30K-2; 2310005G05Rik
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be part of calpain complex. Orthologous to human CAPNS2 (calpain small subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Capns2 in Genome Data Viewer
    Location:
    8 C5; 8 44.99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93628023..93629037)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (92901395..92902409)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_22323 Neighboring gene STARR-seq mESC enhancer starr_22325 Neighboring gene STARR-seq mESC enhancer starr_22326 Neighboring gene matrix metallopeptidase 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene STARR-seq mESC enhancer starr_22327 Neighboring gene predicted gene 2947 Neighboring gene solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium-dependent cysteine-type endopeptidase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of calpain complex  
    located_in cytoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    calpain small subunit 2
    Names
    CSS2
    calcium-dependent protease small subunit 2
    NP_081388.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027112.1NP_081388.1  calpain small subunit 2

      See identical proteins and their annotated locations for NP_081388.1

      Status: VALIDATED

      Source sequence(s)
      AA612262, AK009171, BB571460
      Consensus CDS
      CCDS52634.1
      UniProtKB/Swiss-Prot
      Q9D7J7
      Related
      ENSMUSP00000100553.3, ENSMUST00000104947.5
      Conserved Domains (2) summary
      pfam13499
      Location:154209
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:123168
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      93628023..93629037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.