Cdip1 cell death inducing Trp53 target 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdip1provided by MGI
Official Full Name: cell death inducing Trp53 target 1provided by MGI
Primary source: MGI:MGI:1913876
See related: Ensembl:ENSMUSG00000004071 AllianceGenome:MGI:1913876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDIP; 2700048O17Rik; 5730403B10Rik
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to act upstream of or within apoptotic process and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. Is expressed in embryo; otic pit; and otocyst. Orthologous to human CDIP1 (cell death inducing p53 target 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 59.3), testis adult (RPKM 47.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4583325..4608156, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4765461..4790292, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
Title: Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
These findings reveal a novel regulatory pathway that comprises circular transcript of NCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis during ischemic cardiac disease.
Title: A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.
CDIP1 Promotes Bax Oligomerization and Mitochondrial Translocation during endoplasmic reticulum Stress.
Title: CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)

General gene information

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Markers

BB445209 (e-PCR)
- UniSTS:209155

AW742692 (e-PCR)
- UniSTS:209156

MARC_7867-7868:996688114:1 (e-PCR)
- UniSTS:269842

RH136215 (e-PCR)
- UniSTS:210210

RH126260 (e-PCR)
- UniSTS:162968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic side of late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic side of lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell death-inducing p53-target protein 1

Names: LITAF-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358078.1 → NP_001345007.1 cell death-inducing p53-target protein 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.

Source sequence(s)

AC166903

Consensus CDS

CCDS27925.1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain
NM_001358079.2 → NP_001345008.1 cell death-inducing p53-target protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC166903

Conserved Domains (1) summary

pfam10601
Location:158 → 224

zf-LITAF-like; LITAF-like zinc ribbon domain
NM_001358080.2 → NP_001345009.1 cell death-inducing p53-target protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC166903

Conserved Domains (1) summary

pfam10601
Location:102 → 168

zf-LITAF-like; LITAF-like zinc ribbon domain
NM_001358081.2 → NP_001345010.1 cell death-inducing p53-target protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC166903

Consensus CDS

CCDS88867.1

Related

ENSMUSP00000113618.2, ENSMUST00000117713.8

Conserved Domains (1) summary

pfam10601
Location:120 → 186

zf-LITAF-like; LITAF-like zinc ribbon domain
NM_001358082.2 → NP_001345011.1 cell death-inducing p53-target protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC166903

Consensus CDS

CCDS27925.1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Related

ENSMUSP00000113889.2, ENSMUST00000118703.8

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain
NM_025670.5 → NP_079946.2 cell death-inducing p53-target protein 1 isoform 4

See identical proteins and their annotated locations for NP_079946.2

Status: VALIDATED

Source sequence(s)

AC166903

Consensus CDS

CCDS27925.1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Related

ENSMUSP00000004173.6, ENSMUST00000004173.12

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

4583325..4608156 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249239.1 → XP_030105099.1 cell death-inducing p53-target protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain
XM_030249240.1 → XP_030105100.1 cell death-inducing p53-target protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain
XM_006522468.1 → XP_006522531.1 cell death-inducing p53-target protein 1 isoform X1

See identical proteins and their annotated locations for XP_006522531.1

UniProtKB/Swiss-Prot

Q3UD73, Q9CYP1, Q9DB75

Conserved Domains (1) summary

pfam10601
Location:137 → 205

zf-LITAF-like; LITAF-like zinc ribbon domain