U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trpm8 transient receptor potential cation channel, subfamily M, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 171382, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trpm8provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 8provided by MGI
    Primary source
    MGI:MGI:2181435
    See related
    Ensembl:ENSMUSG00000036251 AllianceGenome:MGI:2181435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6
    Summary
    Enables calcium channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane and membrane raft. Is expressed in dorsal root ganglion; inferior vagus ganglion; lumbar dorsal root ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.5), CNS E18 (RPKM 0.2) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trpm8 in Genome Data Viewer
    Location:
    1 D; 1 44.57 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88234457..88318909)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88306735..88388853)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene secreted phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene predicted gene 28888

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2849

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ligand-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily M member 8
    Names
    TRP ion channel TRPM8
    long transient receptor potential channel 6
    transient receptor potential p8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134252.5NP_599013.1  transient receptor potential cation channel subfamily M member 8

      See identical proteins and their annotated locations for NP_599013.1

      Status: VALIDATED

      Source sequence(s)
      AC087780, AC102505, FQ976922
      Consensus CDS
      CCDS48316.1
      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Conserved Domains (2) summary
      TIGR00870
      Location:6571005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116386
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88234457..88318909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529226.2XP_006529289.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      See identical proteins and their annotated locations for XP_006529289.1

      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Related
      ENSMUSP00000036991.8, ENSMUST00000040210.14
      Conserved Domains (2) summary
      TIGR00870
      Location:6571005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116386
      LSDAT_euk; SLOG in TRPM
    2. XM_017319118.2XP_017174607.1  transient receptor potential cation channel subfamily M member 8 isoform X2

      Conserved Domains (1) summary
      cl39032
      Location:116386
      LSDAT_euk; SLOG in TRPM
    3. XM_006529225.2XP_006529288.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      See identical proteins and their annotated locations for XP_006529288.1

      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Related
      ENSMUSP00000131209.3, ENSMUST00000171176.3
      Conserved Domains (2) summary
      TIGR00870
      Location:6571005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116386
      LSDAT_euk; SLOG in TRPM
    4. XM_006529229.1XP_006529292.1  transient receptor potential cation channel subfamily M member 8 isoform X3

      Conserved Domains (1) summary
      TIGR00870
      Location:148496
      trp; transient-receptor-potential calcium channel protein