Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dync1li1provided by MGI
Official Full Name: dynein cytoplasmic 1 light intermediate chain 1provided by MGI
Primary source: MGI:MGI:2135610
See related: Ensembl:ENSMUSG00000032435 AllianceGenome:MGI:2135610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlic1; LIC-1; Dnclic1; 1110053F02Rik
Summary: Predicted to enable several functions, including GDP binding activity; dynein heavy chain binding activity; and identical protein binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; early endosome to recycling endosome transport; and regulation of cell cycle process. Predicted to be located in cytoplasmic vesicle; kinetochore; and spindle pole. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 27.9), CNS E14 (RPKM 23.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 64.96 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (114517899..114552856)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (114688831..114723788)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes.
Title: Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes.
the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons.
Title: Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling.
Light intermediate chain 1 is required for single-cell polarization and directional cell motility.
Title: SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Gene trapped (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	IEA Inferred from Electronic Annotation more info
enables dynein heavy chain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in early endosome to recycling endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule-based movement	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in microtubule-based movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoplasmic dynein 1 light intermediate chain 1

Names: DLC-A; dynein light chain A; dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146229.2 → NP_666341.1 cytoplasmic dynein 1 light intermediate chain 1

See identical proteins and their annotated locations for NP_666341.1

Status: PROVISIONAL

Source sequence(s)

AC161419

Consensus CDS

CCDS23595.1

UniProtKB/Swiss-Prot

Q8R1Q8

UniProtKB/TrEMBL

Q3TWG5

Related

ENSMUSP00000035366.7, ENSMUST00000047404.7

Conserved Domains (2) summary

pfam05783
Location:43 → 519

DLIC; Dynein light intermediate chain (DLIC)

cl21455
Location:70 → 302

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases