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    Thtpa thiamine triphosphatase [ Mus musculus (house mouse) ]

    Gene ID: 105663, updated on 27-Nov-2024

    Summary

    Official Symbol
    Thtpaprovided by MGI
    Official Full Name
    thiamine triphosphataseprovided by MGI
    Primary source
    MGI:MGI:2446078
    See related
    Ensembl:ENSMUSG00000045691 AllianceGenome:MGI:2446078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a cytosolic enzyme that catalyzes the conversion of thiamine triphosphate to thiamine diphosphate. The encoded protein requires divalent cations for enzymatic activity. The gene product is believed to play a role in regulation of thiamine triphosphate intracellular concentration, and it may be a messenger in cell signaling in response to cellular stress. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.0), CNS E14 (RPKM 7.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Thtpa in Genome Data Viewer
    Location:
    14 C3; 14 28.07 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55332241..55336452)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55094784..55098995)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36756 Neighboring gene zinc finger homeobox 2 Neighboring gene zinc finger homeobox 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36762 Neighboring gene STARR-positive B cell enhancer ABC_E11569 Neighboring gene STARR-positive B cell enhancer ABC_E9405 Neighboring gene adaptor protein complex AP-1, gamma 2 subunit Neighboring gene junctophilin 4 Neighboring gene predicted gene, 53860

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC38198

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiamine triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiamine triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiamine triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine triphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thiamine diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thiamine diphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thiamine diphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thiamine-triphosphatase
    Names
    ThTPase
    NP_694723.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153083.5NP_694723.1  thiamine-triphosphatase

      See identical proteins and their annotated locations for NP_694723.1

      Status: REVIEWED

      Source sequence(s)
      AC157212
      Consensus CDS
      CCDS27108.1
      UniProtKB/Swiss-Prot
      Q3V1G2, Q8C3P9, Q8JZL3
      Related
      ENSMUSP00000056026.8, ENSMUST00000050575.9
      Conserved Domains (1) summary
      cd07758
      Location:6198
      ThTPase; Thiamine Triphosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55332241..55336452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)