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    GPR139 G protein-coupled receptor 139 [ Homo sapiens (human) ]

    Gene ID: 124274, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR139provided by HGNC
    Official Full Name
    G protein-coupled receptor 139provided by HGNC
    Primary source
    HGNC:HGNC:19995
    See related
    Ensembl:ENSG00000180269 MIM:618448; AllianceGenome:HGNC:19995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR3; GPRg1
    Summary
    This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR139 in Genome Data Viewer
    Location:
    16p12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (20028239..20073890, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19959033..20004824, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20039561..20085212, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371116 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:19980466-19980966 Neighboring gene uncharacterized LOC105371117 Neighboring gene uncharacterized LOC124903660 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:20031023-20032222 Neighboring gene MPRA-validated peak2522 silencer Neighboring gene spalt like transcription factor 4 pseudogene 3 Neighboring gene uncharacterized LOC102723396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139. Pallareti L, et al. Eur J Pharmacol, 2023 Mar 15. PMID 36736525
    2. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor. Dvorak CA, et al. ACS Med Chem Lett, 2015 Sep 10. PMID 26396690, Free PMC Article
    3. Computer-aided discovery of aromatic l-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. Isberg V, et al. J Chem Inf Model, 2014 Jun 23. PMID 24826842
    4. Copy number variation distribution in six monozygotic twin pairs discordant for schizophrenia. Castellani CA, et al. Twin Res Hum Genet, 2014 Apr. PMID 24556202
    5. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. Hu LA, et al. J Biomol Screen, 2009 Aug. PMID 19525486

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular cloning of GPRg1, a Gq-coupled orphan receptor that is expressed in the brain.
      Title: Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 139
    Names
    G protein-coupled receptor PGR3
    g(q)-coupled orphan receptor GPRg1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002911.4 → NP_001002911.1  probable G-protein coupled receptor 139 isoform 1

      See identical proteins and their annotated locations for NP_001002911.1

      Status: REVIEWED

      Source sequence(s)
      AC021089, AK291384, BC137237
      Consensus CDS
      CCDS32398.1
      UniProtKB/Swiss-Prot
      A8K5R9, Q6DWJ6, Q86SP2, Q8TDU8
      UniProtKB/TrEMBL
      A0A0I9QQP3, A0A142CHG1
      Related
      ENSP00000458791.2, ENST00000570682.2
      Conserved Domains (1) summary
      cd15919
      Location:27 → 296
      7tmA_GPR139; G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001318483.1 → NP_001305412.1  probable G-protein coupled receptor 139 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-ternimus, compared to isoform 1.
      Source sequence(s)
      AK291384, BC144547, DN693347
      UniProtKB/Swiss-Prot
      Q6DWJ6
      Conserved Domains (2) summary
      cd14964
      Location:8 → 38
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      20028239..20073890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      19959033..20004824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DWJ6.1 GenPept UniProtKB/Swiss-Prot:Q6DWJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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