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    XPO6 exportin 6 [ Homo sapiens (human) ]

    Gene ID: 23214, updated on 9-Dec-2024

    Summary

    Official Symbol
    XPO6provided by HGNC
    Official Full Name
    exportin 6provided by HGNC
    Primary source
    HGNC:HGNC:19733
    See related
    Ensembl:ENSG00000169180 MIM:608411; AllianceGenome:HGNC:19733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EXP6; RANBP20
    Summary
    The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in testis (RPKM 30.3), spleen (RPKM 24.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See XPO6 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28097976..28211965, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28378417..28492441, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28109297..28223286, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GSG1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27878335-27878836 Neighboring gene RNA, U6 small nuclear 159, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:27960751-27960921 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:28004462-28005661 Neighboring gene RNA, U6 small nuclear 1241, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:28030002-28031201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28037919-28038419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28102727-28103678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28108651-28109150 Neighboring gene uncharacterized LOC124903669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10636 Neighboring gene NANOG hESC enhancer GRCh37_chr16:28157890-28158405 Neighboring gene TP53RK binding protein pseudogene 2 Neighboring gene uncharacterized LOC124900376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7305 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28203444-28203616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10639 Neighboring gene Sharpr-MPRA regulatory region 6679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28222406-28223404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28230517-28231018 Neighboring gene RNY1 pseudogene 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28234253-28235103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28271835-28272335 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 11993 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene SH3 domain binding kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22519, KIAA0370

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    exportin-6
    Names
    ran-binding protein 20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270940.2NP_001257869.1  exportin-6 isoform 1

      See identical proteins and their annotated locations for NP_001257869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform (1).
      Source sequence(s)
      AB002368, AC136611, AK026172, AK123846, AY026388, BI465054, BX346769
      Consensus CDS
      CCDS59266.1
      UniProtKB/TrEMBL
      B3KW08
      Related
      ENSP00000457341.1, ENST00000565698.5
      Conserved Domains (2) summary
      smart00913
      Location:1782
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:89263
      Xpo1; Exportin 1-like protein
    2. NM_015171.4NP_055986.1  exportin-6 isoform 2

      See identical proteins and their annotated locations for NP_055986.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AB002368, AC136611, AK026172, AY026388, BI465054, BX346769
      Consensus CDS
      CCDS42135.1
      UniProtKB/Swiss-Prot
      A1L3W4, D3DWF9, Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q96QU8, Q9BT21
      UniProtKB/TrEMBL
      B7ZM10
      Related
      ENSP00000302790.4, ENST00000304658.10
      Conserved Domains (2) summary
      smart00913
      Location:3196
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103253
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28097976..28211965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28378417..28492441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)