RET ret proto-oncogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: RETprovided by HGNC
Official Full Name: ret proto-oncogeneprovided by HGNC
Primary source: HGNC:HGNC:9967
See related: Ensembl:ENSG00000165731 MIM:164761; AllianceGenome:HGNC:9967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
Summary: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Expression: Biased expression in adrenal (RPKM 10.2), prostate (RPKM 1.3) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q11.21

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (43077069..43130351)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (43954542..44007848)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (43572517..43625799)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points Amid RET Pathogenic Variants in Medullary Thyroid Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2).
Title: Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points Amid RET Pathogenic Variants in Medullary Thyroid Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2).
Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy.
Title: Genomic and Transcriptomic Landscape of RET Wild-Type Medullary Thyroid Cancer and Potential Use of Mitogen-Activated Protein Kinase-Targeted Therapy.
Genotype-specific development of MEN 2 constituent components in 683 RET carriers.
Title: Genotype-specific development of MEN 2 constituent components in 683 RET carriers.
Defining the Genomic Landscape of Diffuse Sclerosing Papillary Thyroid Carcinoma: Prognostic Implications of RET Fusions.
Title: Defining the Genomic Landscape of Diffuse Sclerosing Papillary Thyroid Carcinoma: Prognostic Implications of RET Fusions.
Next-generation sequencing identified that RET variation associates with lymph node metastasis and the immune microenvironment in thyroid papillary carcinoma.
Title: Next-generation sequencing identified that RET variation associates with lymph node metastasis and the immune microenvironment in thyroid papillary carcinoma.
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Title: CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population.
Title: BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population.
Non-syndromic Hirschsprung's disease as a result of a RET gene variant.
Title: Non-syndromic Hirschsprung's disease as a result of a RET gene variant.
Correlation Between the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated with Hashimoto's Thyroiditis, BRAF V600E Gene Mutation, and RET Gene Rearrangement.
Title: Correlation Between the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated with Hashimoto's Thyroiditis, BRAF V600E Gene Mutation, and RET Gene Rearrangement.
Accelerated MEN2A in homozygous RET carriers in the context of consanguinity.
Title: Accelerated MEN2A in homozygous RET carriers in the context of consanguinity.

Submit: New GeneRIF Correction See all GeneRIFs (734)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in RET that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Familial medullary thyroid carcinoma MedGen: C1833921 OMIM: 155240 GeneReviews: Multiple Endocrine Neoplasia Type 2	not available
Hirschsprung disease, susceptibility to, 1 MedGen: C3888239 OMIM: 142623 GeneReviews: Not available	not available
Multiple endocrine neoplasia type 2A MedGen: C0025268 OMIM: 171400 GeneReviews: Multiple Endocrine Neoplasia Type 2	not available
Multiple endocrine neoplasia type 2B MedGen: C0025269 OMIM: 162300 GeneReviews: Multiple Endocrine Neoplasia Type 2	not available
Multiple endocrine neoplasia, type 2 MedGen: C4048306 GeneReviews: Multiple Endocrine Neoplasia Type 2	not available
Pheochromocytoma MedGen: C0031511 OMIM: 171300 GeneReviews: Hereditary Paraganglioma-Pheochromocytoma Syndromes	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2020-08-26) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2020-08-26) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies potential susceptibility Loci for hirschsprung disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T15350 (e-PCR)
- UniSTS:15110

RH66458 (e-PCR)
- UniSTS:20244

D10S1566 (e-PCR)
- UniSTS:23844

PMC23476P2 (e-PCR)
- UniSTS:272204

GDB:574049 (e-PCR)
- UniSTS:157789

GDB:193843 (e-PCR)
- UniSTS:155759

GDB:579598 (e-PCR)
- UniSTS:157821

SHGC-105605 (e-PCR)
- UniSTS:169367

GDB:580702 (e-PCR)
- UniSTS:157848

GDB:281473 (e-PCR)
- UniSTS:156383

GDB:342173 (e-PCR)
- UniSTS:156640

GDB:342177 (e-PCR)
- UniSTS:156641

GDB:592843 (e-PCR)
- UniSTS:157925

G59921 (e-PCR)
- UniSTS:137202

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDF15-GFRAL signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in Peyer's patch morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	TAS Traceable Author Statement more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryonic epithelial tube formation	IEA Inferred from Electronic Annotation more info
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration into lymphoid organs	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in membrane protein proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in neuron cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron maturation	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of metanephric glomerulus development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of neuron maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior midgut development	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in ureter maturation	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of plasma membrane protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase receptor Ret

Names: RET receptor tyrosine kinase; cadherin family member 12; cadherin-related family member 16; proto-oncogene c-Ret; rearranged during transfection; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

NP_001342145.1

EC 2.7.10.1

NP_001393672.1

EC 2.7.10.1

NP_001393673.1

EC 2.7.10.1

NP_001393688.1

EC 2.7.10.1

NP_001393689.1

EC 2.7.10.1

NP_001393690.1

EC 2.7.10.1

NP_001393691.1

EC 2.7.10.1

NP_001393692.1

EC 2.7.10.1

NP_001393693.1

EC 2.7.10.1

NP_001393694.1

EC 2.7.10.1

NP_001393695.1

EC 2.7.10.1

NP_001393696.1

EC 2.7.10.1

NP_001393697.1

EC 2.7.10.1

NP_001393698.1

EC 2.7.10.1

NP_001393699.1

EC 2.7.10.1

NP_001393700.1

EC 2.7.10.1

NP_001393701.1

EC 2.7.10.1

NP_001393702.1

EC 2.7.10.1

NP_001393703.1

EC 2.7.10.1

NP_001393704.1

EC 2.7.10.1

NP_001393705.1

EC 2.7.10.1

NP_001393706.1

EC 2.7.10.1

NP_001393707.1

EC 2.7.10.1

NP_001393708.1

EC 2.7.10.1

NP_001393709.1

EC 2.7.10.1

NP_001393710.1

EC 2.7.10.1

NP_001393711.1

EC 2.7.10.1

NP_001393712.1

EC 2.7.10.1

NP_001393713.1

EC 2.7.10.1

NP_001393714.1

EC 2.7.10.1

NP_001393715.1

EC 2.7.10.1

NP_001393716.1

EC 2.7.10.1

NP_001393717.1

EC 2.7.10.1

NP_001393718.1

EC 2.7.10.1

NP_001393719.1

EC 2.7.10.1

NP_001393720.1

EC 2.7.10.1

NP_001393721.1

EC 2.7.10.1

NP_001393722.1

EC 2.7.10.1

NP_001393723.1

EC 2.7.10.1

NP_065681.1

EC 2.7.10.1

NP_066124.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007489.1 RefSeqGene

Range

5001..58283

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_518

mRNA and Protein(s)

NM_001355216.2 → NP_001342145.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform d

Status: REVIEWED

Source sequence(s)

AC010864

UniProtKB/TrEMBL

B4DGX8

Related

ENST00000683007.1

Conserved Domains (1) summary

cd05045
Location:469 → 758

PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
NM_001406743.1 → NP_001393672.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

Status: REVIEWED

Source sequence(s)

AC010864

UniProtKB/Swiss-Prot

A8K6Z2, P07949, Q9BTB0
NM_001406744.1 → NP_001393673.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406759.1 → NP_001393688.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform e precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406760.1 → NP_001393689.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform e precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406761.1 → NP_001393690.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform f precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406762.1 → NP_001393691.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform f precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406763.1 → NP_001393692.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform g precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406764.1 → NP_001393693.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform h precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406765.1 → NP_001393694.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform i precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406766.1 → NP_001393695.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform j precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406767.1 → NP_001393696.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform j precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406768.1 → NP_001393697.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform k precursor

Status: REVIEWED

Source sequence(s)

AC010864

UniProtKB/TrEMBL

A0AAQ5BH28

Related

ENSP00000519223.1, ENST00000713926.1
NM_001406769.1 → NP_001393698.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform l precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406770.1 → NP_001393699.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform m precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406771.1 → NP_001393700.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform n precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406772.1 → NP_001393701.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform o precursor

Status: REVIEWED

Source sequence(s)

AC010864

UniProtKB/TrEMBL

A0A087WWB1

Related

ENSP00000480088.2, ENST00000615310.5
NM_001406773.1 → NP_001393702.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform p precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406774.1 → NP_001393703.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform q precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406775.1 → NP_001393704.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform r precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406776.1 → NP_001393705.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform s precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406777.1 → NP_001393706.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform t precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406778.1 → NP_001393707.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform u precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406779.1 → NP_001393708.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform v precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406780.1 → NP_001393709.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform v precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406781.1 → NP_001393710.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform w precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406782.1 → NP_001393711.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform x precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406783.1 → NP_001393712.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform y precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406784.1 → NP_001393713.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform z precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406785.1 → NP_001393714.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform aa precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406786.1 → NP_001393715.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform bb precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406787.1 → NP_001393716.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform cc precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406788.1 → NP_001393717.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform dd precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406789.1 → NP_001393718.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform dd precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406790.1 → NP_001393719.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform ff precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406791.1 → NP_001393720.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform gg precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406792.1 → NP_001393721.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform hh precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406793.1 → NP_001393722.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform ii precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_001406794.1 → NP_001393723.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform jj precursor

Status: REVIEWED

Source sequence(s)

AC010864
NM_020630.7 → NP_065681.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

See identical proteins and their annotated locations for NP_065681.1

Status: REVIEWED

Source sequence(s)

AC010864

Consensus CDS

CCDS53525.1

UniProtKB/TrEMBL

F8TLW0

Related

ENSP00000344798.4, ENST00000340058.6

Conserved Domains (3) summary

cd05045
Location:723 → 1012

PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein

pfam00028
Location:172 → 261

Cadherin; Cadherin domain

pfam07714
Location:724 → 1005

Pkinase_Tyr; Protein tyrosine kinase
NM_020975.6 → NP_066124.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

See identical proteins and their annotated locations for NP_066124.1

Status: REVIEWED

Source sequence(s)

AC010864, BC003072, BC004257, BM661773, X12949

Consensus CDS

CCDS7200.1

UniProtKB/Swiss-Prot

A8K6Z2, P07949, Q9BTB0

UniProtKB/TrEMBL

F8TLW0

Related

ENSP00000347942.3, ENST00000355710.8

Conserved Domains (3) summary

cd05045
Location:723 → 1012

PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein

pfam00028
Location:172 → 261

Cadherin; Cadherin domain

pfam07714
Location:724 → 1005

Pkinase_Tyr; Protein tyrosine kinase