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    Trp53 transformation related protein 53 [ Mus musculus (house mouse) ]

    Gene ID: 22059, updated on 24-Dec-2024

    Summary

    Official Symbol
    Trp53provided by MGI
    Official Full Name
    transformation related protein 53provided by MGI
    Primary source
    MGI:MGI:98834
    See related
    Ensembl:ENSMUSG00000059552 AllianceGenome:MGI:98834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bbl; bfy; bhy; p44; p53; Tp53
    Summary
    This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thymus adult (RPKM 69.1), ovary adult (RPKM 56.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trp53 in Genome Data Viewer
    Location:
    11 B3; 11 42.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69471174..69482699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69580348..69591873)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_29852 Neighboring gene STARR-seq mESC enhancer starr_29854 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10681 Neighboring gene sex hormone binding globulin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 66
    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables ATP-dependent DNA/DNA annealing activity  
    enables ATP-dependent DNA/DNA annealing activity  
    enables DNA binding  
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables MDM2/MDM4 family protein binding PubMed 
    enables MDM2/MDM4 family protein binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables TFIID-class transcription factor complex binding  
    enables TFIID-class transcription factor complex binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables copper ion binding  
    enables copper ion binding  
    enables core promoter sequence-specific DNA binding  
    enables core promoter sequence-specific DNA binding  
    enables disordered domain specific binding  
    enables disordered domain specific binding  
    enables enzyme binding  
    enables general transcription initiation factor binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables histone deacetylase regulator activity PubMed 
    enables identical protein binding  
    enables identical protein binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables molecular condensate scaffold activity  
    enables molecular function activator activity  
    enables molecular function activator activity  
    enables p53 binding  
    enables p53 binding  
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein phosphatase 2A binding  
    enables protein phosphatase 2A binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables receptor tyrosine kinase binding  
    enables receptor tyrosine kinase binding  
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coregulator binding  
    enables transmembrane transporter binding  
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 66
    Items 1 - 25 of 241
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell lineage commitment PubMed 
    acts_upstream_of_or_within DNA damage response PubMed 
    acts_upstream_of_or_within DNA damage response PubMed 
    acts_upstream_of_or_within DNA damage response  
    involved_in DNA damage response  
    involved_in DNA damage response PubMed 
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator PubMed 
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator  
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  
    acts_upstream_of_or_within ER overload response  
    involved_in Ras protein signal transduction  
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell lineage commitment PubMed 
    acts_upstream_of_or_within T cell proliferation involved in immune response PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    acts_upstream_of apoptotic process PubMed 
    involved_in apoptotic process PubMed 
    involved_in apoptotic signaling pathway  
    involved_in autophagy  
    involved_in bone marrow development  
    involved_in bone marrow development  
    acts_upstream_of cardiac muscle cell apoptotic process PubMed 
    acts_upstream_of_or_within cardiac septum morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cellular response to UV PubMed 
    acts_upstream_of_or_within cellular response to UV PubMed 
    involved_in cellular response to UV  
    acts_upstream_of_or_within cellular response to UV-C PubMed 
    involved_in cellular response to actinomycin D  
    involved_in cellular response to actinomycin D  
    acts_upstream_of_or_within cellular response to gamma radiation PubMed 
    involved_in cellular response to gamma radiation  
    acts_upstream_of_or_within cellular response to glucose starvation  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to ionizing radiation PubMed 
    acts_upstream_of_or_within cellular response to ionizing radiation PubMed 
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to reactive oxygen species  
    acts_upstream_of_or_within cellular response to stress PubMed 
    involved_in cellular response to xenobiotic stimulus  
    involved_in cellular senescence  
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within cerebellum development PubMed 
    acts_upstream_of_or_within chromosome organization PubMed 
    involved_in circadian behavior PubMed 
    involved_in circadian rhythm PubMed 
    involved_in determination of adult lifespan PubMed 
    acts_upstream_of_or_within double-strand break repair PubMed 
    acts_upstream_of_or_within embryo development ending in birth or egg hatching PubMed 
    acts_upstream_of_or_within embryonic organ development PubMed 
    involved_in entrainment of circadian clock by photoperiod PubMed 
    acts_upstream_of fibroblast proliferation PubMed 
    acts_upstream_of_or_within fibroblast proliferation PubMed 
    acts_upstream_of fibroblast proliferation PubMed 
    acts_upstream_of_or_within gastrulation PubMed 
    acts_upstream_of glial cell proliferation PubMed 
    acts_upstream_of glucose catabolic process to lactate via pyruvate PubMed 
    acts_upstream_of_or_within heart development PubMed 
    involved_in hematopoietic progenitor cell differentiation  
    involved_in hematopoietic stem cell differentiation  
    involved_in hematopoietic stem cell differentiation  
    NOT acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to hypoxia PubMed 
    involved_in mRNA transcription  
    involved_in mRNA transcription  
    acts_upstream_of_or_within mitochondrial DNA repair PubMed 
    acts_upstream_of mitophagy PubMed 
    acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling PubMed 
    involved_in mitotic G1 DNA damage checkpoint signaling  
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within necroptotic process PubMed 
    involved_in negative regulation of DNA biosynthetic process  
    acts_upstream_of_or_within negative regulation of DNA replication PubMed 
    acts_upstream_of_or_within negative regulation of DNA replication PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of G1 to G0 transition  
    involved_in negative regulation of G1 to G0 transition  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    acts_upstream_of negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation PubMed 
    involved_in negative regulation of fibroblast proliferation  
    acts_upstream_of_or_within negative regulation of gene expression PubMed 
    acts_upstream_of_or_within negative regulation of glial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate PubMed 
    acts_upstream_of_or_within negative regulation of miRNA processing PubMed 
    acts_upstream_of_or_within negative regulation of mitophagy PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle PubMed 
    acts_upstream_of_or_within negative regulation of neuroblast proliferation PubMed 
    involved_in negative regulation of pentose-phosphate shunt  
    involved_in negative regulation of pentose-phosphate shunt  
    acts_upstream_of_or_within negative regulation of proteolysis PubMed 
    acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process PubMed 
    involved_in negative regulation of smooth muscle cell proliferation  
    acts_upstream_of_or_within negative regulation of stem cell proliferation PubMed 
    involved_in negative regulation of telomere maintenance via telomerase  
    involved_in negative regulation of telomere maintenance via telomerase  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of neuroblast proliferation PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron apoptotic process PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron apoptotic process PubMed 
    involved_in nucleotide-excision repair  
    involved_in nucleotide-excision repair  
    involved_in oligodendrocyte apoptotic process  
    involved_in oligodendrocyte apoptotic process  
    involved_in oxidative stress-induced premature senescence  
    involved_in oxidative stress-induced premature senescence  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly  
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process PubMed 
    involved_in positive regulation of cell cycle  
    acts_upstream_of_or_within positive regulation of cellular senescence PubMed 
    involved_in positive regulation of cellular senescence PubMed 
    involved_in positive regulation of cellular senescence  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of leukocyte migration  
    involved_in positive regulation of miRNA transcription  
    acts_upstream_of_or_within positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability PubMed 
    acts_upstream_of_or_within positive regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of programmed necrotic cell death PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    acts_upstream_of_or_within positive regulation of thymocyte apoptotic process PubMed 
    involved_in positive regulation of thymocyte apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    involved_in protein localization  
    acts_upstream_of_or_within protein stabilization PubMed 
    involved_in protein tetramerization  
    involved_in protein-containing complex assembly  
    acts_upstream_of_or_within rRNA transcription PubMed 
    acts_upstream_of reactive oxygen species metabolic process PubMed 
    acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of apoptotic process  
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    acts_upstream_of regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle G2/M phase transition  
    acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of cellular senescence PubMed 
    acts_upstream_of_or_within regulation of fibroblast apoptotic process PubMed 
    involved_in regulation of intracellular pH  
    acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within regulation of thymocyte apoptotic process PubMed 
    acts_upstream_of_or_within regulation of tissue remodeling PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within release of cytochrome c from mitochondria PubMed 
    acts_upstream_of_or_within release of cytochrome c from mitochondria PubMed 
    involved_in replicative senescence  
    involved_in replicative senescence  
    acts_upstream_of_or_within response to UV PubMed 
    acts_upstream_of_or_within response to UV PubMed 
    acts_upstream_of_or_within response to X-ray PubMed 
    acts_upstream_of_or_within response to X-ray PubMed 
    involved_in response to X-ray  
    acts_upstream_of_or_within response to gamma radiation PubMed 
    acts_upstream_of_or_within response to gamma radiation PubMed 
    involved_in response to gamma radiation  
    acts_upstream_of_or_within response to ischemia PubMed 
    acts_upstream_of_or_within response to oxidative stress PubMed 
    acts_upstream_of_or_within response to oxidative stress PubMed 
    acts_upstream_of_or_within response to salt stress PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within signal transduction by p53 class mediator PubMed 
    involved_in signal transduction by p53 class mediator  
    acts_upstream_of_or_within somitogenesis PubMed 
    involved_in spermatogenesis  
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of thymocyte apoptotic process PubMed 
    involved_in transcription initiation-coupled chromatin remodeling  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in type II interferon-mediated signaling pathway PubMed 
    involved_in viral process  
    involved_in viral process  
    Items 1 - 25 of 241
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    located_in PML body  
    located_in PML body  
    part_of RNA polymerase II transcription regulator complex  
    located_in centrosome  
    located_in centrosome  
    located_in chromatin  
    located_in chromatin PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in endoplasmic reticulum  
    located_in germ cell nucleus PubMed 
    located_in mitochondrial matrix PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    colocalizes_with nuclear body  
    located_in nuclear matrix  
    located_in nuclear matrix  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex  
    located_in replication fork PubMed 
    located_in site of double-strand break PubMed 
    part_of transcription regulator complex  
    part_of transcription repressor complex  
    part_of transcription repressor complex  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    cellular tumor antigen p53
    Names
    ME-delta123p53
    mutant p53
    p53 cellular tumor antigen
    tumor suppressor p53
    tumor supressor p53

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127233.2NP_001120705.1  cellular tumor antigen p53 isoform b

      See identical proteins and their annotated locations for NP_001120705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site for the 3' exon, as compared to variant 1. The resulting isoform (b), also known p53AS, has a shorter and different C-terminus, as compared to isoform a.
      Source sequence(s)
      AL731687
      Consensus CDS
      CCDS48826.1
      UniProtKB/TrEMBL
      I7HIK9, Q80ZA1
      Related
      ENSMUSP00000127130.2, ENSMUST00000171247.8
      Conserved Domains (3) summary
      cd08367
      Location:106286
      P53; P53 DNA-binding domain
      pfam07710
      Location:316352
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:931
      P53_TAD; P53 transactivation motif
    2. NM_011640.4NP_035770.2  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_035770.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL731687
      Consensus CDS
      CCDS36193.1
      UniProtKB/Swiss-Prot
      P02340, Q9QUP3
      UniProtKB/TrEMBL
      A0A158SIS7, Q549C9
      Related
      ENSMUSP00000104298.4, ENSMUST00000108658.10
      Conserved Domains (3) summary
      cd08367
      Location:106286
      P53; P53 DNA-binding domain
      pfam07710
      Location:316352
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:931
      P53_TAD; P53 transactivation motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69471174..69482699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245922.1XP_030101782.1  cellular tumor antigen p53 isoform X1

      UniProtKB/Swiss-Prot
      P02340, Q9QUP3
      UniProtKB/TrEMBL
      A0A158SIS7, Q549C9
      Conserved Domains (3) summary
      cd08367
      Location:106286
      P53; P53 DNA-binding domain
      pfam07710
      Location:316352
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:931
      P53_TAD; P53 transactivation motif
    2. XM_030245923.2XP_030101783.1  cellular tumor antigen p53 isoform X2

      UniProtKB/TrEMBL
      I7HIK9, Q80ZA1
      Conserved Domains (3) summary
      cd08367
      Location:106286
      P53; P53 DNA-binding domain
      pfam07710
      Location:316352
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:931
      P53_TAD; P53 transactivation motif
    3. XM_006533157.5XP_006533220.1  cellular tumor antigen p53 isoform X1

      See identical proteins and their annotated locations for XP_006533220.1

      UniProtKB/Swiss-Prot
      P02340, Q9QUP3
      UniProtKB/TrEMBL
      A0A158SIS7, Q549C9
      Conserved Domains (3) summary
      cd08367
      Location:106286
      P53; P53 DNA-binding domain
      pfam07710
      Location:316352
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:931
      P53_TAD; P53 transactivation motif
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