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    Elob elongin B [ Mus musculus (house mouse) ]

    Gene ID: 67673, updated on 4-Jan-2025

    Summary

    Official Symbol
    Elobprovided by MGI
    Official Full Name
    elongin Bprovided by MGI
    Primary source
    MGI:MGI:1914923
    See related
    Ensembl:ENSMUSG00000055839 AllianceGenome:MGI:1914923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tceb2; 0610040H15Rik
    Summary
    Predicted to enable transcription coactivator activity; transcription corepressor binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in target-directed miRNA degradation and transcription initiation at RNA polymerase II promoter. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in brain; brown fat; dorsal root ganglion; genitourinary system; and limb. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 383.1), large intestine adult (RPKM 213.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Elob in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24043714..24048083, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23824740..23829109, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52285 Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene microRNA 5125 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene serine protease 33 Neighboring gene serine protease 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables transcription coactivator activity  
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul5-RING ubiquitin ligase complex PubMed 
    part_of Cul5-RING ubiquitin ligase complex  
    part_of VCB complex  
    part_of VCB complex  
    part_of VCB complex  
    located_in cytosol  
    part_of elongin complex  
    part_of elongin complex PubMed 
    part_of elongin complex  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    elongin-B
    Names
    18 kDa, elongin B
    RNA polymerase II transcription factor SIII subunit B
    SIII p18
    elongin 18 kDa subunit
    transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B)
    transcription elongation factor B polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026305.2NP_080581.1  elongin-B

      See identical proteins and their annotated locations for NP_080581.1

      Status: PROVISIONAL

      Source sequence(s)
      AK002868
      Consensus CDS
      CCDS57055.1
      UniProtKB/Swiss-Prot
      P62869, Q63529, Q80W20
      Related
      ENSMUSP00000066210.6, ENSMUST00000069579.7
      Conserved Domains (1) summary
      cd01788
      Location:2102
      Ubl_ElonginB; ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24043714..24048083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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