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    RNF167 ring finger protein 167 [ Homo sapiens (human) ]

    Gene ID: 26001, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RNF167provided by HGNC
    Official Full Name
    ring finger protein 167provided by HGNC
    Primary source
    HGNC:HGNC:24544
    See related
    Ensembl:ENSG00000108523 MIM:610431; AllianceGenome:HGNC:24544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LP2254; RING105; 5730408C10Rik
    Summary
    RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF167 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4940092..4945222)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4830440..4835570)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4843387..4848517)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11554 Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4841097-4841622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4841623-4842148 Neighboring gene solute carrier family 25 member 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4842149-4842674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11555 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4843813-4844007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4847507-4848050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8053 Neighboring gene profilin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8057 Neighboring gene enolase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4854946-4855680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing. Nair SV, et al. J Cell Sci, 2020 Jun 11. PMID 32409562
    2. RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking. Deshar R, et al. FEBS J, 2016 Dec. PMID 27808481
    3. Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. van Dijk JR, et al. Biochem J, 2014 Apr 1. PMID 24387786
    4. Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167. Ghilarducci K, et al. Int J Mol Sci, 2022 Jul 16. PMID 35887194, Free PMC Article
    5. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Lussier MP, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23129617, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
      Title: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
    2. Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
      Title: Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
    3. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
      Title: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
    4. Data indicate that E3 ubiquitin-protein ligase RNF167 ubiquitinates Arl8B at the lysine residue K141 and reduces the level of the ADP-ribosylation factor-like 8B Arl8B protein.
      Title: RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking.
    5. Point mutations are characterized in the RING domain of RNF167 and RNF13.
      Title: Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization.
    6. mutation of the Godzilla ubiquitylation target lysines on VAMP3 abrogates the formation of enlarged endosomes induced by either Godzilla or RNF167.
      Title: Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.
    7. RNF167 is a selective regulator of AMPAR-mediated neurotransmission.
      Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp566H073

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to leucine starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of lysosome localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysosome localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K29-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endolysosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF167
    Names
    RING-type E3 ubiquitin transferase RNF167
    NP_001307285.1
    NP_001307286.1
    NP_001307287.1
    NP_001307288.1
    NP_001307289.1
    NP_001307290.1
    NP_001307291.1
    NP_001307292.1
    NP_001307293.1
    NP_001307294.1
    NP_001357232.1
    NP_001357233.1
    NP_001357234.1
    NP_001357235.1
    NP_001357236.1
    NP_001357237.1
    NP_001357240.1
    NP_001357242.1
    NP_001362414.1
    NP_056343.1
    XP_047291686.1
    XP_054171650.1
    XP_054171651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320356.2 → NP_001307285.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Related
      ENSP00000459324.1, ENST00000571816.5
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    2. NM_001320357.2 → NP_001307286.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    3. NM_001320358.2 → NP_001307287.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    4. NM_001320359.2 → NP_001307288.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Related
      ENSP00000458794.1, ENST00000572430.5
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    5. NM_001320360.2 → NP_001307289.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    6. NM_001320361.2 → NP_001307290.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    7. NM_001320362.2 → NP_001307291.1  E3 ubiquitin-protein ligase RNF167 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS82040.1
      UniProtKB/Swiss-Prot
      Q9H6Y7
      UniProtKB/TrEMBL
      I3L0L6
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    8. NM_001320363.2 → NP_001307292.1  E3 ubiquitin-protein ligase RNF167 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS82040.1
      UniProtKB/Swiss-Prot
      Q9H6Y7
      UniProtKB/TrEMBL
      I3L0L6
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    9. NM_001320364.2 → NP_001307293.1  E3 ubiquitin-protein ligase RNF167 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS82040.1
      UniProtKB/Swiss-Prot
      Q9H6Y7
      UniProtKB/TrEMBL
      I3L0L6
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    10. NM_001320365.2 → NP_001307294.1  E3 ubiquitin-protein ligase RNF167 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS82040.1
      UniProtKB/Swiss-Prot
      Q9H6Y7
      UniProtKB/TrEMBL
      I3L0L6
      Related
      ENSP00000458189.1, ENST00000576229.5
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    11. NM_001370303.1 → NP_001357232.1  E3 ubiquitin-protein ligase RNF167 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:252 → 297
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    12. NM_001370304.1 → NP_001357233.1  E3 ubiquitin-protein ligase RNF167 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:252 → 297
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    13. NM_001370305.1 → NP_001357234.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    14. NM_001370306.1 → NP_001357235.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:227 → 272
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    15. NM_001370307.1 → NP_001357236.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:227 → 272
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    16. NM_001370308.1 → NP_001357237.1  E3 ubiquitin-protein ligase RNF167 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:217 → 262
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    17. NM_001370311.1 → NP_001357240.1  E3 ubiquitin-protein ligase RNF167 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS82040.1
      Conserved Domains (2) summary
      cd02123
      Location:1 → 135
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:193 → 238
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    18. NM_001370313.1 → NP_001357242.1  E3 ubiquitin-protein ligase RNF167 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Conserved Domains (2) summary
      cd16797
      Location:186 → 231
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
      cl28883
      Location:20 → 128
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

    19. NM_001375485.1 → NP_001362414.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Related
      ENSP00000460190.1, ENST00000575111.5
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    20. NM_015528.3 → NP_056343.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

      See identical proteins and their annotated locations for NP_056343.1

      Status: VALIDATED

      Source sequence(s)
      AC004771
      Consensus CDS
      CCDS11060.1
      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
      Related
      ENSP00000262482.6, ENST00000262482.11
      Conserved Domains (2) summary
      cd02123
      Location:20 → 170
      PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
      cd16797
      Location:228 → 273
      RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      4940092..4945222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435730.1 → XP_047291686.1  E3 ubiquitin-protein ligase RNF167 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4830440..4835570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315676.1 → XP_054171651.1  E3 ubiquitin-protein ligase RNF167 isoform X1

    2. XM_054315675.1 → XP_054171650.1  E3 ubiquitin-protein ligase RNF167 isoform X2

      UniProtKB/Swiss-Prot
      D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H6Y7.1 GenPept UniProtKB/Swiss-Prot:Q9H6Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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