Pum2 pumilio RNA-binding family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pum2provided by MGI
Official Full Name: pumilio RNA-binding family member 2provided by MGI
Primary source: MGI:MGI:1931751
See related: Ensembl:ENSMUSG00000020594 AllianceGenome:MGI:1931751
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pumm2; 5730503J23Rik
Summary: Enables lncRNA binding activity and pumilio-response element binding activity. Involved in several processes, including adipose tissue development; hair follicle development; and respiratory electron transport chain. Acts upstream of or within post-transcriptional regulation of gene expression and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 23.4), whole brain E14.5 (RPKM 23.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 3.92 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (8724092..8802583)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (8674092..8752583)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.
Title: PUM2 promoted osteoarthritis progression through PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation.
Norad Competently Binds with Pum2 to Regulate Neuronal Apoptosis and Play a Neuroprotective Role After SAH in Mice.
Title: Norad Competently Binds with Pum2 to Regulate Neuronal Apoptosis and Play a Neuroprotective Role After SAH in Mice.
Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
Title: Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
PUM2 regulates the formation of thoracic aortic dissection through EFEMP1.
Title: PUM2 regulates the formation of thoracic aortic dissection through EFEMP1.
PUM2 aggravates the neuroinflammation and brain damage induced by ischemia-reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1.
Title: PUM2 aggravates the neuroinflammation and brain damage induced by ischemia-reperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1.
Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.
Title: Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.
PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.
Title: PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.
Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex.
Title: Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex.
Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Title: Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Pumilio2 Promotes Growth of Mature Neurons.
Title: Pumilio2 Promotes Growth of Mature Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pum2 (e-PCR), detects polymorphism
- UniSTS:479021

D6Got27 (e-PCR)
- UniSTS:113642

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pumilio-response element binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adipose tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in hair follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting of injured axon	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting of injured axon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular mRNA localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stress granule assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pumilio homolog 2

Names: pumilio 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160219.1 → NP_001153691.1 pumilio homolog 2 isoform 1

See identical proteins and their annotated locations for NP_001153691.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK147617, AY027917, BQ828592, CJ124920

Consensus CDS

CCDS25802.1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Related

ENSMUSP00000131074.2, ENSMUST00000163569.8

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
NM_001160220.1 → NP_001153692.1 pumilio homolog 2 isoform 2

See identical proteins and their annotated locations for NP_001153692.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in an isoform (2) lacking 2 aa compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

AK141682, AK147617, BQ828592, CJ124920

Consensus CDS

CCDS49025.1

UniProtKB/TrEMBL

Q3UR91

Related

ENSMUSP00000106751.3, ENSMUST00000111122.9

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain
NM_001160221.1 → NP_001153693.1 pumilio homolog 2 isoform 2

See identical proteins and their annotated locations for NP_001153693.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in an isoform (2) lacking 2 aa compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

AK134185, AK141682, AK147617, BQ828592

Consensus CDS

CCDS49025.1

UniProtKB/TrEMBL

Q3UR91

Related

ENSMUSP00000106752.3, ENSMUST00000111123.9

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain
NM_001160222.1 → NP_001153694.1 pumilio homolog 2 isoform 3

See identical proteins and their annotated locations for NP_001153694.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, is missing an in-frame coding exon, and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.

Source sequence(s)

AK134185, AK147617, AK163964, BQ828592

Consensus CDS

CCDS49026.1

UniProtKB/Swiss-Prot

Q80U58

UniProtKB/TrEMBL

Q3TQ29

Related

ENSMUSP00000137020.2, ENSMUST00000178015.8

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001310519.1 → NP_001297448.1 pumilio homolog 2 isoform 4

See identical proteins and their annotated locations for NP_001297448.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, uses two alternate in-frame splice sites in the coding region, and is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (4) compared to isoform 1.

Source sequence(s)

AK134185, AK147617, AK163964, BQ828592

Consensus CDS

CCDS79105.1

UniProtKB/TrEMBL

Q3TQ29

Related

ENSMUSP00000020915.4, ENSMUST00000020915.10

Conserved Domains (1) summary

cd07920
Location:637 → 958

Pumilio; Pumilio-family RNA binding domain
NM_030723.2 → NP_109648.2 pumilio homolog 2 isoform 1

See identical proteins and their annotated locations for NP_109648.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC134245, AF315590, AK147617, AY027917, BQ828592

Consensus CDS

CCDS25802.1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Related

ENSMUSP00000128292.2, ENSMUST00000168361.8

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain

RNA

NR_027670.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) has multiple differences compared to variant 1, but the presence of two additional exons in the 5' coding region causes a frame-shift. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK122225, AK147617, BQ828592, CJ124920

Related

ENSMUST00000165293.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

8724092..8802583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515279.4 → XP_006515342.1 pumilio homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006515342.1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
XM_006515284.4 → XP_006515347.1 pumilio homolog 2 isoform X10

Conserved Domains (1) summary

cd07920
Location:642 → 965

Pumilio; Pumilio-family RNA binding domain
XM_006515285.4 → XP_006515348.1 pumilio homolog 2 isoform X11

See identical proteins and their annotated locations for XP_006515348.1

UniProtKB/Swiss-Prot

Q80U58

Related

ENSMUSP00000132122.2, ENSMUST00000169089.8

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
XM_006515280.4 → XP_006515343.1 pumilio homolog 2 isoform X3

Conserved Domains (1) summary

cd07920
Location:716 → 1039

Pumilio; Pumilio-family RNA binding domain
XM_017315255.2 → XP_017170744.1 pumilio homolog 2 isoform X5

Conserved Domains (1) summary

cd07920
Location:716 → 1037

Pumilio; Pumilio-family RNA binding domain
XM_017315258.2 → XP_017170747.1 pumilio homolog 2 isoform X13

UniProtKB/TrEMBL

Q3TQ29

Conserved Domains (1) summary

cd07920
Location:637 → 958

Pumilio; Pumilio-family RNA binding domain
XM_017315254.2 → XP_017170743.1 pumilio homolog 2 isoform X4

Conserved Domains (1) summary

cd07920
Location:715 → 1038

Pumilio; Pumilio-family RNA binding domain
XM_017315256.2 → XP_017170745.1 pumilio homolog 2 isoform X6

Conserved Domains (1) summary

cd07920
Location:715 → 1036

Pumilio; Pumilio-family RNA binding domain
XM_030246997.1 → XP_030102857.1 pumilio homolog 2 isoform X12

Conserved Domains (1) summary

cd07920
Location:636 → 959

Pumilio; Pumilio-family RNA binding domain
XM_017315259.2 → XP_017170748.1 pumilio homolog 2 isoform X14

Conserved Domains (1) summary

cd07920
Location:636 → 957

Pumilio; Pumilio-family RNA binding domain
XM_036157686.1 → XP_036013579.1 pumilio homolog 2 isoform X21
XM_030247001.1 → XP_030102861.1 pumilio homolog 2 isoform X17

Conserved Domains (1) summary

cd07920
Location:581 → 902

Pumilio; Pumilio-family RNA binding domain
XM_030247000.2 → XP_030102860.1 pumilio homolog 2 isoform X15

Conserved Domains (1) summary

cd07920
Location:586 → 907

Pumilio; Pumilio-family RNA binding domain
XM_036157687.1 → XP_036013580.1 pumilio homolog 2 isoform X22
XM_017315257.3 → XP_017170746.1 pumilio homolog 2 isoform X9

Conserved Domains (1) summary

cd07920
Location:665 → 986

Pumilio; Pumilio-family RNA binding domain
XM_030246995.2 → XP_030102855.1 pumilio homolog 2 isoform X9

Conserved Domains (1) summary

cd07920
Location:665 → 986

Pumilio; Pumilio-family RNA binding domain
XM_036157684.1 → XP_036013577.1 pumilio homolog 2 isoform X20

Conserved Domains (1) summary

cd07920
Location:417 → 738

Pumilio; Pumilio-family RNA binding domain
XM_030246999.2 → XP_030102859.1 pumilio homolog 2 isoform X16

Conserved Domains (1) summary

cd07920
Location:586 → 909

Pumilio; Pumilio-family RNA binding domain
XM_006515283.5 → XP_006515346.1 pumilio homolog 2 isoform X7

See identical proteins and their annotated locations for XP_006515346.1

Conserved Domains (1) summary

cd07920
Location:665 → 988

Pumilio; Pumilio-family RNA binding domain
XM_030246994.2 → XP_030102854.1 pumilio homolog 2 isoform X8

Conserved Domains (1) summary

cd07920
Location:660 → 983

Pumilio; Pumilio-family RNA binding domain
XM_006515282.5 → XP_006515345.1 pumilio homolog 2 isoform X7

See identical proteins and their annotated locations for XP_006515345.1

Conserved Domains (1) summary

cd07920
Location:665 → 988

Pumilio; Pumilio-family RNA binding domain
XM_030247003.2 → XP_030102863.1 pumilio homolog 2 isoform X17

Conserved Domains (1) summary

cd07920
Location:581 → 902

Pumilio; Pumilio-family RNA binding domain
XM_036157682.1 → XP_036013575.1 pumilio homolog 2 isoform X19

Conserved Domains (1) summary

cd07920
Location:496 → 819

Pumilio; Pumilio-family RNA binding domain
XM_030247002.2 → XP_030102862.1 pumilio homolog 2 isoform X18

Conserved Domains (1) summary

cd07920
Location:580 → 903

Pumilio; Pumilio-family RNA binding domain
XM_036157685.1 → XP_036013578.1 pumilio homolog 2 isoform X20

Conserved Domains (1) summary

cd07920
Location:417 → 738

Pumilio; Pumilio-family RNA binding domain
XM_036157683.1 → XP_036013576.1 pumilio homolog 2 isoform X19

Conserved Domains (1) summary

cd07920
Location:496 → 819

Pumilio; Pumilio-family RNA binding domain
XM_006515277.2 → XP_006515340.1 pumilio homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006515340.1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
XM_006515278.5 → XP_006515341.1 pumilio homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006515341.1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
XM_036157681.1 → XP_036013574.1 pumilio homolog 2 isoform X13

UniProtKB/TrEMBL

Q3TQ29

Conserved Domains (1) summary

cd07920
Location:637 → 958

Pumilio; Pumilio-family RNA binding domain
XM_030246996.1 → XP_030102856.1 pumilio homolog 2 isoform X11

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
XM_030246993.2 → XP_030102853.1 pumilio homolog 2 isoform X1

UniProtKB/Swiss-Prot

Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
XM_036157680.1 → XP_036013573.1 pumilio homolog 2 isoform X2

UniProtKB/TrEMBL

Q3UR91

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain