Agr2 anterior gradient 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agr2provided by MGI
Official Full Name: anterior gradient 2provided by MGI
Primary source: MGI:MGI:1344405
See related: Ensembl:ENSMUSG00000020581 AllianceGenome:MGI:1344405
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Agr2h; Gob-4; HAG-2; XAG-2; mAG-2
Summary: Predicted to enable dystroglycan binding activity; epidermal growth factor receptor binding activity; and protein homodimerization activity. Involved in digestive tract morphogenesis; mucus secretion; and positive regulation of developmental growth. Acts upstream of or within inflammatory response and lung goblet cell differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; gut; liver; and lung. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 438.3), colon adult (RPKM 350.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 16.18 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (36042924..36054080)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (35992925..36004081)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103[+] dendritic cell IL-23-dependent ileocolitis.
Title: Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103(+) dendritic cell IL-23-dependent ileocolitis.
Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT.
Title: Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT.
Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
Title: Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Title: AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation.
Title: Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation.
Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to beta-catenin that requires AGR2 dimerization and adhesion domains.
Title: Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains.
secretory AGR2 alters fibroblasts elongation, migration, and organization suggesting the secretory AGR2 as a potential molecular target that might be responsible to alter fibroblasts infiltration to support tumor growth.
Title: Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration.
study demonstrates that AGR2 dimers act as sensors of ER homeostasis which are disrupted upon ER stress and promote the secretion of AGR2 monomers.
Title: Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
AGR2 accelerates skin wound healing through regulation of cell migration.
Title: Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.
AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation.
Title: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (9) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dystroglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables dystroglycan binding	IEA Inferred from Electronic Annotation more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell chemotaxis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung goblet cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of IRE1-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of IRE1-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of PERK-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein folding in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: anterior gradient protein 2 homolog

Names: AG-2; anterior gradient 2 homolog; protein Gob-4; secreted cement gland protein XAG-2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011783.2 → NP_035913.1 anterior gradient protein 2 homolog precursor

See identical proteins and their annotated locations for NP_035913.1

Status: PROVISIONAL

Source sequence(s)

CT030196

Consensus CDS

CCDS25881.1

UniProtKB/Swiss-Prot

A2CGA2, O88312

Related

ENSMUSP00000020898.6, ENSMUST00000020898.12

Conserved Domains (1) summary

cd02960
Location:47 → 175

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...