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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001130861.1 → NP_001124333.1 claudin-5 isoform 1
See identical proteins and their annotated locations for NP_001124333.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes a protein of 303 aa (isoform 1). A common SNP (rs885985) encodes a stop codon in the 5' coding region and thus, for some haplotypes, translation is predicted to initiate from a downstream AUG to produce a protein of 218 aa (isoform 2).
- Source sequence(s)
-
AK092561, AK124019, BU688528
- Consensus CDS
-
CCDS13763.2
- UniProtKB/TrEMBL
-
D3DX19
- Related
- ENSP00000384554.1, ENST00000403084.1
- Conserved Domains (1) summary
-
- cl21598
Location:90 → 266
- PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
-
NM_001363066.2 → NP_001349995.1 claudin-5 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents the predominant transcript and initiates transcription from a downstream promoter, compared to variant 1. It encodes a protein of 218 aa (isoform 2) with a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC000082, AK124019, BC032363
- Consensus CDS
-
CCDS93118.1
- UniProtKB/Swiss-Prot
- B3KS11, O00501, Q53XW2, Q8WUW3
- UniProtKB/TrEMBL
-
Q53HW4
- Related
- ENSP00000480623.1, ENST00000618236.2
- Conserved Domains (1) summary
-
- cl21598
Location:5 → 181
- PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
-
NM_001363067.2 → NP_001349996.1 claudin-5 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes a protein (isoform 1) of 303 aa. A common SNP (rs885985) encodes a stop codon in the 5' coding region and thus, for some haplotypes, translation is predicted to initiate from a downstream AUG to produce a protein of 218 aa (isoform 2).
- Source sequence(s)
-
AC000082
- Consensus CDS
-
CCDS13763.2
- UniProtKB/TrEMBL
-
D3DX19
- Conserved Domains (1) summary
-
- cl21598
Location:90 → 266
- PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
-
NM_001426402.1 → NP_001413331.1 claudin-5 isoform 2
Status: REVIEWED
- Source sequence(s)
-
CP068256
- UniProtKB/Swiss-Prot
- B3KS11, O00501, Q53XW2, Q8WUW3
- UniProtKB/TrEMBL
-
Q53HW4
-
NM_003277.4 → NP_003268.2 claudin-5 isoform 1
See identical proteins and their annotated locations for NP_003268.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes a protein (isoform 1) of 303 aa. A common SNP (rs885985) encodes a stop codon in the 5' coding region and thus, for some haplotypes, translation is predicted to initiate from a downstream AUG to produce a protein of 218 aa (isoform 2).
- Source sequence(s)
-
AK092561, DB023636
- Consensus CDS
-
CCDS13763.2
- UniProtKB/TrEMBL
-
D3DX19
- Related
- ENSP00000400612.2, ENST00000413119.2
- Conserved Domains (1) summary
-
- cl21598
Location:90 → 266
- PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
19523024..19525337 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
19899865..19902178 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)