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    EPHA6 EPH receptor A6 [ Homo sapiens (human) ]

    Gene ID: 285220, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EPHA6provided by HGNC
    Official Full Name
    EPH receptor A6provided by HGNC
    Primary source
    HGNC:HGNC:19296
    See related
    Ensembl:ENSG00000080224 MIM:600066; AllianceGenome:HGNC:19296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See EPHA6 in Genome Data Viewer
    Location:
    3q11.2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (96814594..97761532)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (99518416..100468755)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (96533438..97480376)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:96513110-96513654 Neighboring gene uncharacterized LOC124909397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14551 Neighboring gene CDV3 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:96606342-96607541 Neighboring gene uncharacterized LOC107986103 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:96844549-96845271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:96995547-96996405 Neighboring gene uncharacterized LOC101929278 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97108697-97109268 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97107500-97108060 Neighboring gene TPTE2 pseudogene 7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97381594-97382192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97406521-97407050 Neighboring gene NANOG hESC enhancer GRCh37_chr3:97430329-97430833 Neighboring gene uncharacterized LOC124906256 Neighboring gene NANOG hESC enhancer GRCh37_chr3:97466009-97466510 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:97482933-97483434 and GRCh37_chr3:97483435-97483934 Neighboring gene uncharacterized LOC101929298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14552 Neighboring gene uncharacterized LOC105373994 Neighboring gene ARF like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression. Li S, et al. Oncotarget, 2015 Sep 8. PMID 26041887, Free PMC Article
    2. Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Hafner C, et al. Clin Chem, 2004 Mar. PMID 14726470
    3. EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population. Kim M, et al. Lipids Health Dis, 2017 Dec 6. PMID 29208002, Free PMC Article
    4. Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance. Kozulin P, et al. Mol Vis, 2009 Dec 9. PMID 20011078, Free PMC Article
    5. Eph receptors in the adult brain. Yamaguchi Y, et al. Curr Opin Neurobiol, 2004 Jun. PMID 15194108

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data imply that EPHA6 expression is beneficial for glioblastoma multiforme inhibition, particularly in combination with activation of BMP-2 signaling.These results suggest that EPHA6 expression or protein levels could be used as biomarkers for identification of subsets of glioblastoma multiforme patients who might benefit from BMP treatment.
      Title: Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.
    2. The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population.
      Title: EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population.
    3. Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy
      Title: Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.
    4. EphA6 mRNA expression is higher in 112 CaP tumor samples compared with benign tissues from 58 benign prostate hyperplasia patients. Positive correlation was identified between EphA6 expression and vascular invasion, neural invasion, PSA level, and TNM staging in CaP cases.
      Title: EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression.
    5. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes.
      Title: Novel recurrently mutated genes in African American colon cancers.
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide study reveals copy number variants exclusive to childhood obesity cases.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. During development of the retinal vasculature, migration of ligand-bearing astrocytes is slowed along Eph-A6 expression gradient through repellent Eph-A6 - ephrin-A1 and -A4 signaling.
      Title: Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance.
    9. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35246, DKFZp434C1418

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 6
    Names
    EPH homology kinase 2
    EPH-like kinase 12
    ephrin receptor EphA6
    NP_001073917.2
    NP_001265229.1
    NP_001265230.1
    NP_775926.1
    XP_006713655.1
    XP_011511007.1
    XP_011511008.1
    XP_011511009.1
    XP_016861699.1
    XP_016861700.1
    XP_016861701.1
    XP_016861702.1
    XP_016861703.1
    XP_016861704.2
    XP_016861705.2
    XP_016861706.1
    XP_016861707.1
    XP_016861708.1
    XP_047303964.1
    XP_047303965.1
    XP_054202245.1
    XP_054202246.1
    XP_054202247.1
    XP_054202248.1
    XP_054202249.1
    XP_054202250.1
    XP_054202251.1
    XP_054202252.1
    XP_054202253.1
    XP_054202254.1
    XP_054202255.1
    XP_054202256.1
    XP_054202257.1
    XP_054202258.1
    XP_054202259.1
    XP_054202260.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080448.3 → NP_001073917.2  ephrin type-A receptor 6 isoform a

      See identical proteins and their annotated locations for NP_001073917.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC107482, AC110491, AC117439, AC117470, AC119745, AC130510, AC135369, BM676895, DA385338
      Consensus CDS
      CCDS46876.1
      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33
      UniProtKB/TrEMBL
      A0A0B4J1T8
      Related
      ENSP00000374323.5, ENST00000389672.10
      Conserved Domains (8) summary
      cd09547
      Location:1055 → 1118
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      smart00454
      Location:1052 → 1119
      SAM; Sterile alpha motif
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      cd00063
      Location:537 → 628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:720 → 1028
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:427 → 521
      fn3; Fibronectin type III domain
      pfam07714
      Location:725 → 1024
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:648 → 720
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. NM_001278300.2 → NP_001265229.1  ephrin type-A receptor 6 isoform c

      See identical proteins and their annotated locations for NP_001265229.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences at the 5' and 3' ends, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (c) is shorter and has distinct N- and C- termini, compared to isoform a.
      Source sequence(s)
      AC117439, AC117470, AL133666, BC067287, DC398430
      Consensus CDS
      CCDS63697.1
      UniProtKB/Swiss-Prot
      Q9UF33
      Related
      ENSP00000421711.1, ENST00000514100.5
      Conserved Domains (3) summary
      pfam07714
      Location:117 → 320
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:40 → 112
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:112 → 320
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001278301.2 → NP_001265230.1  ephrin type-A receptor 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' exons, and includes an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC119745, AY358738, DA385338
      UniProtKB/TrEMBL
      H0Y9V0
      Related
      ENSP00000425132.1, ENST00000506569.1
      Conserved Domains (1) summary
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6

    4. NM_173655.4 → NP_775926.1  ephrin type-A receptor 6 isoform b

      See identical proteins and their annotated locations for NP_775926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences at the 5' and 3' ends, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has distinct N- and C- termini, compared to isoform a.
      Source sequence(s)
      AL133666, DC398430
      Consensus CDS
      CCDS54616.1
      UniProtKB/Swiss-Prot
      Q9UF33
      Related
      ENSP00000423950.1, ENST00000502694.1
      Conserved Domains (3) summary
      pfam07714
      Location:117 → 321
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:40 → 112
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:112 → 320
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      96814594..97761532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006211.2 → XP_016861700.1  ephrin type-A receptor 6 isoform X4

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33
      Conserved Domains (8) summary
      cd09547
      Location:943 → 1006
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      smart00454
      Location:940 → 1007
      SAM; Sterile alpha motif
      cd00063
      Location:409 → 516
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:608 → 916
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:299 → 393
      fn3; Fibronectin type III domain
      pfam07714
      Location:613 → 912
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:536 → 608
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:23 → 172
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    2. XM_006713592.4 → XP_006713655.1  ephrin type-A receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33
      Conserved Domains (8) summary
      cd09547
      Location:1071 → 1134
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      smart00454
      Location:1068 → 1135
      SAM; Sterile alpha motif
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      cd00063
      Location:537 → 644
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:736 → 1044
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:427 → 521
      fn3; Fibronectin type III domain
      pfam07714
      Location:741 → 1040
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:664 → 736
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_017006210.2 → XP_016861699.1  ephrin type-A receptor 6 isoform X2

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    4. XM_047448008.1 → XP_047303964.1  ephrin type-A receptor 6 isoform X3

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    5. XM_017006214.2 → XP_016861703.1  ephrin type-A receptor 6 isoform X7

    6. XM_017006219.2 → XP_016861708.1  ephrin type-A receptor 6 isoform X11

      UniProtKB/TrEMBL
      E7EU71
      Related
      ENSP00000420598.2, ENST00000470610.6

    7. XM_011512705.3 → XP_011511007.1  ephrin type-A receptor 6 isoform X13

      Conserved Domains (1) summary
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6

    8. XM_011512706.3 → XP_011511008.1  ephrin type-A receptor 6 isoform X14

      UniProtKB/TrEMBL
      H0Y9V0
      Conserved Domains (1) summary
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6

    9. XM_011512707.3 → XP_011511009.1  ephrin type-A receptor 6 isoform X15

      UniProtKB/TrEMBL
      H0Y9V0
      Conserved Domains (1) summary
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6

    10. XM_017006212.1 → XP_016861701.1  ephrin type-A receptor 6 isoform X5

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    11. XM_017006213.2 → XP_016861702.1  ephrin type-A receptor 6 isoform X6

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33
      Conserved Domains (8) summary
      cd09547
      Location:915 → 978
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      smart00454
      Location:912 → 979
      SAM; Sterile alpha motif
      cd00063
      Location:381 → 488
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:580 → 888
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:271 → 365
      fn3; Fibronectin type III domain
      pfam07714
      Location:585 → 884
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:508 → 580
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 144
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    12. XM_017006218.1 → XP_016861707.1  ephrin type-A receptor 6 isoform X10

    13. XM_017006217.2 → XP_016861706.1  ephrin type-A receptor 6 isoform X9

    14. XM_017006215.2 → XP_016861704.2  ephrin type-A receptor 6 isoform X8

    15. XM_017006216.2 → XP_016861705.2  ephrin type-A receptor 6 isoform X8

    16. XM_047448009.1 → XP_047303965.1  ephrin type-A receptor 6 isoform X12

    RNA

    1. XR_001740110.2 RNA Sequence

    2. XR_924126.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      99518416..100468755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346273.1 → XP_054202248.1  ephrin type-A receptor 6 isoform X4

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    2. XM_054346270.1 → XP_054202245.1  ephrin type-A receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    3. XM_054346271.1 → XP_054202246.1  ephrin type-A receptor 6 isoform X2

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    4. XM_054346272.1 → XP_054202247.1  ephrin type-A receptor 6 isoform X3

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    5. XM_054346276.1 → XP_054202251.1  ephrin type-A receptor 6 isoform X7

    6. XM_054346281.1 → XP_054202256.1  ephrin type-A receptor 6 isoform X11

      UniProtKB/TrEMBL
      E7EU71

    7. XM_054346283.1 → XP_054202258.1  ephrin type-A receptor 6 isoform X13

    8. XM_054346284.1 → XP_054202259.1  ephrin type-A receptor 6 isoform X14

      UniProtKB/TrEMBL
      H0Y9V0

    9. XM_054346285.1 → XP_054202260.1  ephrin type-A receptor 6 isoform X15

      UniProtKB/TrEMBL
      H0Y9V0

    10. XM_054346274.1 → XP_054202249.1  ephrin type-A receptor 6 isoform X5

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    11. XM_054346275.1 → XP_054202250.1  ephrin type-A receptor 6 isoform X6

      UniProtKB/Swiss-Prot
      D6RAL5, Q9UF33

    12. XM_054346280.1 → XP_054202255.1  ephrin type-A receptor 6 isoform X10

    13. XM_054346279.1 → XP_054202254.1  ephrin type-A receptor 6 isoform X9

    14. XM_054346277.1 → XP_054202252.1  ephrin type-A receptor 6 isoform X8

    15. XM_054346278.1 → XP_054202253.1  ephrin type-A receptor 6 isoform X8

    16. XM_054346282.1 → XP_054202257.1  ephrin type-A receptor 6 isoform X12

    RNA

    1. XR_008486700.1 RNA Sequence

    2. XR_008486701.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UF33.3 GenPept UniProtKB/Swiss-Prot:Q9UF33

    Gene LinkOut

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