Mapkap1 mitogen-activated protein kinase associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapkap1provided by MGI
Official Full Name: mitogen-activated protein kinase associated protein 1provided by MGI
Primary source: MGI:MGI:2444554
See related: Ensembl:ENSMUSG00000038696 AllianceGenome:MGI:2444554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sin1; D230039K05Rik
Summary: Predicted to enable several functions, including enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Involved in positive regulation of peptidyl-serine phosphorylation and regulation of cellular response to oxidative stress. Part of TORC2 complex. Is expressed in several structures, including genitourinary system; gut gland; heart; nervous system; and trachea. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 15.7), CNS E14 (RPKM 14.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.84 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (34296783..34514970)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (34406771..34624958)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet beta Cells.
Title: Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet β Cells.
MicroRNA-7a inhibits Isl1 expression to regulate insulin secretion by targeting Raf1 and Mapkap1 in NIT-1 cells.
Title: MicroRNA-7a inhibits Isl1 expression to regulate insulin secretion by targeting Raf1 and Mapkap1 in NIT-1 cells.
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.
Title: Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.
Sin1 is an amplifier of platelet alphaIIbbeta3-mediated outsidein signaling and a susceptible sensor of hypoxia/ROS signaling in ischemic environments after myocardial infarction, inducing microthrombosis.
Title: Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets.
In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer.
Title: Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
This study provides evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for Interferon-gamma-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors.
Title: Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.
analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
Title: Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.
data suggest that DNA-PKcs-SIN1 complexation-mediated Akt activation (Ser-473 phosphorylation) is required for mouse osteoblast differentiation
Title: DNA-PKcs-SIN1 complexation mediates low-dose X-ray irradiation (LDI)-induced Akt activation and osteoblast differentiation.
these findings provide evidence for critical functions for Rictor/Sin1 complexes in type I IFN signaling and the generation of type I IFN antineoplastic responses.
Title: Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses.
The phosphorylation of SIN1 by Akt was found to regulate mTORC2 activity in response to growth factors, revealing topological insights into the Akt/mTOR signaling network.
Title: Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI591529 (e-PCR)
- UniSTS:165164

D2Mit204 (e-PCR), detects polymorphism
- UniSTS:129076

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: target of rapamycin complex 2 subunit MAPKAP1

Names: SAPK-interacting protein 1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; stress-activated map kinase-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290625.1 → NP_001277554.1 target of rapamycin complex 2 subunit MAPKAP1 isoform a

See identical proteins and their annotated locations for NP_001277554.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).

Source sequence(s)

AK132263, AL808102, AL845262, BC090644

Consensus CDS

CCDS15948.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Related

ENSMUSP00000108751.2, ENSMUST00000113126.3

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
NM_001290626.1 → NP_001277555.1 target of rapamycin complex 2 subunit MAPKAP1 isoform b

See identical proteins and their annotated locations for NP_001277555.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon and it thus differs in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).

Source sequence(s)

AK042154, AL845262, BB852269, BC090644

Consensus CDS

CCDS71035.1

UniProtKB/TrEMBL

A2AR15

Related

ENSMUSP00000123301.2, ENSMUST00000124443.8

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
NM_001362919.1 → NP_001349848.1 target of rapamycin complex 2 subunit MAPKAP1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).

Source sequence(s)

AL808102, AL845262

Consensus CDS

CCDS15948.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
NM_001362920.1 → NP_001349849.1 target of rapamycin complex 2 subunit MAPKAP1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).

Source sequence(s)

AL808102, AL845262

Consensus CDS

CCDS71035.1

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
NM_001362921.1 → NP_001349850.1 target of rapamycin complex 2 subunit MAPKAP1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL808102, AL845262

Consensus CDS

CCDS89477.1

Related

ENSMUSP00000108749.2, ENSMUST00000113124.8

Conserved Domains (3) summary

cd13331
Location:347 → 454

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
NM_177345.4 → NP_796319.1 target of rapamycin complex 2 subunit MAPKAP1 isoform a

See identical proteins and their annotated locations for NP_796319.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).

Source sequence(s)

AK042154, AK052045, AL845262, BB852269, BC090644

Consensus CDS

CCDS15948.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Related

ENSMUSP00000116494.2, ENSMUST00000147337.8

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

34296783..34514970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249984.2 → XP_030105844.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_036160892.1 → XP_036016785.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_036160886.1 → XP_036016779.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X3

Conserved Domains (3) summary

cd13331
Location:324 → 431

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_011239084.4 → XP_011237386.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

See identical proteins and their annotated locations for XP_011237386.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249994.2 → XP_030105854.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X3

Conserved Domains (3) summary

cd13331
Location:324 → 431

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_036160887.1 → XP_036016780.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (3) summary

cd13331
Location:288 → 395

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249997.2 → XP_030105857.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250001.1 → XP_030105861.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250011.2 → XP_030105871.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X7

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:132 → 239

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 32

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250003.2 → XP_030105863.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X6

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:155 → 262

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249979.2 → XP_030105839.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249999.2 → XP_030105859.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_036160899.1 → XP_036016792.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249998.1 → XP_030105858.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_006497983.3 → XP_006498046.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X5

See identical proteins and their annotated locations for XP_006498046.1

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249991.2 → XP_030105851.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X3

Conserved Domains (3) summary

cd13331
Location:324 → 431

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_006497978.5 → XP_006498041.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X2

UniProtKB/Swiss-Prot

Q8BKH7

Conserved Domains (3) summary

cd13331
Location:347 → 454

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_006497980.5 → XP_006498043.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X3

Conserved Domains (3) summary

cd13331
Location:324 → 431

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030249995.2 → XP_030105855.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (3) summary

cd13331
Location:288 → 395

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 224

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250002.2 → XP_030105862.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X6

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:155 → 262

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_036160901.1 → XP_036016794.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X7

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:132 → 239

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 32

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_011239083.3 → XP_011237385.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

See identical proteins and their annotated locations for XP_011237385.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250012.2 → XP_030105872.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X7

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:132 → 239

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 32

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_030250004.2 → XP_030105864.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X6

UniProtKB/TrEMBL

A2AR15

Conserved Domains (2) summary

cd13331
Location:155 → 262

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_006497975.2 → XP_006498038.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

See identical proteins and their annotated locations for XP_006498038.1

UniProtKB/Swiss-Prot

A2AN72, A2AN74, A2AR13, A2AR16, Q80UY4, Q8BKH7, Q8BMV5, Q8R2N9

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain