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    Rpl18 ribosomal protein L18 [ Mus musculus (house mouse) ]

    Gene ID: 19899, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rpl18provided by MGI
    Official Full Name
    ribosomal protein L18provided by MGI
    Primary source
    MGI:MGI:98003
    See related
    Ensembl:ENSMUSG00000059070 AllianceGenome:MGI:98003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L18; Rpl18a
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is expressed in brain. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 264.4), large intestine adult (RPKM 246.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl18 in Genome Data Viewer
    Location:
    7 B3; 7 29.45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45364891..45370255)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45715467..45720835)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene sphingosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52988906-52989102 Neighboring gene sulfotransferase family, cytosolic, 2B, member 1 Neighboring gene predicted gene, 31597 Neighboring gene STARR-seq mESC enhancer starr_18855

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of four mouse ribosomal-protein-L18 genes that appear to be processed pseudogenes. Peled-Yalif E, et al. Gene, 1984 Jul-Aug. PMID 6149171
    2. Gene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene. Molina A, et al. Biochim Biophys Acta, 2001 Sep 21. PMID 11566355
    3. Sequence analysis of mouse cDNAs encoding ribosomal proteins L12 and L18. Hou EW, et al. Gene, 1993 Aug 25. PMID 8359697
    4. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502
    5. Transcriptional and translational regulation of ribosomal protein formation during mouse myoblast differentiation. Agrawal MG, et al. J Biol Chem, 1987 Apr 5. PMID 3558374

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL18
    Names
    60S ribosomal protein L18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417207.1 → NP_001404136.1  large ribosomal subunit protein eL18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167242

    2. NM_009077.3 → NP_033103.2  large ribosomal subunit protein eL18 isoform 1

      See identical proteins and their annotated locations for NP_033103.2

      Status: VALIDATED

      Source sequence(s)
      AC167242
      Consensus CDS
      CCDS39958.1
      UniProtKB/Swiss-Prot
      P35980, Q9CQF1, Q9D987
      UniProtKB/TrEMBL
      Q58EW0, Q642K1
      Related
      ENSMUSP00000072320.7, ENSMUST00000072503.13
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 176
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45364891..45370255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242247.1 → XP_030098107.1  large ribosomal subunit protein eL18 isoform X1

      UniProtKB/Swiss-Prot
      P35980, Q9CQF1, Q9D987
      UniProtKB/TrEMBL
      Q58EW0, Q642K1
      Related
      ENSMUSP00000147816.2, ENSMUST00000210640.2
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 176
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

    2. XM_017322049.3 → XP_017177538.1  large ribosomal subunit protein eL18 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GQU8, A0A1B0GSF7
      Related
      ENSMUSP00000147918.2, ENSMUST00000209287.2
      Conserved Domains (1) summary
      pfam17135
      Location:1 → 136
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35980.3 GenPept UniProtKB/Swiss-Prot:P35980

    Gene LinkOut

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