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    Spata13 spermatogenesis associated 13 [ Mus musculus (house mouse) ]

    Gene ID: 219140, updated on 3-Dec-2024

    Summary

    Official Symbol
    Spata13provided by MGI
    Official Full Name
    spermatogenesis associated 13provided by MGI
    Primary source
    MGI:MGI:104838
    See related
    Ensembl:ENSMUSG00000021990 AllianceGenome:MGI:104838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    asef2; ESTM11; mFLJ00298
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in podosome. Is expressed in brain; liver; testis; thymus primordium; and vertebral cartilage condensation. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.9), adrenal adult (RPKM 5.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Spata13 in Genome Data Viewer
    Location:
    14 D1; 14 31.77 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60722617..61002005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60485168..60764556)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 2 Neighboring gene peptidylprolyl isomerase A pseudogene 14_696.1 Neighboring gene STARR-positive B cell enhancer ABC_E11785 Neighboring gene VISTA enhancer mm1122 Neighboring gene STARR-positive B cell enhancer ABC_E11571 Neighboring gene predicted gene, 41166 Neighboring gene STARR-seq mESC enhancer starr_36860 Neighboring gene predicted gene, 41165 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61328022-61328292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61351140-61351293 Neighboring gene STARR-seq mESC enhancer starr_36862 Neighboring gene STARR-positive B cell enhancer mm9_chr14:61357423-61357724 Neighboring gene STARR-seq mESC enhancer starr_36864 Neighboring gene predicted gene, 34997 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00298

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    spermatogenesis-associated protein 13
    Names
    APC-stimulated guanine nucleotide exchange factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033272.3NP_001028444.1  spermatogenesis-associated protein 13 isoform 1

      See identical proteins and their annotated locations for NP_001028444.1

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      Consensus CDS
      CCDS49516.1
      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Related
      ENSMUSP00000022566.8, ENSMUST00000022566.14
      Conserved Domains (4) summary
      cd11973
      Location:726797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8361015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10201158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    2. NM_001310594.2NP_001297523.1  spermatogenesis-associated protein 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      Consensus CDS
      CCDS79328.1
      UniProtKB/Swiss-Prot
      Q3TZ09, Q5DU57
      UniProtKB/TrEMBL
      B7ZNJ6, E0CYU0
      Related
      ENSMUSP00000123888.2, ENSMUST00000162945.2
      Conserved Domains (4) summary
      cd11973
      Location:56127
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:350488
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:378477
      PH; PH domain
      pfam00621
      Location:166345
      RhoGEF; RhoGEF domain
    3. NM_001404949.1NP_001391878.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835, AC164429
      UniProtKB/TrEMBL
      B9EHV2
    4. NM_001404950.1NP_001391879.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/TrEMBL
      B9EHV2
    5. NM_001404951.1NP_001391880.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/TrEMBL
      B9EHV2
    6. NM_001404952.1NP_001391881.1  spermatogenesis-associated protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/TrEMBL
      B9EHV2
    7. NM_001404953.1NP_001391882.1  spermatogenesis-associated protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/Swiss-Prot
      Q3TZ09, Q5DU57
      UniProtKB/TrEMBL
      B7ZNJ6
    8. NM_001404954.1NP_001391883.1  spermatogenesis-associated protein 13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
    9. NM_001404964.1NP_001391893.1  spermatogenesis-associated protein 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Related
      ENSMUSP00000123928.2, ENSMUST00000160973.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      60722617..61002005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247763.1XP_030103623.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8361015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10201158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    2. XM_017315974.3XP_017171463.1  spermatogenesis-associated protein 13 isoform X8

      Conserved Domains (1) summary
      PHA03247
      Location:251497
      PHA03247; large tegument protein UL36; Provisional
    3. XM_036158561.1XP_036014454.1  spermatogenesis-associated protein 13 isoform X1

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:777848
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8871066
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251497
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10711209
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    4. XM_036158562.1XP_036014455.1  spermatogenesis-associated protein 13 isoform X2

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:767838
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8771056
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251500
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10611199
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    5. XM_036158565.1XP_036014458.1  spermatogenesis-associated protein 13 isoform X5

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:655726
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:765944
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251603
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:9491087
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    6. XM_011245026.3XP_011243328.1  spermatogenesis-associated protein 13 isoform X3

      See identical proteins and their annotated locations for XP_011243328.1

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8361015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10201158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    7. XM_030247762.1XP_030103622.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8361015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10201158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    8. XM_030247764.1XP_030103624.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:8361015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:10201158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    9. XM_006518870.3XP_006518933.1  spermatogenesis-associated protein 13 isoform X7

      UniProtKB/Swiss-Prot
      Q3TZ09, Q5DU57
      Conserved Domains (3) summary
      cd11973
      Location:231302
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:341520
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:525663
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain