U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta [ Mus musculus (house mouse) ]

    Gene ID: 140781, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myh7provided by MGI
    Official Full Name
    myosin, heavy polypeptide 7, cardiac muscle, betaprovided by MGI
    Primary source
    MGI:MGI:2155600
    See related
    Ensembl:ENSMUSG00000053093 AllianceGenome:MGI:2155600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B-MHC; Myhcb; MyHC-I; Myhc-b; betaMHC; beta-MHC; myHC-beta; myHC-slow; MYH-beta/slow
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and actin filament binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and transition between fast and slow fiber. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including diaphragm; eye; heart; musculature; and somite. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward heart adult (RPKM 264.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myh7 in Genome Data Viewer
    Location:
    14 C3; 14 28.01 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55208141..55232083, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54970684..54994626, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 6, cardiac muscle, alpha Neighboring gene microRNA 208a Neighboring gene predicted gene, 52092 Neighboring gene myosin heavy chain associated RNA transcript Neighboring gene microRNA 208b Neighboring gene predicted gene, 31251 Neighboring gene STARR-seq mESC enhancer starr_36751 Neighboring gene VISTA enhancer mm771 Neighboring gene VISTA enhancer mm1288 Neighboring gene STARR-positive B cell enhancer ABC_E7316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55633922-55634031 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:55634351-55634460 Neighboring gene neuroguidin, EIF4E binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle filament sliding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle filament sliding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of slow-twitch skeletal muscle fiber contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of slow-twitch skeletal muscle fiber contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of the force of skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in myosin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myosin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin-7
    Names
    myosin heavy chain 7
    myosin heavy chain, cardiac muscle, fetal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361607.1NP_001348536.1  myosin-7

      Status: VALIDATED

      Source sequence(s)
      CT025533
      Consensus CDS
      CCDS27106.1
      UniProtKB/Swiss-Prot
      Q3TGM2, Q3TZN2, Q91Z83
      UniProtKB/TrEMBL
      B2RXX9, B2RY26
      Related
      ENSMUSP00000126840.2, ENSMUST00000168485.8
      Conserved Domains (3) summary
      COG5022
      Location:371432
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:11731930
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain
    2. NM_001425737.1NP_001412666.1  myosin-7

      Status: VALIDATED

      Source sequence(s)
      CT025533
      UniProtKB/Swiss-Prot
      Q3TGM2, Q3TZN2, Q91Z83
      UniProtKB/TrEMBL
      B2RXX9, B2RY26
    3. NM_080728.3NP_542766.1  myosin-7

      See identical proteins and their annotated locations for NP_542766.1

      Status: VALIDATED

      Source sequence(s)
      CT025533
      Consensus CDS
      CCDS27106.1
      UniProtKB/Swiss-Prot
      Q3TGM2, Q3TZN2, Q91Z83
      UniProtKB/TrEMBL
      B2RXX9, B2RY26
      Related
      ENSMUSP00000099867.4, ENSMUST00000102803.11
      Conserved Domains (3) summary
      COG5022
      Location:371432
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:11731930
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55208141..55232083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158456.1XP_036014349.1  myosin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TGM2, Q3TZN2, Q91Z83
      UniProtKB/TrEMBL
      B2RXX9, B2RY26
      Conserved Domains (3) summary
      COG5022
      Location:371432
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:11731930
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain
    2. XM_017315841.3XP_017171330.1  myosin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3TGM2, Q3TZN2, Q91Z83
      UniProtKB/TrEMBL
      B2RXX9, B2RY26
      Conserved Domains (3) summary
      COG5022
      Location:371432
      COG5022; Myosin heavy chain [General function prediction only]
      TIGR02168
      Location:11731930
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01377
      Location:99766
      MYSc_class_II; class II myosins, motor domain