DUSP14 dual specificity phosphatase 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP14provided by HGNC
Official Full Name: dual specificity phosphatase 14provided by HGNC
Primary source: HGNC:HGNC:17007
See related: Ensembl:ENSG00000276023 MIM:606618; AllianceGenome:HGNC:17007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MKP6; MKP-L
Summary: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression: Broad expression in thyroid (RPKM 9.3), skin (RPKM 8.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (37488566..37513498)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (38472550..38500180)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (35849997..35873600)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bioinformatic studies showed that these two miRNAs target PTEN and DUSP14 tumor suppressor genes. Quantitative Real-time PCR confirmed the overexpression of the miRNAs and downregulation of their targets. Luciferase assay confirmed that the miRNAs target PTEN and DUSP14.
Title: Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells.
Hepatocyte DUSP14 is required for maintaining hepatic metabolic homeostasis and for suppressing inflammation, a novel function that relies on constraining TAK1 hyperactivation
Title: Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver.
The AA genotype was associated with protection against active TB. Among disease-free individuals, T-helper type-1 related genes, IFNGR2 and STAT1 mRNA levels significantly increased as the number of A alleles of rs1051838 increased.
Title: Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis.
levels significantly decreased in failing hearts
Title: Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
these findings reveal a novel mechanism by which TRAF2 mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
Title: TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity.
findings suggest that DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation by dephosphorylating TAK1 at Thr-187
Title: The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.
DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
Title: Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
Title: Overproduction, purification and structure determination of human dual-specificity phosphatase 14.
The binding of Lipomannan to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation.
Title: Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.
Activation of ATM by radiation down-regulates phospho-ERK1/2 and its downstream signaling via increased expression of mitogen-activated protein kinase phosphatase MKP-1.
Title: Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dusp14 (e-PCR), detects polymorphism
- UniSTS:502653

D17S1362E (e-PCR)
- UniSTS:54228

G20534 (e-PCR)
- UniSTS:7916

A005V20 (e-PCR)
- UniSTS:7917

D17S1660 (e-PCR)
- UniSTS:35572

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity protein phosphatase 14

Names: MAP kinase phosphatase 6; MKP-1-like protein tyrosine phosphatase; MKP-6; mitogen-activated protein kinase phosphatase 6

NP_008957.1

EC 3.1.3.16

EC 3.1.3.48

XP_005257034.1

EC 3.1.3.16

EC 3.1.3.48

XP_011522536.1

EC 3.1.3.16

EC 3.1.3.48

XP_047291173.1

EC 3.1.3.16

EC 3.1.3.48

XP_054170826.1

EC 3.1.3.16

EC 3.1.3.48

XP_054170827.1

EC 3.1.3.16

EC 3.1.3.48

XP_054170828.1

EC 3.1.3.16

EC 3.1.3.48

XP_054170829.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185204.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185205.1

EC 3.1.3.16

EC 3.1.3.48

XP_054185206.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007026.4 → NP_008957.1 dual specificity protein phosphatase 14

See identical proteins and their annotated locations for NP_008957.1

Status: VALIDATED

Source sequence(s)

AC243585, AC243654

Consensus CDS

CCDS11320.1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36

Related

ENSP00000478595.1, ENST00000617516.5

Conserved Domains (1) summary

cd14572
Location:20 → 169

DUSP14; dual specificity protein phosphatase 14

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

37488566..37513498

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011524234.2 → XP_011522536.1 dual specificity protein phosphatase 14 isoform X1

See identical proteins and their annotated locations for XP_011522536.1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36

Conserved Domains (1) summary

cd14572
Location:20 → 169

DUSP14; dual specificity protein phosphatase 14
XM_047435217.1 → XP_047291173.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_005256977.4 → XP_005257034.1 dual specificity protein phosphatase 14 isoform X1

See identical proteins and their annotated locations for XP_005257034.1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36

Related

ENSP00000484091.1, ENST00000613659.1

Conserved Domains (1) summary

cd14572
Location:20 → 169

DUSP14; dual specificity protein phosphatase 14

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

1725025..1752665

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329231.1 → XP_054185206.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_054329230.1 → XP_054185205.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_054329229.1 → XP_054185204.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

38472550..38500180

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314854.1 → XP_054170829.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_054314853.1 → XP_054170828.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_054314851.1 → XP_054170826.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36
XM_054314852.1 → XP_054170827.1 dual specificity protein phosphatase 14 isoform X1

UniProtKB/Swiss-Prot

O95147

UniProtKB/TrEMBL

Q6FI36