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    Gmppa GDP-mannose pyrophosphorylase A [ Mus musculus (house mouse) ]

    Gene ID: 69080, updated on 27-Dec-2024

    Summary

    Official Symbol
    Gmppaprovided by MGI
    Official Full Name
    GDP-mannose pyrophosphorylase Aprovided by MGI
    Primary source
    MGI:MGI:1916330
    See related
    Ensembl:ENSMUSG00000033021 AllianceGenome:MGI:1916330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810012N01Rik
    Summary
    Predicted to enable enzyme regulator activity and molecular sensor activity. Involved in negative regulation of metabolic process. Acts upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and gonad. Used to study alacrima, achalasia, and impaired intellectual development syndrome. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 59.3), large intestine adult (RPKM 50.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gmppa in Genome Data Viewer
    Location:
    1 C4; 1 39.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75412555..75419823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75435911..75443179)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene desmin Neighboring gene predicted gene 15179 Neighboring gene SPEG complex locus Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene predicted gene, 53564 Neighboring gene acid-sensing ion channel family member 4 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene transmembrane protein 198 Neighboring gene chondroitin polymerizing factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding  
    enables enzyme inhibitor activity  
    enables enzyme regulator activity PubMed 
    enables molecular sensor activity PubMed 
    enables molecular_function  
    enables transferase activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GDP-mannose biosynthetic process PubMed 
    acts_upstream_of_or_within GDP-mannose metabolic process PubMed 
    acts_upstream_of_or_within cognition PubMed 
    acts_upstream_of_or_within glycoprotein metabolic process PubMed 
    acts_upstream_of_or_within motor behavior PubMed 
    acts_upstream_of_or_within muscle organ morphogenesis PubMed 
    involved_in negative regulation of biosynthetic process PubMed 
    involved_in negative regulation of nucleobase-containing compound metabolic process PubMed 
    involved_in negative regulation of phosphate metabolic process PubMed 
    involved_in negative regulation of small molecule metabolic process PubMed 
    acts_upstream_of_or_within neuromuscular process PubMed 
    acts_upstream_of_or_within neuron apoptotic process PubMed 
    acts_upstream_of_or_within protein glycosylation PubMed 
    acts_upstream_of_or_within skeletal muscle organ development PubMed 
    acts_upstream_of_or_within telencephalon development PubMed 
    Component Evidence Code Pubs
    part_of GDP-mannose pyrophosphorylase complex  
    is_active_in cytoplasm  
    is_active_in cytosol PubMed 

    General protein information

    Preferred Names
    mannose-1-phosphate guanylyltransferase regulatory subunit alpha; mannose-1-phosphate guanyltransferase alpha
    Names
    GTP-mannose-1-phosphate guanylyltransferase alpha
    NP_001344098.1
    NP_001344099.1
    NP_001344100.1
    NP_598469.1
    XP_006496594.1
    XP_006496595.1
    XP_006496598.1
    XP_006496601.1
    XP_011237010.1
    XP_030098600.1
    XP_030098602.1
    XP_030098613.1
    XP_030098616.1
    XP_036009310.1
    XP_036009312.1
    XP_036009313.1
    XP_036009316.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357169.2NP_001344098.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      Consensus CDS
      CCDS15072.1
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
      Related
      ENSMUSP00000109214.2, ENSMUST00000113584.8
      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    2. NM_001357170.2NP_001344099.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      Consensus CDS
      CCDS15072.1
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    3. NM_001357171.2NP_001344100.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    4. NM_001432705.1NP_001419634.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    5. NM_001432706.1NP_001419635.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    6. NM_001432708.1NP_001419637.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    7. NM_001432709.1NP_001419638.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    8. NM_001432710.1NP_001419639.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    9. NM_001432711.1NP_001419640.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    10. NM_001432713.1NP_001419642.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    11. NM_001432715.1NP_001419644.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
    12. NM_001432716.1NP_001419645.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/TrEMBL
      Q3UNC0
    13. NM_001432718.1NP_001419647.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114651
      UniProtKB/TrEMBL
      Q3UNC0
    14. NM_133708.5NP_598469.1  mannose-1-phosphate guanylyltransferase regulatory subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_598469.1

      Status: VALIDATED

      Source sequence(s)
      AC114651
      Consensus CDS
      CCDS15072.1
      UniProtKB/Swiss-Prot
      Q3UCM2, Q922H4
      UniProtKB/TrEMBL
      Q3UNC0
      Related
      ENSMUSP00000035564.8, ENSMUST00000037796.14
      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75412555..75419823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496532.2XP_006496595.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006496595.1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    2. XM_030242756.1XP_030098616.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    3. XM_030242740.1XP_030098600.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    4. XM_036153419.1XP_036009312.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    5. XM_011238708.1XP_011237010.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_011237010.1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    6. XM_006496531.1XP_006496594.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006496594.1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    7. XM_006496538.1XP_006496601.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    8. XM_030242753.1XP_030098613.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    9. XM_030242742.2XP_030098602.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    10. XM_036153420.1XP_036009313.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    11. XM_036153417.1XP_036009310.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    12. XM_036153423.1XP_036009316.1  mannose-1-phosphate guanyltransferase alpha isoform X2

      Conserved Domains (2) summary
      cd06428
      Location:4261
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:289355
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    13. XM_006496535.3XP_006496598.1  mannose-1-phosphate guanyltransferase alpha isoform X1

      See identical proteins and their annotated locations for XP_006496598.1

      UniProtKB/TrEMBL
      Q3UNC0
      Conserved Domains (2) summary
      cd06428
      Location:4266
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      cl00160
      Location:294360
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
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