U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gast gastrin [ Mus musculus (house mouse) ]

    Gene ID: 14459, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gastprovided by MGI
    Official Full Name
    gastrinprovided by MGI
    Primary source
    MGI:MGI:104768
    See related
    Ensembl:ENSMUSG00000017165 AllianceGenome:MGI:104768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAS
    Summary
    This gene encodes the peptide hormone gastrin, which stimulates gastric acid secretion, proliferation, cell migration and angiogenesis, as well as inhibits apoptosis. The encoded preproprotein undergoes proteolytic processing to generate multiple gastrin peptides differing in size. Mice lacking the encoded protein exhibit a decrease in the number of parietal cells, achlorohydria and a decrease in the colonic proliferation. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward stomach adult (RPKM 365.6) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gast in Genome Data Viewer
    Location:
    11 D; 11 63.46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100225233..100227823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100334407..100336997)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206 Neighboring gene STARR-seq mESC enhancer starr_30725 Neighboring gene STARR-positive B cell enhancer ABC_E1148 Neighboring gene STARR-positive B cell enhancer ABC_E3019 Neighboring gene STARR-positive B cell enhancer ABC_E11493 Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene huntingtin-associated protein 1 Neighboring gene predicted pseudogene 10039

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Interferon gamma induction of gastric mucous neck cell hypertrophy. Kang W, et al. Lab Invest, 2005 May. PMID 15765119
    2. Regulation of parietal cell migration by gastrin in the mouse. Kirton CM, et al. Am J Physiol Gastrointest Liver Physiol, 2002 Sep. PMID 12181195
    3. Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice. Hinkle KL, et al. Am J Physiol Gastrointest Liver Physiol, 2003 Jan. PMID 12388185
    4. Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene. Boushey RP, et al. Gastroenterology, 2003 Oct. PMID 14517799
    5. Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice. Zhao CM, et al. Regul Pept, 2003 Oct 15. PMID 14556957

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
      Title: Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis.
    2. Gastrin induces nuclear export and proteasome degradation of menin in duodenal glial cells.
      Title: Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
    3. PTHLH is a gastrin-regulated growth factor that might contribute to gastric epithelial cell homeostasis.
      Title: Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.
    4. Renal-selective silencing of Gast by the renal subcapsular injection of Gast siRNA in BALB/c mice decreases renal dopamine production and increases blood pressure.
      Title: Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA.
    5. Gastrin is expressed in insulin secreting cells of adult diabetic mice.
      Title: Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.
    6. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells.
      Title: Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
    7. increased circulating concentrations of progastrin provide a physiological advantage against systemic hypoxia in mice
      Title: Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.
    8. Ihh signaling mediates gastrin-induced proliferation of epithelial cells in stomachs of adult mice.
      Title: Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.
    9. mouse corneal afferent sensory neurons expressed CCK and GAST, and the CCK1R receptors.
      Title: Expression of cholecystokinin, gastrin, and their receptors in the mouse cornea.
    10. Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia.
      Title: Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to food IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    gastrin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010257.4 → NP_034387.3  gastrin preproprotein

      Status: REVIEWED

      Source sequence(s)
      AK008494, AL590968
      Consensus CDS
      CCDS25418.1
      UniProtKB/Swiss-Prot
      P48757, P70334, Q64295, Q9CPR2
      UniProtKB/TrEMBL
      Q6GSF5
      Related
      ENSMUSP00000017309.2, ENSMUST00000017309.2
      Conserved Domains (1) summary
      pfam00918
      Location:87 → 99
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100225233..100227823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48757.2 GenPept UniProtKB/Swiss-Prot:P48757

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous