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    ZNF761 zinc finger protein 761 [ Homo sapiens (human) ]

    Gene ID: 388561, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF761provided by HGNC
    Official Full Name
    zinc finger protein 761provided by HGNC
    Primary source
    HGNC:HGNC:23179
    See related
    Ensembl:ENSG00000160336 AllianceGenome:HGNC:23179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF468
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in prostate (RPKM 24.8), placenta (RPKM 5.8) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF761 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53431984..53458261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56511539..56537815)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53935237..53961515)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF765-ZNF761 readthrough Neighboring gene zinc finger protein 765 Neighboring gene ribosomal protein L39 pseudogene 36 Neighboring gene vomeronasal 1 receptor 101 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11010 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971207-53971768 Neighboring gene vomeronasal 1 receptor 102 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971769-53972331 Neighboring gene zinc finger protein 813 Neighboring gene tropomyosin 3 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article
    2. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 761 (ZNF761) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF765-ZNF761

    Readthrough gene: ZNF765-ZNF761, Included gene: ZNF765, Included gene: ZNF525

    Homology

    Clone Names

    • FLJ16231, FLJ35333, KIAA2033, MGC87789

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 761
    Names
    zinc finger protein 468

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008401.4 → NP_001008401.3  zinc finger protein 761 isoform a

      See identical proteins and their annotated locations for NP_001008401.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 all encode the same isoform.
      Source sequence(s)
      AB107355, AC022137, BM977910, DA237674
      UniProtKB/Swiss-Prot
      A0A087WXT7, Q6ZNB9, Q86XN6
      Conserved Domains (4) summary
      COG5048
      Location:242 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:651 → 737
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    2. NM_001289951.2 → NP_001276880.1  zinc finger protein 761 isoform a

      See identical proteins and their annotated locations for NP_001276880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
      Source sequence(s)
      AC022137, BM977910, DA237674, DB232487
      UniProtKB/Swiss-Prot
      A0A087WXT7, Q6ZNB9, Q86XN6
      Related
      ENSP00000507666.1, ENST00000684525.1
      Conserved Domains (4) summary
      COG5048
      Location:242 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:651 → 737
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    3. NM_001289952.1 → NP_001276881.1  zinc finger protein 761 isoform a

      See identical proteins and their annotated locations for NP_001276881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
      Source sequence(s)
      AB107355, AC022137, BM977910, DB232487
      UniProtKB/Swiss-Prot
      A0A087WXT7, Q6ZNB9, Q86XN6
      Related
      ENSP00000480218.1, ENST00000432094.6
      Conserved Domains (4) summary
      COG5048
      Location:242 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:651 → 737
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box

    4. NM_001289953.1 → NP_001276882.1  zinc finger protein 761 isoform b

      See identical proteins and their annotated locations for NP_001276882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs, and contains an alternate 3' terminal exon and thus differs in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      BC071639, BC103708, DB232487
      Consensus CDS
      CCDS77353.1
      UniProtKB/TrEMBL
      Q6IQ01
      Related
      ENSP00000481271.1, ENST00000613950.1
      Conserved Domains (2) summary
      smart00349
      Location:8 → 50
      KRAB; krueppel associated box
      pfam01352
      Location:8 → 47
      KRAB; KRAB box

    RNA

    1. NR_110551.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC071639, BC103708, DA237674, DB232487
      Related
      ENST00000610928.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53431984..53458261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56511539..56537815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XN6.3 GenPept UniProtKB/Swiss-Prot:Q86XN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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