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    PCGEM1 PCGEM1 prostate-specific transcript [ Homo sapiens (human) ]

    Gene ID: 64002, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PCGEM1provided by HGNC
    Official Full Name
    PCGEM1 prostate-specific transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:30145
    See related
    Ensembl:ENSG00000227418 MIM:605443; AllianceGenome:HGNC:30145
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCAT9; LINC00071; NCRNA00071
    Summary
    This gene produces a long non-coding RNA that is overexpressed in prostate cancer and may act a marker for tumor progression. This RNA may act a negative regulator of apoptosis, and may promote activity of androgen receptor and Myc. [provided by RefSeq, Dec 2017]
    Expression
    Restricted expression toward prostate (RPKM 5.3) See more
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    Genomic context

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    See PCGEM1 in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (192749845..192776899)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (193238254..193265316)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (193614571..193641625)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CAVIN2 and TMEFF2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5853 Neighboring gene DNAJB1 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:192867249-192867501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16884 Neighboring gene transmembrane protein with EGF like and two follistatin like domains 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:192976090-192976700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:192994983-192995675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:192995676-192996367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:193059605-193060180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:193372873-193373463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:193372281-193372872 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:193406886-193407706 Neighboring gene NANOG hESC enhancer GRCh37_chr2:193600042-193600633 Neighboring gene Sharpr-MPRA regulatory region 3165 Neighboring gene ribosomal protein S17 pseudogene 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:193795141-193795642 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:193795643-193796142 Neighboring gene uncharacterized LOC107985969 Neighboring gene MPRA-validated peak3996 silencer Neighboring gene SLC44A3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A review on the role of PCGEM1 lncRNA in cancer. Ghafouri-Fard S, et al. Pathol Res Pract, 2022 Dec. PMID 36403313
    2. PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Srikantan V, et al. Proc Natl Acad Sci U S A, 2000 Oct 24. PMID 11050243, Free PMC Article
    3. Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Petrovics G, et al. Oncogene, 2004 Jan 15. PMID 14724589
    4. Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue. Bialkowska-Hobrzanska H, et al. Can J Urol, 2006 Feb. PMID 16515751
    5. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. Fu X, et al. DNA Cell Biol, 2006 Mar. PMID 16569192

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
      Title: Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1.
    2. A review on the role of PCGEM1 lncRNA in cancer.
      Title: A review on the role of PCGEM1 lncRNA in cancer.
    3. LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis.
      Title: LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis.
    4. lncRNA PCGEM1 Regulates the Progress of Colorectal Cancer through Targeting miR-129-5p/SOX4.
      Title: lncRNA PCGEM1 Regulates the Progress of Colorectal Cancer through Targeting miR-129-5p/SOX4.
    5. Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1beta-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.
      Title: Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes.
    6. Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression.
      Title: Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression.
    7. PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1.
      Title: PCGEM1 promotes proliferation, migration and invasion in prostate cancer by sponging miR-506 to upregulate TRIAP1.
    8. Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.
      Title: Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.
    9. LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.
      Title: LncRNA PCGEM1 contributes to malignant behaviors of glioma by regulating miR-539-5p/CDK6 axis.
    10. LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP.
      Title: LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • PCGEM1, prostate-specific transcript (non-protein coding)
    • long intergenic non-protein coding RNA 71
    • prostate cancer associated transcript 9
    • prostate cancer gene expression marker 1
    • prostate-specific transcript 1 (non-protein coding)

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002769.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF223389
      Related
      ENST00000454040.5

    2. NR_152587.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC013401
      Related
      ENST00000606314.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      192749845..192776899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      193238254..193265316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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