Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc1a2provided by MGI
Official Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2provided by MGI
Primary source: MGI:MGI:101931
See related: Ensembl:ENSMUSG00000005089 AllianceGenome:MGI:101931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik
Summary: Enables cysteine transmembrane transporter activity; high-affinity L-glutamate transmembrane transporter activity; and monoatomic anion transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; monoatomic anion transmembrane transport; and positive regulation of D-glucose import. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 172.0), frontal lobe adult (RPKM 137.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.13 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (102488584..102621129)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (102658239..102790784)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome.
Title: Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome.
Yes-associated protein regulates glutamate homeostasis through promoting the expression of excitatory amino acid transporter-2 in astrocytes via beta-catenin signaling.
Title: Yes-associated protein regulates glutamate homeostasis through promoting the expression of excitatory amino acid transporter-2 in astrocytes via β-catenin signaling.
Astrocytic aryl hydrocarbon receptor mediates chronic kidney disease-associated mental disorders involving GLT1 hypofunction and neuronal activity enhancement in the mouse brain.
Title: Astrocytic aryl hydrocarbon receptor mediates chronic kidney disease-associated mental disorders involving GLT1 hypofunction and neuronal activity enhancement in the mouse brain.
Functional investigation of SLC1A2 variants associated with epilepsy.
Title: Functional investigation of SLC1A2 variants associated with epilepsy.
Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
Title: Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats.
Title: Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats.
Amygdalar kappa-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Title: Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy.
Title: Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy.
Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder.
Title: Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder.
Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors.
Title: Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI159670 (e-PCR)
- UniSTS:158991

Slc1a2 (e-PCR), detects polymorphism
- UniSTS:144416

Slc1a2 (e-PCR), detects polymorphism
- UniSTS:465496

D43796 (e-PCR)
- UniSTS:124833

Slc1a2 (e-PCR), detects polymorphism
- UniSTS:547014

AB007810 (e-PCR)
- UniSTS:178660

RH138571 (e-PCR)
- UniSTS:220658

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cysteine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables high-affinity L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cocaine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cysteine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter reuptake	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter reuptake	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to amino acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of membrane protein complex	IEA Inferred from Electronic Annotation more info
part_of membrane protein complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IGI Inferred from Genetic Interaction more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: excitatory amino acid transporter 2

Names: EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; glutamate transporter 1c; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077514.4 → NP_001070982.1 excitatory amino acid transporter 2 isoform 1

See identical proteins and their annotated locations for NP_001070982.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK134609, AL844155

Consensus CDS

CCDS38188.1

UniProtKB/Swiss-Prot

O35877, O54686, O54687, P43006

UniProtKB/TrEMBL

Q3USU5, Q3UYK6

Related

ENSMUSP00000079100.4, ENSMUST00000080210.10

Conserved Domains (1) summary

pfam00375
Location:46 → 495

SDF; Sodium:dicarboxylate symporter family
NM_001077515.2 → NP_001070983.1 excitatory amino acid transporter 2 isoform 2

See identical proteins and their annotated locations for NP_001070983.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK134609, AL844155, AL844605

Consensus CDS

CCDS38189.1

UniProtKB/TrEMBL

A2APL8, Q3USU5

Related

ENSMUSP00000106843.2, ENSMUST00000111212.8

Conserved Domains (1) summary

pfam00375
Location:43 → 492

SDF; Sodium:dicarboxylate symporter family
NM_001361018.1 → NP_001347947.1 excitatory amino acid transporter 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL844155, AL844605

Consensus CDS

CCDS89527.1

UniProtKB/TrEMBL

A2APL5, X2D841

Related

ENSMUSP00000106844.2, ENSMUST00000111213.8

Conserved Domains (1) summary

pfam00375
Location:46 → 495

SDF; Sodium:dicarboxylate symporter family
NM_011393.2 → NP_035523.1 excitatory amino acid transporter 2 isoform 3

See identical proteins and their annotated locations for NP_035523.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AL844155, AL844605

Consensus CDS

CCDS16469.1

UniProtKB/TrEMBL

A2APL7, X2D841

Related

ENSMUSP00000005220.5, ENSMUST00000005220.11

Conserved Domains (1) summary

pfam00375
Location:43 → 492

SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

102488584..102621129

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248894.1 → XP_030104754.1 excitatory amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

Q3USU5

Conserved Domains (1) summary

pfam00375
Location:37 → 486

SDF; Sodium:dicarboxylate symporter family
XM_006499047.4 → XP_006499110.1 excitatory amino acid transporter 2 isoform X2

UniProtKB/TrEMBL

X2D841

Conserved Domains (1) summary

pfam00375
Location:46 → 495

SDF; Sodium:dicarboxylate symporter family
XM_011239398.4 → XP_011237700.1 excitatory amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

Q3USU5

Conserved Domains (1) summary

pfam00375
Location:37 → 486

SDF; Sodium:dicarboxylate symporter family
XM_030248893.1 → XP_030104753.1 excitatory amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

Q3USU5

Conserved Domains (1) summary

pfam00375
Location:37 → 486

SDF; Sodium:dicarboxylate symporter family