Adad1 adenosine deaminase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adad1provided by MGI
Official Full Name: adenosine deaminase domain containing 1provided by MGI
Primary source: MGI:MGI:103258
See related: Ensembl:ENSMUSG00000027719 AllianceGenome:MGI:103258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tenr
Summary: Enables RNA binding activity. Involved in spermatid development. Located in male germ cell nucleus. Is expressed in brain; genitourinary system; and sensory organ. Orthologous to human ADAD1 (adenosine deaminase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 32.6) See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.3 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37117805..37165661)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37063656..37111512)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculusdagger.
Title: ADAD1 is required for normal translation of nuclear pore and transport protein transcripts in spermatids of Mus musculus†.
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
Targeted mutation of the Tenr gene causes male sterility. Tenr mutant males have a reduced sperm count, and Tenr-/- sperm show a decrease in motility and an increase in malformed heads.
Title: Disruption of murine Tenr results in teratospermia and male infertility.
2.65 A crystal structure of mouse TB-RBP
Title: Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

mTenr (e-PCR)
- UniSTS:514595

Adad1 (e-PCR), detects polymorphism
- UniSTS:479046

Tenr (e-PCR)
- UniSTS:503372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenosine deaminase domain-containing protein 1

Names: adenosine deaminase domain containing 1 (testis specific); testis nuclear RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009350.3 → NP_033376.2 adenosine deaminase domain-containing protein 1

See identical proteins and their annotated locations for NP_033376.2

Status: VALIDATED

Source sequence(s)

AL662823

Consensus CDS

CCDS17315.1

UniProtKB/Swiss-Prot

A2AAD7, A2AAD8, A2AAV1, Q08EL2, Q3V0N7, Q5SUE7, Q62309, Q9JLB6

UniProtKB/TrEMBL

F8WI80

Related

ENSMUSP00000115260.2, ENSMUST00000144629.8

Conserved Domains (2) summary

smart00358
Location:139 → 204

DSRM; Double-stranded RNA binding motif

smart00552
Location:246 → 618

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)