U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MIR130A microRNA 130a [ Homo sapiens (human) ]

    Gene ID: 406919, updated on 10-Dec-2024

    Summary

    Official Symbol
    MIR130Aprovided by HGNC
    Official Full Name
    microRNA 130aprovided by HGNC
    Primary source
    HGNC:HGNC:31514
    See related
    Ensembl:ENSG00000208009 MIM:610175; miRBase:MI0000448; AllianceGenome:HGNC:31514
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRN130A; mir-130a; miRNA130A
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MIR130A in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57641198..57641286)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57591382..57591470)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57408671..57408759)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:57349879-57350046 Neighboring gene serpin family G member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3353 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57406889-57407468 Neighboring gene MIR130A host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57410743-57411242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4725 Neighboring gene yippee like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4726 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Other Names

    • hsa-mir-130a

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA base-pairing translational repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of negative regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of negative regulation of epithelial to mesenchymal transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of regulation of transformation of host cell by virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_029673.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AP000662
      Related
      ENST00000385274.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57641198..57641286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57591382..57591470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)