Dcaf8 DDB1 and CUL4 associated factor 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcaf8provided by RGD
Official Full Name: DDB1 and CUL4 associated factor 8provided by RGD
Primary source: RGD:1308513
See related: EnsemblRapid:ENSRNOG00000006785 AllianceGenome:RGD:1308513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr42a; RGD1308513
Summary: Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 281.3), Kidney (RPKM 236.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87141940..87199859)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84609838..84667025)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90532153..90587542)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH135139 (e-PCR)
- UniSTS:218416

RH134885 (e-PCR)
- UniSTS:218163

RH128723 (e-PCR)
- UniSTS:212031

RH134414 (e-PCR)
- UniSTS:217695

RH127477 (e-PCR)
- UniSTS:210787

RH127998 (e-PCR)
- UniSTS:210787

AU046984 (e-PCR)
- UniSTS:110955

G42043 (e-PCR)
- UniSTS:105068

RH140256 (e-PCR)
- UniSTS:222335

BF409555 (e-PCR)
- UniSTS:248988

BF399606 (e-PCR)
- UniSTS:247746

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within myotube cell development	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 8

Names: WD repeat domain 42A; WD repeat-containing protein 42A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014231.2 → NP_001014253.1 DDB1- and CUL4-associated factor 8 isoform 1

See identical proteins and their annotated locations for NP_001014253.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5U2M6

UniProtKB/TrEMBL

A0A8L2Q3J7, A6JG32

Related

ENSRNOP00000070721.1, ENSRNOT00000082469.3

Conserved Domains (3) summary

COG2319
Location:183 → 499

WD40; WD40 repeat [General function prediction only]

sd00039
Location:192 → 228

7WD40; WD40 repeat [structural motif]

cl02567
Location:183 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001429912.1 → NP_001416841.1 DDB1- and CUL4-associated factor 8 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5U2M6

UniProtKB/TrEMBL

A6JG32
NM_001429913.1 → NP_001416842.1 DDB1- and CUL4-associated factor 8 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q5U2M6

UniProtKB/TrEMBL

A6JG32
NM_001429914.1 → NP_001416843.1 DDB1- and CUL4-associated factor 8 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429915.1 → NP_001416844.1 DDB1- and CUL4-associated factor 8 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

87141940..87199859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250297.5 → XP_006250359.1 DDB1- and CUL4-associated factor 8 isoform X1

Related

ENSRNOP00000095537.2, ENSRNOT00000101398.2

Conserved Domains (3) summary

COG2319
Location:183 → 499

WD40; WD40 repeat [General function prediction only]

sd00039
Location:192 → 228

7WD40; WD40 repeat [structural motif]

cl02567
Location:183 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063272522.1 → XP_063128592.1 DDB1- and CUL4-associated factor 8 isoform X3
XM_063272520.1 → XP_063128590.1 DDB1- and CUL4-associated factor 8 isoform X2
XM_006250298.4 → XP_006250360.1 DDB1- and CUL4-associated factor 8 isoform X1

Related

ENSRNOP00000008944.6, ENSRNOT00000008944.9

Conserved Domains (3) summary

COG2319
Location:183 → 499

WD40; WD40 repeat [General function prediction only]

sd00039
Location:192 → 228

7WD40; WD40 repeat [structural motif]

cl02567
Location:183 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...