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    Ptgfrn prostaglandin F2 receptor negative regulator [ Mus musculus (house mouse) ]

    Gene ID: 19221, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ptgfrnprovided by MGI
    Official Full Name
    prostaglandin F2 receptor negative regulatorprovided by MGI
    Primary source
    MGI:MGI:1277114
    See related
    Ensembl:ENSMUSG00000027864 AllianceGenome:MGI:1277114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FPRP; EWI-F; CD9P-1; Trim45; 4833445A08Rik
    Summary
    Involved in myoblast fusion involved in skeletal muscle regeneration. Acts upstream of or within lipid droplet organization. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; glans of male genital tubercle; palatal shelf; skeleton; and submandibular gland primordium. Orthologous to human PTGFRN (prostaglandin F2 receptor inhibitor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 30.6), bladder adult (RPKM 17.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptgfrn in Genome Data Viewer
    Location:
    3 F2.2; 3 43.93 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100947546..101018061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101040230..101110745, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene CD101 antigen Neighboring gene STARR-seq mESC enhancer starr_08505 Neighboring gene STARR-seq mESC enhancer starr_08514 Neighboring gene STARR-seq mESC enhancer starr_08516 Neighboring gene STARR-seq mESC enhancer starr_08517 Neighboring gene STARR-seq mESC enhancer starr_08518 Neighboring gene nuclear import 7 pseudogene Neighboring gene tumor protein, translationally-controlled, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells. Weng L, et al. J Bone Miner Res, 2000 Jul. PMID 10893677
    2. The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. Charrin S, et al. J Biol Chem, 2009 Nov 13. PMID 19762465, Free PMC Article
    3. Cloning, sequencing and proposed structure for a prostaglandin F2 alpha receptor regulatory protein. Orlicky DJ, et al. Prostaglandins Leukot Essent Fatty Acids, 1996 Oct. PMID 8951995
    4. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. Orlicky DJ, et al. J Lipid Res, 1998 Jun. PMID 9643346
    5. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. Sala-Valdés M, et al. J Biol Chem, 2006 Jul 14. PMID 16690612

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins
      Title: EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin F2 receptor negative regulator
    Names
    CD9 partner 1
    glu-Trp-Ile EWI motif-containing protein F
    prostaglandin F2-alpha receptor regulatory protein
    prostaglandin F2-alpha receptor-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011197.3 → NP_035327.2  prostaglandin F2 receptor negative regulator precursor

      Status: VALIDATED

      Source sequence(s)
      AL645930, AL669872
      Consensus CDS
      CCDS17680.1
      UniProtKB/Swiss-Prot
      Q5SRA8, Q9WV91
      UniProtKB/TrEMBL
      Q69ZJ6
      Related
      ENSMUSP00000099755.4, ENSMUST00000102694.4
      Conserved Domains (3) summary
      smart00406
      Location:39 → 121
      IGv; Immunoglobulin V-Type
      smart00410
      Location:29 → 140
      IG_like; Immunoglobulin like
      cl11960
      Location:283 → 375
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100947546..101018061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319503.2 → XP_017174992.1  prostaglandin F2 receptor negative regulator isoform X1

      UniProtKB/TrEMBL
      Q69ZJ6
      Conserved Domains (2) summary
      smart00406
      Location:36 → 118
      IGv; Immunoglobulin V-Type
      smart00409
      Location:281 → 372
      IG; Immunoglobulin

    2. XM_006501147.4 → XP_006501210.1  prostaglandin F2 receptor negative regulator isoform X2

      UniProtKB/TrEMBL
      Q69ZJ6
      Conserved Domains (2) summary
      smart00406
      Location:27 → 109
      IGv; Immunoglobulin V-Type
      smart00409
      Location:272 → 363
      IG; Immunoglobulin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV91.2 GenPept UniProtKB/Swiss-Prot:Q9WV91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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