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    Cphx1 cytoplasmic polyadenylated homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 105594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cphx1provided by MGI
    Official Full Name
    cytoplasmic polyadenylated homeobox 1provided by MGI
    Primary source
    MGI:MGI:2145733
    See related
    Ensembl:ENSMUSG00000095975 AllianceGenome:MGI:2145733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cphx; Cphx2; Cphx3; Eso-1; Gm2104; Gm2135; C330003B14Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; lung; and thymus. Orthologous to human CPHXL (cytoplasmic polyadenylated homeobox like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Cphx1 in Genome Data Viewer
    Location:
    14 A3; 14 15.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (25941983..25956798)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (25941559..25956374)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 254 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene double homeobox B-like 1 Neighboring gene ubiquitin specific peptidase 7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel maternally transcribed homeobox gene, Eso-1, is preferentially expressed in oocytes and regulated by cytoplasmic polyadenylation. Li H, et al. Mol Reprod Dev, 2006 Jul. PMID 16596637
    2. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic polyadenylated homeobox 1
    Names
    cytoplasmic polyadenylated homeobox 2
    cytoplasmic polyadenylated homeobox 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175342.3 → NP_780551.1  cytoplasmic polyadenylated homeobox 1

      See identical proteins and their annotated locations for NP_780551.1

      Status: VALIDATED

      Source sequence(s)
      AK049114
      Consensus CDS
      CCDS26877.1
      UniProtKB/TrEMBL
      Q8BX39
      Related
      ENSMUSP00000139237.2, ENSMUST00000184016.3
      Conserved Domains (1) summary
      cd00086
      Location:29 → 82
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      25941983..25956798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315769.1 → XP_017171258.1  cytoplasmic polyadenylated homeobox 1 isoform X1

      UniProtKB/TrEMBL
      Q8BX39
      Conserved Domains (1) summary
      cd00086
      Location:29 → 82
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_017315770.1 → XP_017171259.1  cytoplasmic polyadenylated homeobox 1 isoform X1

      UniProtKB/TrEMBL
      Q8BX39
      Conserved Domains (1) summary
      cd00086
      Location:29 → 82
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001270506.1: Suppressed sequence

      Description
      NM_001270506.1: This RefSeq was removed because it is redundant with NM_175342.3.

    2. NM_001310463.1: Suppressed sequence

      Description
      NM_001310463.1: This RefSeq was removed because it is redundant with NM_175342.3.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials