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    SPRED3 sprouty related EVH1 domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 399473, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SPRED3provided by HGNC
    Official Full Name
    sprouty related EVH1 domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:31041
    See related
    Ensembl:ENSG00000188766 MIM:609293; AllianceGenome:HGNC:31041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Eve-3; spred-3
    Summary
    This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in brain (RPKM 1.8), duodenum (RPKM 0.4) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPRED3 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38388697..38399587)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41190872..41201764)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38879337..38890227)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38865120-38865750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10571 Neighboring gene Sharpr-MPRA regulatory region 13764 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38890799-38890957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10573 Neighboring gene gametogenetin Neighboring gene family with sequence similarity 98 member C Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38917687-38918201 Neighboring gene MPRA-validated peak3471 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38925085-38925660 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38932363-38932538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38932982-38933942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38943427-38943954 Neighboring gene MPRA-validated peak3472 silencer Neighboring gene ryanodine receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38953733-38954234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38954745-38955341 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38969337-38969680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38986475-38987366 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:38995830-38997029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14573 Neighboring gene uncharacterized LOC124904710

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation. Chen Z, et al. Sci Rep, 2024 Sep 3. PMID 39227612, Free PMC Article
    2. Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma. Zhang X, et al. Sci Rep, 2024 Feb 24. PMID 38402263, Free PMC Article
    3. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. King JA, et al. J Hepatol, 2006 Apr. PMID 16478641
    4. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. Mizoguchi M, et al. Neurogenetics, 2004 Feb. PMID 14618415
    5. Sprouty proteins: modified modulators, matchmakers or missing links? Guy GR, et al. J Endocrinol, 2009 Nov. PMID 19423641

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPRED3 regulates the NF-kappaB signaling pathway in thyroid cancer and promotes the proliferation.
      Title: SPRED3 regulates the NF-κB signaling pathway in thyroid cancer and promotes the proliferation.
    2. Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma.
      Title: Bioinformatics analysis for the identification of Sprouty-related EVH1 domain-containing protein 3 expression and its clinical significance in thyroid carcinoma.
    3. Eve-3 may act as an inhibitor of proliferation pathways in the mature liver and be involved in modulating the unique regenerative capacity of this organ
      Title: Eve-3: a liver enriched suppressor of Ras/MAPK signaling.
    4. The finding of Spred-3 revealed the presence of a novel family of regulators for the Ras/MAP kinase pathway, each member of which may have different specificities for extracellular signals. [Spred-3]
      Title: Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC005789.11

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042522.3 → NP_001035987.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001035987.1

      Status: REVIEWED

      Source sequence(s)
      AC005789
      Consensus CDS
      CCDS42560.1
      UniProtKB/Swiss-Prot
      Q2MJR0, Q2MJR1
      UniProtKB/TrEMBL
      B9EKV1
      Related
      ENSP00000345405.4, ENST00000338502.8
      Conserved Domains (2) summary
      cd10574
      Location:2 → 105
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296 → 400
      Sprouty; Sprouty protein (Spry)

    2. NM_001394336.1 → NP_001381265.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC005789
      Consensus CDS
      CCDS42560.1
      UniProtKB/Swiss-Prot
      Q2MJR0, Q2MJR1
      UniProtKB/TrEMBL
      B9EKV1
      Related
      ENSP00000510478.1, ENST00000691638.1
      Conserved Domains (2) summary
      cd10574
      Location:2 → 105
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296 → 400
      Sprouty; Sprouty protein (Spry)

    3. NM_001394337.1 → NP_001381266.1  sprouty-related, EVH1 domain-containing protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC005789
      UniProtKB/TrEMBL
      B9EKV1
      Conserved Domains (1) summary
      cd10574
      Location:2 → 105
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

    4. NM_001394338.1 → NP_001381267.1  sprouty-related, EVH1 domain-containing protein 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005789

    RNA

    1. NR_073032.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005789

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      38388697..38399587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41190872..41201764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039616.1: Suppressed sequence

      Description
      NM_001039616.1: This RefSeq was suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2MJR0.1 GenPept UniProtKB/Swiss-Prot:Q2MJR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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