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    Srrm2 serine/arginine repetitive matrix 2 [ Mus musculus (house mouse) ]

    Gene ID: 75956, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Srrm2provided by MGI
    Official Full Name
    serine/arginine repetitive matrix 2provided by MGI
    Primary source
    MGI:MGI:1923206
    See related
    Ensembl:ENSMUSG00000039218 AllianceGenome:MGI:1923206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRm300; mKIAA0324; 5033413A03Rik
    Summary
    Predicted to enable C2H2 zinc finger domain binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 122.5), ovary adult (RPKM 102.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srrm2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.07 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24009501..24043715)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23790527..23824741)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E4197 Neighboring gene FLYWCH family member 2 Neighboring gene predicted gene, 52285 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene microRNA 5125 Neighboring gene elongin B Neighboring gene serine protease 33 Neighboring gene serine protease 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SRRM2 splicing factor modulates cell fate in early development. Carvalho S, et al. Biol Open, 2024 Apr 15. PMID 38656788, Free PMC Article
    2. A coactivator of pre-mRNA splicing. Blencowe BJ, et al. Genes Dev, 1998 Apr 1. PMID 9531537, Free PMC Article
    3. RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway. Feng Z, et al. Oncogene, 2023 Jun. PMID 37142680
    4. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
    5. SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Hasegawa K, et al. Dev Cell, 2015 Mar 9. PMID 25703348, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRRM2 splicing factor modulates cell fate in early development.
      Title: SRRM2 splicing factor modulates cell fate in early development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368687.1 → NP_001355616.1  serine/arginine repetitive matrix protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122821
      Consensus CDS
      CCDS89004.1
      UniProtKB/Swiss-Prot
      E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
      Related
      ENSMUSP00000139842.2, ENSMUST00000190686.7
      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    2. NM_175229.3 → NP_780438.2  serine/arginine repetitive matrix protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122821, AI463539, AK017163, AK090123, AK122248, BQ033752, BY202609, CJ178299
      Consensus CDS
      CCDS37475.1
      UniProtKB/Swiss-Prot
      Q8BTI8
      Related
      ENSMUSP00000085993.5, ENSMUST00000088621.11
      Conserved Domains (1) summary
      pfam02956
      Location:473 → 513
      TT_ORF1; TT viral orf 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24009501..24043715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250131.2 → XP_030105991.1  serine/arginine repetitive matrix protein 2 isoform X6

      Conserved Domains (1) summary
      cl40451
      Location:39 → 102
      cwf21; cwf21 domain

    2. XM_036160825.1 → XP_036016718.1  serine/arginine repetitive matrix protein 2 isoform X6

      Conserved Domains (1) summary
      cl40451
      Location:39 → 102
      cwf21; cwf21 domain

    3. XM_006525077.5 → XP_006525140.1  serine/arginine repetitive matrix protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006525140.1

      UniProtKB/Swiss-Prot
      E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    4. XM_017317709.2 → XP_017173198.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    5. XM_036160822.1 → XP_036016715.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    6. XM_006525079.4 → XP_006525142.1  serine/arginine repetitive matrix protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006525142.1

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    7. XM_017317713.2 → XP_017173202.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    8. XM_017317712.2 → XP_017173201.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    9. XM_030250130.1 → XP_030105990.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    10. XM_017317710.2 → XP_017173199.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    11. XM_017317711.2 → XP_017173200.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    12. XM_017317714.2 → XP_017173203.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    13. XM_036160823.1 → XP_036016716.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    14. XM_030250129.1 → XP_030105989.1  serine/arginine repetitive matrix protein 2 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    15. XM_011246701.3 → XP_011245003.1  serine/arginine repetitive matrix protein 2 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    16. XM_017317708.2 → XP_017173197.1  serine/arginine repetitive matrix protein 2 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    17. XM_011246702.3 → XP_011245004.1  serine/arginine repetitive matrix protein 2 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    18. XM_006525078.4 → XP_006525141.1  serine/arginine repetitive matrix protein 2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain

    19. XM_011246704.4 → XP_011245006.1  serine/arginine repetitive matrix protein 2 isoform X6

      See identical proteins and their annotated locations for XP_011245006.1

      Conserved Domains (1) summary
      cl40451
      Location:39 → 102
      cwf21; cwf21 domain

    20. XM_036160824.1 → XP_036016717.1  serine/arginine repetitive matrix protein 2 isoform X6

      Conserved Domains (1) summary
      cl40451
      Location:39 → 102
      cwf21; cwf21 domain

    21. XM_030250133.2 → XP_030105993.1  serine/arginine repetitive matrix protein 2 isoform X7

    22. XM_030250132.2 → XP_030105992.1  serine/arginine repetitive matrix protein 2 isoform X6

      Conserved Domains (1) summary
      cl40451
      Location:39 → 102
      cwf21; cwf21 domain

    23. XM_030250128.2 → XP_030105988.1  serine/arginine repetitive matrix protein 2 isoform X1

      UniProtKB/Swiss-Prot
      E9QNB0, Q3TBY5, Q569P9, Q80U37, Q8BTI8, Q8K383
      Conserved Domains (3) summary
      PHA03247
      Location:1982 → 2466
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:309 → 686
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08312
      Location:59 → 101
      cwf21; cwf21 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTI8.3 GenPept UniProtKB/Swiss-Prot:Q8BTI8

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