Gigyf2 GRB10 interacting GYF protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gigyf2provided by MGI
Official Full Name: GRB10 interacting GYF protein 2provided by MGI
Primary source: MGI:MGI:2138584
See related: Ensembl:ENSMUSG00000048000 AllianceGenome:MGI:2138584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tnrc15; mKIAA0642; 2610016F01Rik; A830080H02Rik
Summary: Predicted to enable molecular adaptor activity and proline-rich region binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Located in several cellular components, including perikaryon; proximal dendrite; and vesicle. Is expressed in several structures, including central nervous system; genitourinary system; intestine; liver; and lung. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 11.1), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5- D; 1 44.23 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87254653..87378532)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87326931..87450810)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.
Title: Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.
Negative regulation of Grb10 Interacting GIGYF2 protein on IGF-1 receptor signaling pathway caused diabetic mice cognitive impairment.
Title: Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment.
Disruption of the eukaryotic translation initiation factor 4E - Gigyf2 complex leads to increased translation and perinatal lethality in mice.
Title: A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 signaling.
Title: GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.
identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138626 (e-PCR)
- UniSTS:220713

AU024213 (e-PCR)
- UniSTS:207189

Gigyf2 (e-PCR), detects polymorphism
- UniSTS:527198

AI852361 (e-PCR)
- UniSTS:165993

AW259676 (e-PCR)
- UniSTS:178428

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in proximal dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GRB10-interacting GYF protein 2

Names: PERQ amino acid-rich with GYF domain-containing protein 2; trinucleotide repeat containing 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110212.2 → NP_001103682.1 GRB10-interacting GYF protein 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.

Source sequence(s)

AC157811, AC158961, AK079246, AK122337

Consensus CDS

CCDS56636.1

UniProtKB/TrEMBL

G3UWR2, G3UYG6

Related

ENSMUSP00000134077.2, ENSMUST00000172794.8

Conserved Domains (2) summary

PTZ00449
Location:324 → 468

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:528 → 583

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
NM_146112.4 → NP_666224.3 GRB10-interacting GYF protein 2 isoform a

See identical proteins and their annotated locations for NP_666224.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AC157811, BC089036, BY117987

Consensus CDS

CCDS15133.1

UniProtKB/Swiss-Prot

Q0VGQ7, Q3UNS2, Q63ZU9, Q6Y7W8, Q80TV1, Q8K0R0, Q8R0A3

UniProtKB/TrEMBL

G3UWR2

Related

ENSMUSP00000027475.9, ENSMUST00000027475.15

Conserved Domains (2) summary

PTZ00449
Location:330 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:534 → 589

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

87254653..87378532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320347.2 → XP_017175836.1 GRB10-interacting GYF protein 2 isoform X3

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PTZ00449
Location:330 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:534 → 589

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529466.2 → XP_006529529.1 GRB10-interacting GYF protein 2 isoform X2

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PHA03307
Location:292 → 486

PHA03307; transcriptional regulator ICP4; Provisional

cd00072
Location:533 → 588

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529467.2 → XP_006529530.1 GRB10-interacting GYF protein 2 isoform X5

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PHA03307
Location:286 → 480

PHA03307; transcriptional regulator ICP4; Provisional

cd00072
Location:527 → 582

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529468.2 → XP_006529531.1 GRB10-interacting GYF protein 2 isoform X6

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PTZ00449
Location:279 → 423

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:483 → 538

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529469.2 → XP_006529532.1 GRB10-interacting GYF protein 2 isoform X7

See identical proteins and their annotated locations for XP_006529532.1

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PTZ00449
Location:273 → 417

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:477 → 532

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529464.4 → XP_006529527.1 GRB10-interacting GYF protein 2 isoform X1

See identical proteins and their annotated locations for XP_006529527.1

UniProtKB/Swiss-Prot

Q0VGQ7, Q3UNS2, Q63ZU9, Q6Y7W8, Q80TV1, Q8K0R0, Q8R0A3

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PTZ00449
Location:330 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:534 → 589

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_036164496.1 → XP_036020389.1 GRB10-interacting GYF protein 2 isoform X4

UniProtKB/TrEMBL

G3UWR2, G3UYG6

Conserved Domains (2) summary

PTZ00449
Location:324 → 468

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:528 → 583

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_036164500.1 → XP_036020393.1 GRB10-interacting GYF protein 2 isoform X4

UniProtKB/TrEMBL

G3UWR2, G3UYG6

Conserved Domains (2) summary

PTZ00449
Location:324 → 468

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:528 → 583

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529465.5 → XP_006529528.1 GRB10-interacting GYF protein 2 isoform X1

See identical proteins and their annotated locations for XP_006529528.1

UniProtKB/Swiss-Prot

Q0VGQ7, Q3UNS2, Q63ZU9, Q6Y7W8, Q80TV1, Q8K0R0, Q8R0A3

UniProtKB/TrEMBL

G3UWR2

Related

ENSMUSP00000133327.2, ENSMUST00000174501.8

Conserved Domains (2) summary

PTZ00449
Location:330 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:534 → 589

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006529470.5 → XP_006529533.1 GRB10-interacting GYF protein 2 isoform X8

UniProtKB/TrEMBL

G3UWR2

Conserved Domains (2) summary

PTZ00449
Location:176 → 320

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd00072
Location:380 → 435

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.