U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CDNF cerebral dopamine neurotrophic factor [ Homo sapiens (human) ]

    Gene ID: 441549, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CDNFprovided by HGNC
    Official Full Name
    cerebral dopamine neurotrophic factorprovided by HGNC
    Primary source
    HGNC:HGNC:24913
    See related
    Ensembl:ENSG00000185267 MIM:611233; AllianceGenome:HGNC:24913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARMETL1
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 6.6), thyroid (RPKM 2.2) and 23 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CDNF in Genome Data Viewer
    Location:
    10p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14819245..14838037, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14833219..14852002, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14861244..14880036, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:14716743-14717329 Neighboring gene RNA, 5S ribosomal pseudogene 302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14779811-14780332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14793464-14794381 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3085 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 divergent transcript

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease. Nam J, et al. Sci Rep, 2024 Jul 17. PMID 39019902, Free PMC Article
    2. Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. Lohoff FW, et al. Neurosci Lett, 2009 Apr 10. PMID 19429035, Free PMC Article
    3. Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. Choi JM, et al. Neurosci Lett, 2011 Apr 15. PMID 21320571
    4. Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. Nadella R, et al. J Neuroinflammation, 2014 Dec 16. PMID 25511018, Free PMC Article
    5. Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. Kemppainen S, et al. Behav Brain Res, 2015 Sep 15. PMID 25975173

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease.
      Title: Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease.
    2. Cerebral dopamine neurotrophic factor reduces alpha-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
      Title: Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.
    3. Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs.
      Title: Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs.
    4. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon.
      Title: Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon.
    5. Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential.
      Title: Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential.
    6. Cerebral dopamine neurotrophic factor gene expression was significantly reduced in stroke patients relative to control subjects.
      Title: Decreased Expression of Cerebral Dopamine Neurotrophic Factor in Platelets of Stroke Patients.
    7. Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia.
      Title: Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.
    8. In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis.
      Title: Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.
    9. The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion).
      Title: Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression.
    10. Results suggest that CDNF treatment selectively enhances long-term memory consolidation
      Title: Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dopaminergic neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cerebral dopamine neurotrophic factor
    Names
    ARMET-like protein 1
    arginine-rich, mutated in early stage tumors-like 1
    conserved dopamine neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029954.3 → NP_001025125.2  cerebral dopamine neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_001025125.2

      Status: VALIDATED

      Source sequence(s)
      AC069544, AK131035, AV657190, BG213461, BQ025443, CN311321
      Consensus CDS
      CCDS31148.1
      UniProtKB/Swiss-Prot
      A2RUU0, B4DVW3, Q49AH0
      Related
      ENSP00000419395.1, ENST00000465530.2
      Conserved Domains (1) summary
      pfam10208
      Location:36 → 180
      Armet; Degradation arginine-rich protein for mis-folding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      14819245..14838037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519488.3 → XP_011517790.1  cerebral dopamine neurotrophic factor isoform X1

      Conserved Domains (1) summary
      pfam10208
      Location:36 → 189
      Armet; Degradation arginine-rich protein for mis-folding

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      14833219..14852002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365950.1 → XP_054221925.1  cerebral dopamine neurotrophic factor isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49AH0.2 GenPept UniProtKB/Swiss-Prot:Q49AH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools