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    PRB3 proline rich protein BstNI subfamily 3 [ Homo sapiens (human) ]

    Gene ID: 5544, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRB3provided by HGNC
    Official Full Name
    proline rich protein BstNI subfamily 3provided by HGNC
    Primary source
    HGNC:HGNC:9339
    See related
    Ensembl:ENSG00000197870 MIM:168840; AllianceGenome:HGNC:9339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G1; PRG
    Summary
    This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward salivary gland (RPKM 9550.6) See more
    Orthologs
    all
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    Genomic context

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    See PRB3 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11265914..11269707, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (11135147..11138817, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11418847..11422641, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987435 Neighboring gene taste 2 receptor member 7 pseudogene Neighboring gene taste 2 receptor member 42 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:11443165-11443666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:11443667-11444166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:11450808-11451403 Neighboring gene proline rich protein BstNI subfamily 4 Neighboring gene proline rich protein BstNI subfamily 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein. Gillece-Castro BL, et al. J Biol Chem, 1991 Sep 15. PMID 1894623
    2. Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew. Azen EA, et al. Am J Hum Genet, 1990 Oct. PMID 2171329, Free PMC Article
    3. Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. Wang F, et al. J Neurooncol, 2014 Jan. PMID 24135847
    4. PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. Azen E, et al. Infect Immun, 1993 Oct. PMID 8406834, Free PMC Article
    5. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. Helmerhorst EJ, et al. J Biol Chem, 2008 Jul 18. PMID 18463091, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of this study suggested that low levels of PRB3 mRNA may have a role in dopamine-agonist resistance and tumor recurrence of prolactinomas.
      Title: Low levels of PRB3 mRNA are associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116862, MGC116863, MGC116864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basic salivary proline-rich protein 3
    Names
    BstNI type basic salivary proline-rich protein 3
    G1 parotid salivary glycoprotein
    parotid salivary glycoprotein G1
    proline-rich protein G1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013305.2 RefSeqGene

      Range
      5001..8794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394862.1 → NP_001381791.1  basic salivary proline-rich protein 3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010176, AC244131
      Consensus CDS
      CCDS91655.1
      UniProtKB/Swiss-Prot
      F5H7C1, Q04118, Q15188, Q4VAY3, Q4VAY4, Q7M4M9, Q9UCT9
      Related
      ENSP00000442626.2, ENST00000538488.3
      Conserved Domains (1) summary
      PRK07764
      Location:50 → 264
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    2. NM_006249.5 → NP_006240.4  basic salivary proline-rich protein 3 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010176, AC244131
      UniProtKB/TrEMBL
      A0A0G2JNB4
      Conserved Domains (2) summary
      pfam10240
      Location:44 → 108
      DUF2464; Protein of unknown function (DUF2464)
      pfam15240
      Location:7 → 188
      Pro-rich; Proline-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      11265914..11269707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      460877..464670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      11135147..11138817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04118.3 GenPept UniProtKB/Swiss-Prot:Q04118

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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